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EXPERIMENTAL AND CLINICAL OBSERVATIONS WITH HISTAMINASE

EXPERIMENTAL AND CLINICAL OBSERVATIONS WITH HISTAMINASE Abstract About ten years ago Best and McHenry discovered that certain organs of the dog, particularly the gastrointestinal tract and the kidney, contained a substance capable of inactivating histamine.1 To this material they attributed the characteristics of an enzyme, and they suggested the name histaminase. They found that it could be prepared in the form of a stable powder so that chemical and physical properties were more readily studied. These investigators found that certain optimum conditions were essential for the maximum activity of histaminase, namely, incubation with the substrate for twenty-four hours at 37 C. and a hydrogen ion concentration of 7.2. Under these conditions detectable destruction of histamine occurred only after an incubation period of four hours. Best and McHenry also defined a convenient unit of histaminase as the amount necessary to destroy 1 mg. of histamine under the aforementioned optimum conditions. Using a commercial preparation,2 Felix3 was References 1. Best, C. H.: The Disappearance of Histamine from Autolyzing Lung Tissue , J. Physiol. 67:256 ( (June) ) 1929. 2. Best, C. H., and McHenry, E. W.: The Inactivation of Histamine , J. Physiol. 70:349 ( (Dec.) ) 1930. 3. The preparation used was torantil (or T. 360), manufactured by the Winthrop Chemical Co., Inc., New York, and supplied in ampules of 1 and 2 units as well as in tablets of 5 units, a unit being as defined in the text. 4. Felix, I.: Experimental and Clinical Investigations of the Action of Histaminase Contained in Extracts of the Mucous Membrane of the Intestines on Histamine , Acta med. Scandinav. 95:1, 1938.Crossref 5. Biguria, F., and Canzanelli, A.: The Effect of Continued Oral Administration of Histaminase and Pancreatin on Gastric Secretion , Am. J. Physiol. 110: 243 ( (Nov.) ) 1934. 6. Atkinson, A. J., and Ivy, A. C.: The Action of Histaminase on the Gastric Secretory Response to Histamine and to a Meal , Am. J. Physiol. 107:168 ( (Jan.) ) 1934. 7. Bosse, M. D.: The Effect of Histaminase on the Shwartzman Phenomenon , J. Lab. & Clin. Med. , to be published. 8. MacGregor, R. G., and Peat, S.: The Histamine-Histaminase System in the Isolated Perfused Kidney-Lung Preparation , J. Physiol. 77:310 ( (Feb.) ) 1933. 9. Suzuki, R.: Studien über den experimentellen Nachweiss der das Histamine im lebendigen Körper vernichtenden Histaminasenwirkung , Taiwan Igakkai Zassi 47:68 ( (Jan.) ) 1937. 10. Takebayashi, R.: Die Bedeutung des Histamins in der experimentellen Pathologie und Chirurgie , Deutsche Ztschr. f. Chir. 249:256, 1937.Crossref 11. Ungar, G., and Bolgert, M.: Essais de prevention des lésions pulmonaires mortelles consécutives à l'inhalation de vapeurs irritantes par l'acide ascorbique et par l'histaminase , Compt. rend. Soc. de biol. 129:1107, 1938. 12. Karady, S., and Browne, J. S. L.: Effect of Histaminase Treatment on Histamine and Anaphylactic Shock in Guinea Pigs , J. Immunol. 37:463 ( (Nov.) ) 1939. 13. Knoll, A. F.: The Ineffectiveness of Pretreatment with Histaminase on Anaphylactic Shock in Guinea Pigs, to be published. 14. The histaminase employed throughout this study was that prepared by the Winthrop Chemical Co., Inc., of New York, and sold under the name torantil. Some of the material was donated by this concern. 15. Rostenberg, A., and Sulzberger, M. B., in discussion on Laymon and Cummings.18b 16. Dale, H. H.: Croonian Lectures on Some Chemical Factors in the Control of the Circulation , Lancet 1:1285 ( (June 22) ) 1929. 17. Albus, G.: Ueber die Aktivität der Histaminase und der Cholinesterase beim latenten Allergiker , Klin. Wchnschr. 18:858 ( (June 17) ) 1939.Crossref 18. Goodson, W. H., Jr.: Physical Allergy , Proc. Staff Meet., Mayo Clin. 13: 500 ( (Aug. 10) ) 1938. 19. Forman, J.: The Use of Histaminase in the Treatment of Various Allergic Manifestations , Ohio State M. J. 36:56 ( (Jan.) ) 1940. 20. Laymon, C. W., and Cummings, H.: Histaminase in the Treatment of Urticaria, and Atopic Dermatitis: Preliminary Report , J. Invest. Dermat. 2:301 ( (Dec.) ) 1939.Crossref 21. Miller, H., and Piness, G.: Histaminase in Treatment of Allergy , J. A. M. A 114:1742 ( (May 4) ) 1940. 22. Ertl, E.: Zur endonasalen Heufieberbehandlung , Monatschr. f. Ohrenh. 71:122 ( (Jan.) ) 1937. 23. Ertl, E.: Zur Therapie des Heuschnupfens , Wien. klin. Wchnschr. 52:643 ( (July 7) ) 1939. 24. Matras, A., in discussion on Urbach.18q 25. Rothman, S., in discussion on Laymon and Cummings.18b 26. Foshay, L., and Hagebusch, O. E.: Histaminase in Treatment of Serum Sickness , J. A. M. A. 112:2398 ( (June 10) ) 1939;Crossref 27. Serum Sickness: Effective Treatment and Probably Prophylaxis by Means of Histaminase , Foshay J. A. M. A. 112:1102 ( (March 18) ) 1939.Crossref 28. von Hartmann, M.: Ueber die Behand-lung der Akne vulgaris mit Torantil , Dermat. Wchnschr. 106:693 ( (June 18) ) 1938. 29. Doucas, C.: Zwei Fälle von polymorpher Akne vulgaris behandelt mit Torantil , Dermat. Wchnschr. 108:713 ( (June 24) ) 1939. 30. Adelsberger, L.: Darmextrakte bei allergischen Krankheiten , Fortschr. d. Therap. 13:568 ( (Oct.) ) 1937. 31. Roth, G. M., and Horton, B. T.: Hypersensitiveness to Cold: Treatment with Histamine and Histaminase , Proc. Staff Meet., Mayo Clin. 14:353 ( (June 7) ) 1938. 32. Baker, T. W.: Histaminase in Treatment of Cold Allergy , J. A. M. A. 114:1059 ( (March 23) ) 1940. 33. Vaisberg, M.: Histaminase in Treatment of Physical (Heat) Allergy and Some Other Conditions , New York State J. Med. 39:2199 ( (Dec. 1) ) 1939. 34. Doucas, C.: Lupus erythematodes behandelt mit Torantil , Dermat. Wchnschr. 109:812 ( (July 8) ) 1939. 35. Urbach, E.: Intestinal-toxisch bedingter Charakter einer chronisch rezidivierender Purpura durch Torantil festgestellt , Zentralbl. f. Haut- u. Geschlechtskr. 54:70, 1936. 36. Prickman, L. E., in discussion on Foshay and Hagebusch.18l 37. Eustis, A.: The Relation of Histaminase to Toxemia and Asthma , New Orleans M. & S. J. 92:350 ( (Jan.) ) 1940. 38. Roth, G. M., and Rynearson, E. H.: The Use of Histamine and Histaminase in the Treatment of Allergic Reactions to Insulin , Proc. Staff Meet., Mayo Clin. 14:353 ( (June 7) ) 1938. 39. Abel, O., Jr.; Siebert, W. J., and Earp, R.: Fibrositis , J. Missouri M. A. 36:435 ( (Nov.) ) 1939. 40. Moldenschardt, H.: Torantil, ein aus Darmschleimhaut gewonnes Präparat , Med. Klin. 32:153 ( (Jan. 31) ) 1936. 41. Ercklentz, W., and Ercklentz, B. W.: Ueber Anti-Histaminwirkung im Organismus durch "Torantil," München. med. Wchnschr. 83:17 ( (Jan. 3) ) 1936. 42. Rackemann, F. M.: Allergic Diseases with Special Reference to Histamine and Acetylcholine , New England J. Med. 222:674 ( (April 18) ) 1940. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

EXPERIMENTAL AND CLINICAL OBSERVATIONS WITH HISTAMINASE

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Publisher
American Medical Association
Copyright
Copyright © 1940 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1940.01490170146014
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Abstract

Abstract About ten years ago Best and McHenry discovered that certain organs of the dog, particularly the gastrointestinal tract and the kidney, contained a substance capable of inactivating histamine.1 To this material they attributed the characteristics of an enzyme, and they suggested the name histaminase. They found that it could be prepared in the form of a stable powder so that chemical and physical properties were more readily studied. These investigators found that certain optimum conditions were essential for the maximum activity of histaminase, namely, incubation with the substrate for twenty-four hours at 37 C. and a hydrogen ion concentration of 7.2. Under these conditions detectable destruction of histamine occurred only after an incubation period of four hours. Best and McHenry also defined a convenient unit of histaminase as the amount necessary to destroy 1 mg. of histamine under the aforementioned optimum conditions. Using a commercial preparation,2 Felix3 was References 1. Best, C. H.: The Disappearance of Histamine from Autolyzing Lung Tissue , J. Physiol. 67:256 ( (June) ) 1929. 2. Best, C. H., and McHenry, E. W.: The Inactivation of Histamine , J. Physiol. 70:349 ( (Dec.) ) 1930. 3. The preparation used was torantil (or T. 360), manufactured by the Winthrop Chemical Co., Inc., New York, and supplied in ampules of 1 and 2 units as well as in tablets of 5 units, a unit being as defined in the text. 4. Felix, I.: Experimental and Clinical Investigations of the Action of Histaminase Contained in Extracts of the Mucous Membrane of the Intestines on Histamine , Acta med. Scandinav. 95:1, 1938.Crossref 5. Biguria, F., and Canzanelli, A.: The Effect of Continued Oral Administration of Histaminase and Pancreatin on Gastric Secretion , Am. J. Physiol. 110: 243 ( (Nov.) ) 1934. 6. Atkinson, A. J., and Ivy, A. C.: The Action of Histaminase on the Gastric Secretory Response to Histamine and to a Meal , Am. J. Physiol. 107:168 ( (Jan.) ) 1934. 7. Bosse, M. D.: The Effect of Histaminase on the Shwartzman Phenomenon , J. Lab. & Clin. Med. , to be published. 8. MacGregor, R. G., and Peat, S.: The Histamine-Histaminase System in the Isolated Perfused Kidney-Lung Preparation , J. Physiol. 77:310 ( (Feb.) ) 1933. 9. Suzuki, R.: Studien über den experimentellen Nachweiss der das Histamine im lebendigen Körper vernichtenden Histaminasenwirkung , Taiwan Igakkai Zassi 47:68 ( (Jan.) ) 1937. 10. Takebayashi, R.: Die Bedeutung des Histamins in der experimentellen Pathologie und Chirurgie , Deutsche Ztschr. f. Chir. 249:256, 1937.Crossref 11. Ungar, G., and Bolgert, M.: Essais de prevention des lésions pulmonaires mortelles consécutives à l'inhalation de vapeurs irritantes par l'acide ascorbique et par l'histaminase , Compt. rend. Soc. de biol. 129:1107, 1938. 12. Karady, S., and Browne, J. S. L.: Effect of Histaminase Treatment on Histamine and Anaphylactic Shock in Guinea Pigs , J. Immunol. 37:463 ( (Nov.) ) 1939. 13. Knoll, A. F.: The Ineffectiveness of Pretreatment with Histaminase on Anaphylactic Shock in Guinea Pigs, to be published. 14. The histaminase employed throughout this study was that prepared by the Winthrop Chemical Co., Inc., of New York, and sold under the name torantil. Some of the material was donated by this concern. 15. Rostenberg, A., and Sulzberger, M. B., in discussion on Laymon and Cummings.18b 16. Dale, H. H.: Croonian Lectures on Some Chemical Factors in the Control of the Circulation , Lancet 1:1285 ( (June 22) ) 1929. 17. Albus, G.: Ueber die Aktivität der Histaminase und der Cholinesterase beim latenten Allergiker , Klin. Wchnschr. 18:858 ( (June 17) ) 1939.Crossref 18. Goodson, W. H., Jr.: Physical Allergy , Proc. Staff Meet., Mayo Clin. 13: 500 ( (Aug. 10) ) 1938. 19. Forman, J.: The Use of Histaminase in the Treatment of Various Allergic Manifestations , Ohio State M. J. 36:56 ( (Jan.) ) 1940. 20. Laymon, C. W., and Cummings, H.: Histaminase in the Treatment of Urticaria, and Atopic Dermatitis: Preliminary Report , J. Invest. Dermat. 2:301 ( (Dec.) ) 1939.Crossref 21. Miller, H., and Piness, G.: Histaminase in Treatment of Allergy , J. A. M. A 114:1742 ( (May 4) ) 1940. 22. Ertl, E.: Zur endonasalen Heufieberbehandlung , Monatschr. f. Ohrenh. 71:122 ( (Jan.) ) 1937. 23. Ertl, E.: Zur Therapie des Heuschnupfens , Wien. klin. Wchnschr. 52:643 ( (July 7) ) 1939. 24. Matras, A., in discussion on Urbach.18q 25. Rothman, S., in discussion on Laymon and Cummings.18b 26. Foshay, L., and Hagebusch, O. E.: Histaminase in Treatment of Serum Sickness , J. A. M. A. 112:2398 ( (June 10) ) 1939;Crossref 27. Serum Sickness: Effective Treatment and Probably Prophylaxis by Means of Histaminase , Foshay J. A. M. A. 112:1102 ( (March 18) ) 1939.Crossref 28. von Hartmann, M.: Ueber die Behand-lung der Akne vulgaris mit Torantil , Dermat. Wchnschr. 106:693 ( (June 18) ) 1938. 29. Doucas, C.: Zwei Fälle von polymorpher Akne vulgaris behandelt mit Torantil , Dermat. Wchnschr. 108:713 ( (June 24) ) 1939. 30. Adelsberger, L.: Darmextrakte bei allergischen Krankheiten , Fortschr. d. Therap. 13:568 ( (Oct.) ) 1937. 31. Roth, G. M., and Horton, B. T.: Hypersensitiveness to Cold: Treatment with Histamine and Histaminase , Proc. Staff Meet., Mayo Clin. 14:353 ( (June 7) ) 1938. 32. Baker, T. W.: Histaminase in Treatment of Cold Allergy , J. A. M. A. 114:1059 ( (March 23) ) 1940. 33. Vaisberg, M.: Histaminase in Treatment of Physical (Heat) Allergy and Some Other Conditions , New York State J. Med. 39:2199 ( (Dec. 1) ) 1939. 34. Doucas, C.: Lupus erythematodes behandelt mit Torantil , Dermat. Wchnschr. 109:812 ( (July 8) ) 1939. 35. Urbach, E.: Intestinal-toxisch bedingter Charakter einer chronisch rezidivierender Purpura durch Torantil festgestellt , Zentralbl. f. Haut- u. Geschlechtskr. 54:70, 1936. 36. Prickman, L. E., in discussion on Foshay and Hagebusch.18l 37. Eustis, A.: The Relation of Histaminase to Toxemia and Asthma , New Orleans M. & S. J. 92:350 ( (Jan.) ) 1940. 38. Roth, G. M., and Rynearson, E. H.: The Use of Histamine and Histaminase in the Treatment of Allergic Reactions to Insulin , Proc. Staff Meet., Mayo Clin. 14:353 ( (June 7) ) 1938. 39. Abel, O., Jr.; Siebert, W. J., and Earp, R.: Fibrositis , J. Missouri M. A. 36:435 ( (Nov.) ) 1939. 40. Moldenschardt, H.: Torantil, ein aus Darmschleimhaut gewonnes Präparat , Med. Klin. 32:153 ( (Jan. 31) ) 1936. 41. Ercklentz, W., and Ercklentz, B. W.: Ueber Anti-Histaminwirkung im Organismus durch "Torantil," München. med. Wchnschr. 83:17 ( (Jan. 3) ) 1936. 42. Rackemann, F. M.: Allergic Diseases with Special Reference to Histamine and Acetylcholine , New England J. Med. 222:674 ( (April 18) ) 1940.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Nov 1, 1940

References