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EXPERIMENTAL ACNE VARIOLIFORMIS

EXPERIMENTAL ACNE VARIOLIFORMIS Abstract The acne varioliformis referred to in this study is that of the Hebra, i. e., the more widespread, deep-seated, indurative form followed by varioliform scars. Case 1 was of the extreme type, both as to distribution and character of lesion. Case 2 was more limited. However, common to both cases were the indurative, woody edema, hemorrhagic deep necroses and correspondingly deep varioliform scarring that are not seen in the acne necrotica of Boeck. Our experiments were confined to reproduction of the lesions, but nothing was done to ascertain their distribution. The lesions were produced both in guinea-pigs and in the patient himself with the streptococcus associated with the staphylococcus. I believe that the streptococcus is to be looked on as the agent that caused the distinctive features of the lesion in the two cases reported. REPORT OF CASES Case 1.— Nicholas F., a youth, aged 18, white, of Italian parentage, References 1. In the light of serologic tests, this was claimed as Type 1 of the hemolytic group of streptococci (Bergey: Manual of Determinative Bacteriology 1923. pp. 47 and 48). 2. A stock culture of Streptococcus pyogenes-hemolyticus, that had been preserved in culture for a number of months by Dr. Julianelle, and Staphylococcus pyogenes aureus hemolyticus freshly isolated from an extensive abscess of the leg were used. A guinea-pig injected with 1 c.c. of each of the two preceding cultures died in forty-eight hours. 3. Barthélemy, M.: De l'acnitis , Ann. de dermat. et. syph. 2:1, 1891. 4. Gardiner, F.: Acne necrotica , Inter. Clin. , Philadelphia, 27:104, 1917. 5. Fordyce, J. A.: A Contribution to the Pathology of Acne Varioliformis Hebrae , J. Cutan. Dis. 12:152, 1894. 6. Fordyce, J. A.: A Contribution to the Pathology of the Acne Varioliformis Hebrae , J. Cutan. Dis. 9:128, 1891. 7. Touton, quoted from Fordyce: Verhandl. d. deutsch. dermat. gesellsch., Zweiter und Dritter Congress. 8. Boeck, C.: Ueber Acne frontalis necrotica , Arch. f. Dermat. u. Syph. 21:37, 1889.Crossref 9. Pollitzer, S.: Hydradenitis destruens suppurativa , J. Cutan. Dis. 10:9, 1892. 10. Schamberg, J. F.: A Study of Acnitis with the Report of an Extensive Case , J. Cutan. Dis. 27:14, 1909. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

EXPERIMENTAL ACNE VARIOLIFORMIS

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Publisher
American Medical Association
Copyright
Copyright © 1924 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1924.02360300032002
Publisher site
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Abstract

Abstract The acne varioliformis referred to in this study is that of the Hebra, i. e., the more widespread, deep-seated, indurative form followed by varioliform scars. Case 1 was of the extreme type, both as to distribution and character of lesion. Case 2 was more limited. However, common to both cases were the indurative, woody edema, hemorrhagic deep necroses and correspondingly deep varioliform scarring that are not seen in the acne necrotica of Boeck. Our experiments were confined to reproduction of the lesions, but nothing was done to ascertain their distribution. The lesions were produced both in guinea-pigs and in the patient himself with the streptococcus associated with the staphylococcus. I believe that the streptococcus is to be looked on as the agent that caused the distinctive features of the lesion in the two cases reported. REPORT OF CASES Case 1.— Nicholas F., a youth, aged 18, white, of Italian parentage, References 1. In the light of serologic tests, this was claimed as Type 1 of the hemolytic group of streptococci (Bergey: Manual of Determinative Bacteriology 1923. pp. 47 and 48). 2. A stock culture of Streptococcus pyogenes-hemolyticus, that had been preserved in culture for a number of months by Dr. Julianelle, and Staphylococcus pyogenes aureus hemolyticus freshly isolated from an extensive abscess of the leg were used. A guinea-pig injected with 1 c.c. of each of the two preceding cultures died in forty-eight hours. 3. Barthélemy, M.: De l'acnitis , Ann. de dermat. et. syph. 2:1, 1891. 4. Gardiner, F.: Acne necrotica , Inter. Clin. , Philadelphia, 27:104, 1917. 5. Fordyce, J. A.: A Contribution to the Pathology of Acne Varioliformis Hebrae , J. Cutan. Dis. 12:152, 1894. 6. Fordyce, J. A.: A Contribution to the Pathology of the Acne Varioliformis Hebrae , J. Cutan. Dis. 9:128, 1891. 7. Touton, quoted from Fordyce: Verhandl. d. deutsch. dermat. gesellsch., Zweiter und Dritter Congress. 8. Boeck, C.: Ueber Acne frontalis necrotica , Arch. f. Dermat. u. Syph. 21:37, 1889.Crossref 9. Pollitzer, S.: Hydradenitis destruens suppurativa , J. Cutan. Dis. 10:9, 1892. 10. Schamberg, J. F.: A Study of Acnitis with the Report of an Extensive Case , J. Cutan. Dis. 27:14, 1909.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Dec 1, 1924

References