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Experimental Animal Studies with Griseofulvin

Experimental Animal Studies with Griseofulvin Abstract Controlled studies by Gentles1 using guinea pigs infected with Microsporum canis which he subsequently treated with griseofulvin, was the first successful venture in the systemic management of superficial mycoses. He reported that the beneficial effect of griseofulvin treatment was evident after four days of treatment and after eight days the infection had been almost completely eradicated. He also stated that guinea pigs with experimentally induced Trichophyton mentagrophytes infections responded in a similar manner. In a later report,2 he postulated that griseofulvin was deposited in the hair follicles and became incorporated into the newly formed keratin of the hair shafts as well as the keratin layer of the epidermis. Robinson et al.,3 utilizing the spectrophotometric assay method of Ashton and Brown,4 performed in vitro and in vivo studies to determine the concentration of griseofulvin in the blood and urine; concentrations were very low when considered in relation References 1. Gentles, J. C.: Experimental Ringworm in Guinea Pigs: Oral Treatment with Griseofulvin , Nature, London 182:476, 1958.Crossref 2. Gentles, J. C.; Barnes, M. J., and Fantes, K. H.: Presence of Griseofulvin in Hair of Guinea Pigs After Oral Administration , Nature, London 183:256, 1959.Crossref 3. Robinson, H. M., Jr.; Robinson, R. C. V.; Bereston, E. S.; Manchey, L. L., and Bell, F. K.: Griseofulvin, Clinical and Experimental Studies , A.M.A. Arch. Dermat. , to be published. 4. Ashton, G. C., and Brown, A. P.: Determination of Griseofulvin in Fermentation Samples: I. Spectrophotometric Assay , Analyst 81:220-224, 1956.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1960.03730050065012
Publisher site
See Article on Publisher Site

Abstract

Abstract Controlled studies by Gentles1 using guinea pigs infected with Microsporum canis which he subsequently treated with griseofulvin, was the first successful venture in the systemic management of superficial mycoses. He reported that the beneficial effect of griseofulvin treatment was evident after four days of treatment and after eight days the infection had been almost completely eradicated. He also stated that guinea pigs with experimentally induced Trichophyton mentagrophytes infections responded in a similar manner. In a later report,2 he postulated that griseofulvin was deposited in the hair follicles and became incorporated into the newly formed keratin of the hair shafts as well as the keratin layer of the epidermis. Robinson et al.,3 utilizing the spectrophotometric assay method of Ashton and Brown,4 performed in vitro and in vivo studies to determine the concentration of griseofulvin in the blood and urine; concentrations were very low when considered in relation References 1. Gentles, J. C.: Experimental Ringworm in Guinea Pigs: Oral Treatment with Griseofulvin , Nature, London 182:476, 1958.Crossref 2. Gentles, J. C.; Barnes, M. J., and Fantes, K. H.: Presence of Griseofulvin in Hair of Guinea Pigs After Oral Administration , Nature, London 183:256, 1959.Crossref 3. Robinson, H. M., Jr.; Robinson, R. C. V.; Bereston, E. S.; Manchey, L. L., and Bell, F. K.: Griseofulvin, Clinical and Experimental Studies , A.M.A. Arch. Dermat. , to be published. 4. Ashton, G. C., and Brown, A. P.: Determination of Griseofulvin in Fermentation Samples: I. Spectrophotometric Assay , Analyst 81:220-224, 1956.Crossref

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: May 1, 1960

References