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EXPERIMENTAL ANEMIA PRODUCED BY CLOSTRIDIUM WELCHII: CHEMICAL ANALYSIS OF THE BLOOD

EXPERIMENTAL ANEMIA PRODUCED BY CLOSTRIDIUM WELCHII: CHEMICAL ANALYSIS OF THE BLOOD Abstract In a preceding paper,1 the general problem of the significance of the anaerobic intestinal bacteria in relation to human disease was presented, and experimental studies of these microbes, more especially of those belonging to the species Clostridium welchii, were described. A toxic anemia of severe grade was induced by inoculation of these organisms. A comparison of the results of chemical analyses of the blood of these experimental animals with similar results on control normal animals, and especially with analogous results obtained in clinical diseases of man, is our purpose in the present communication. The difficulty of applying conceptions derived from animal experimentation at once in clinical medicine is keenly appreciated. Nevertheless, living things have much in common, and the results of animal experimentation have already proved of value in the study of anemia. In the present study, attention has been devoted especially to that group of experimental animals in which References 1. Patterson, Marjorie B., and Kast, Ludwig: Toxic Anemia Produced by Clostridium Welchii , Arch. Path. 5 ( (March) ) 1928. 2. Bull, Carroll G., and Pritchell, Ida W.: J. Exper. Med. 26:867, 1917.Crossref 3. Kahn, M. C., and Torrey, J. C.: Proc. Soc. Exper. Biol. & Med. 22:8, 1925. 4. Newcomer, H. S.: J. Biol. Chem. 37:465, 1919. 5. Myers, Victor C.: Practical Chemical Analysis of Blood , St. Louis, C. V. Mosby Company, 1924. 6. Lindsay, J. W.; Rice, C. E., and Selinger, M. A.: J. Lab. & Clin. Med. 11:737, 1926. 7. Folin, O., and Wu, H.: J. Biol. Chem. 41:367, 1920. 8. Baumann, E. J., and Holly, O. M.: J. Biol. Chem. 55:457, 1923. 9. Bernheim, A. R.: Icterus Index (A Quantitative Estimation of Bilirubinemia) , J. A. M. A. 82:291 ( (Jan. 26) ) 1924. 10. Nuzum, F. R.; Osborne, M., and Sansum, W. D.: Experimental Production of Hypertension , Arch. Int. Med. 35:492 ( (April) ) 1925. 11. Horvath, A. A.: J. Biol. Chem. 68:343, 1926. 12. Myers, V. C.: Physiol. Rev. 4:274, 1924. 13. Kast, L., and Wardell, E. L.: Urea in Human Blood , Arch. Int. Med. 22:581 ( (Nov.) ) 1918. 14. bushnell, L. D., and Bangs, E. F.: J. Infect. Dis. 39:291, 1926. 15. Folin, O., and Berglund, H.: J. Biol. Chem. 51:418, 1922. 16. Folin, O.: Physiol. Rev. 2:460, 1922. 17. Kahn, M., and Barsky, J.: Chemistry of Pernicious Anemia , Arch. Int. Med. 23:334 ( (March) ) 1919. 18. Gettler, A. O., and Lindeman, E.: Blood Chemistry of Pernicious Anemia , Arch. Int. Med. 26:453 ( (Oct.) ) 1920. 19. Folin, O.: J. Biol. Chem. 51:374, 1922. 20. Greene, C. H.; Sandiford, K., and Ross, H.: J. Biol. Chem. 58:845, 1923-1924. 21. Berglund, H.: Nitrogen Retention in Chronic Interstitial Nephritis , J. A. M. A. 79:1375 ( (Oct. 21) ) 1922. 22. Zeckwer, I. T., and Goodell. H.: J. Exper. Med. 42:43, 1925. 23. Mahler, A.: J. Biol. Chem. 69:653, 1926. 24. Chauffard, quoted by Campbell, J. M. H.: Quart. J. Med. 18:393, 1924-1925. 25. Horiuchi, Y.: J. Biol. Chem. 44:347, 1920. 26. Elman, R., and McMaster, P. D.: J. Exper. Med. 41:503, 1925.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

EXPERIMENTAL ANEMIA PRODUCED BY CLOSTRIDIUM WELCHII: CHEMICAL ANALYSIS OF THE BLOOD

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Publisher
American Medical Association
Copyright
Copyright © 1928 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1928.00130150077005
Publisher site
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Abstract

Abstract In a preceding paper,1 the general problem of the significance of the anaerobic intestinal bacteria in relation to human disease was presented, and experimental studies of these microbes, more especially of those belonging to the species Clostridium welchii, were described. A toxic anemia of severe grade was induced by inoculation of these organisms. A comparison of the results of chemical analyses of the blood of these experimental animals with similar results on control normal animals, and especially with analogous results obtained in clinical diseases of man, is our purpose in the present communication. The difficulty of applying conceptions derived from animal experimentation at once in clinical medicine is keenly appreciated. Nevertheless, living things have much in common, and the results of animal experimentation have already proved of value in the study of anemia. In the present study, attention has been devoted especially to that group of experimental animals in which References 1. Patterson, Marjorie B., and Kast, Ludwig: Toxic Anemia Produced by Clostridium Welchii , Arch. Path. 5 ( (March) ) 1928. 2. Bull, Carroll G., and Pritchell, Ida W.: J. Exper. Med. 26:867, 1917.Crossref 3. Kahn, M. C., and Torrey, J. C.: Proc. Soc. Exper. Biol. & Med. 22:8, 1925. 4. Newcomer, H. S.: J. Biol. Chem. 37:465, 1919. 5. Myers, Victor C.: Practical Chemical Analysis of Blood , St. Louis, C. V. Mosby Company, 1924. 6. Lindsay, J. W.; Rice, C. E., and Selinger, M. A.: J. Lab. & Clin. Med. 11:737, 1926. 7. Folin, O., and Wu, H.: J. Biol. Chem. 41:367, 1920. 8. Baumann, E. J., and Holly, O. M.: J. Biol. Chem. 55:457, 1923. 9. Bernheim, A. R.: Icterus Index (A Quantitative Estimation of Bilirubinemia) , J. A. M. A. 82:291 ( (Jan. 26) ) 1924. 10. Nuzum, F. R.; Osborne, M., and Sansum, W. D.: Experimental Production of Hypertension , Arch. Int. Med. 35:492 ( (April) ) 1925. 11. Horvath, A. A.: J. Biol. Chem. 68:343, 1926. 12. Myers, V. C.: Physiol. Rev. 4:274, 1924. 13. Kast, L., and Wardell, E. L.: Urea in Human Blood , Arch. Int. Med. 22:581 ( (Nov.) ) 1918. 14. bushnell, L. D., and Bangs, E. F.: J. Infect. Dis. 39:291, 1926. 15. Folin, O., and Berglund, H.: J. Biol. Chem. 51:418, 1922. 16. Folin, O.: Physiol. Rev. 2:460, 1922. 17. Kahn, M., and Barsky, J.: Chemistry of Pernicious Anemia , Arch. Int. Med. 23:334 ( (March) ) 1919. 18. Gettler, A. O., and Lindeman, E.: Blood Chemistry of Pernicious Anemia , Arch. Int. Med. 26:453 ( (Oct.) ) 1920. 19. Folin, O.: J. Biol. Chem. 51:374, 1922. 20. Greene, C. H.; Sandiford, K., and Ross, H.: J. Biol. Chem. 58:845, 1923-1924. 21. Berglund, H.: Nitrogen Retention in Chronic Interstitial Nephritis , J. A. M. A. 79:1375 ( (Oct. 21) ) 1922. 22. Zeckwer, I. T., and Goodell. H.: J. Exper. Med. 42:43, 1925. 23. Mahler, A.: J. Biol. Chem. 69:653, 1926. 24. Chauffard, quoted by Campbell, J. M. H.: Quart. J. Med. 18:393, 1924-1925. 25. Horiuchi, Y.: J. Biol. Chem. 44:347, 1920. 26. Elman, R., and McMaster, P. D.: J. Exper. Med. 41:503, 1925.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Mar 1, 1928

References