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Experiences with Regional Chemotherapy: Perfusion and Intra-Arterial Infusion

Experiences with Regional Chemotherapy: Perfusion and Intra-Arterial Infusion Abstract During the past 4 years, regional chemotherapy has been employed in the M. D. Anderson Hospital primarily as a medium of research in cancer, and secondarily for therapeutic purposes. At present, the 2 methods of administration consist of (1) perfusion with the use of the heart-lung machine, as suggested by Klopp5,6 and developed by Creech,2,3 and (2) continuous intra-arterial infusion, based upon the original work of Klopp5,6 and Bierman1 and their co-workers, and developed by Sullivan.14 As of Dec. 1, 1961, 265 perfusions had been performed for 209 patients, and 54 infusions for 48 patients. In the conviction that major "breakthroughs" in cancer research can best be achieved by cooperation between clinicians and investigators in the basic sciences, our approach has been a multidisciplinal one, in which surgeons, radiotherapists, pathologists, biochemists, biologists, and physicists have worked together. Herein will be presented some of the investigative References 1. Bierman, H. R.; Byron, R. L., Jr.; Miller, E. R., and Shimkin, M. B.: The Effects of Intra-Arterial Administration of Nitrogen Mustard, Fifth International Congress of Cancer , 1950, Paris, Hermann, p. 186 2. abstracted in Amer. J. Med. 8:535, 1950. 3. Creech, O., Jr.; Krementz, E. T.; Ryan, R. F., and Winblad, J. N.: Chemotherapy of Cancer: Regional Perfusion Utilizing an Extra-Corporeal Circuit , Ann. Surg. 148:616, 1958.Crossref 4. Creech, O., Jr.; Ryan, R. F., and Krementz, E. T.: Treatment of Melanoma by Isolation-Perfusion Technique , J.A.M.A. 169:339, 1959.Crossref 5. Klatt, O.; Griffin, A. C., and Stehlin, J. S., Jr.: Method for Determination of Phenylalanine Mustard and Related Alkylating Agents in Blood , Proc. Soc. Exp. Biol. Med. 104:629, 1960.Crossref 6. Klopp, C. T.; Alford, T. C.; Bateman, J.; Berry, G. N., and Winship, T.: Fractionated Intra-Arterial Cancer Chemotherapy with Methyl-Bis-Amine Hydrochloride: A Preliminary Report , Ann. Surg. 132:811, 1950.Crossref 7. Klopp, C. T.; Bateman, J.; Berry, G. N.; Alford, T. C., and Winship, T.: Fractionated Regional Cancer Chemotherapy , Cancer Res. 10:229, 1950. 8. Milner, A. N., and Stehlin, J. S., Jr.: Urinary Excretion Patterns of Patients Following Administration of Alkylating Agents by Regional Perfusion Technic , Proc. Amer. Ass. Cancer Res. (Abstr.) 3:134, 1960. 9. Milner, A. N., and Stehlin, J. S., Jr.: Studies of Carbohydrate Metabolism of Isolated Areas During Regional Perfusion for Cancer , Proc. Amer. Ass. Cancer Res. (Abstr.) 3:252, 1961. 10. Rose, G. G., and Stehlin, J. S., Jr.: The Golgi Complex and Melanin Elaboration of Human Melanomes in Tissue Culture, Cancer Res., to be published. 11. Stehlin, J. S., Jr.; Clark, R. L., Jr., and Dewey, W. C.: Continuous Monitoring of Leakage During Regional Perfusion , A.M.A. Arch. Surg. 83:943, 1961.Crossref 12. Stehlin, J. S., Jr.; Clark, R. L., Jr.; Smith, J. L., Jr., and White, E. C.: Malignant Melanoma of the Extremities: Experiences with Conventional Therapy, A New Surgical and Chemotherapeutic Approach with Regional Perfusion , Cancer 13:55, 1960.Crossref 13. Stehlin, J. S., Jr.; Clark, R. L., Jr.; White, E. C.; Healey, J. E., Jr; Dewey, W. C., and Beerstecher, S: The Leakage Factor in Regional Perfusion with Chemotherapeutic Agents , A.M.A. Arch. Surg. 80:934, 1960.Crossref 14. Stehlin, J. S., Jr.; Clark, R. L., Jr.; White, E. C.; Smith, J. L., Jr.; Griffin, A. C.; Jesse, R. H., Jr., and Healey, J. E., Jr.: Regional Chemotherapy for Cancer: Experiences with 116 Perfusions , Ann. Surg. 151:605, 1960.Crossref 15. Sullivan, R. D.; Miller, E., and Sikes, M. P.: Antimetabolite-Metabolite Combination Cancer Chemotherapy , Cancer 12:1248, 1959.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Experiences with Regional Chemotherapy: Perfusion and Intra-Arterial Infusion

Archives of Surgery , Volume 85 (1) – Jul 1, 1962

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Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1962.01310010088013
Publisher site
See Article on Publisher Site

Abstract

Abstract During the past 4 years, regional chemotherapy has been employed in the M. D. Anderson Hospital primarily as a medium of research in cancer, and secondarily for therapeutic purposes. At present, the 2 methods of administration consist of (1) perfusion with the use of the heart-lung machine, as suggested by Klopp5,6 and developed by Creech,2,3 and (2) continuous intra-arterial infusion, based upon the original work of Klopp5,6 and Bierman1 and their co-workers, and developed by Sullivan.14 As of Dec. 1, 1961, 265 perfusions had been performed for 209 patients, and 54 infusions for 48 patients. In the conviction that major "breakthroughs" in cancer research can best be achieved by cooperation between clinicians and investigators in the basic sciences, our approach has been a multidisciplinal one, in which surgeons, radiotherapists, pathologists, biochemists, biologists, and physicists have worked together. Herein will be presented some of the investigative References 1. Bierman, H. R.; Byron, R. L., Jr.; Miller, E. R., and Shimkin, M. B.: The Effects of Intra-Arterial Administration of Nitrogen Mustard, Fifth International Congress of Cancer , 1950, Paris, Hermann, p. 186 2. abstracted in Amer. J. Med. 8:535, 1950. 3. Creech, O., Jr.; Krementz, E. T.; Ryan, R. F., and Winblad, J. N.: Chemotherapy of Cancer: Regional Perfusion Utilizing an Extra-Corporeal Circuit , Ann. Surg. 148:616, 1958.Crossref 4. Creech, O., Jr.; Ryan, R. F., and Krementz, E. T.: Treatment of Melanoma by Isolation-Perfusion Technique , J.A.M.A. 169:339, 1959.Crossref 5. Klatt, O.; Griffin, A. C., and Stehlin, J. S., Jr.: Method for Determination of Phenylalanine Mustard and Related Alkylating Agents in Blood , Proc. Soc. Exp. Biol. Med. 104:629, 1960.Crossref 6. Klopp, C. T.; Alford, T. C.; Bateman, J.; Berry, G. N., and Winship, T.: Fractionated Intra-Arterial Cancer Chemotherapy with Methyl-Bis-Amine Hydrochloride: A Preliminary Report , Ann. Surg. 132:811, 1950.Crossref 7. Klopp, C. T.; Bateman, J.; Berry, G. N.; Alford, T. C., and Winship, T.: Fractionated Regional Cancer Chemotherapy , Cancer Res. 10:229, 1950. 8. Milner, A. N., and Stehlin, J. S., Jr.: Urinary Excretion Patterns of Patients Following Administration of Alkylating Agents by Regional Perfusion Technic , Proc. Amer. Ass. Cancer Res. (Abstr.) 3:134, 1960. 9. Milner, A. N., and Stehlin, J. S., Jr.: Studies of Carbohydrate Metabolism of Isolated Areas During Regional Perfusion for Cancer , Proc. Amer. Ass. Cancer Res. (Abstr.) 3:252, 1961. 10. Rose, G. G., and Stehlin, J. S., Jr.: The Golgi Complex and Melanin Elaboration of Human Melanomes in Tissue Culture, Cancer Res., to be published. 11. Stehlin, J. S., Jr.; Clark, R. L., Jr., and Dewey, W. C.: Continuous Monitoring of Leakage During Regional Perfusion , A.M.A. Arch. Surg. 83:943, 1961.Crossref 12. Stehlin, J. S., Jr.; Clark, R. L., Jr.; Smith, J. L., Jr., and White, E. C.: Malignant Melanoma of the Extremities: Experiences with Conventional Therapy, A New Surgical and Chemotherapeutic Approach with Regional Perfusion , Cancer 13:55, 1960.Crossref 13. Stehlin, J. S., Jr.; Clark, R. L., Jr.; White, E. C.; Healey, J. E., Jr; Dewey, W. C., and Beerstecher, S: The Leakage Factor in Regional Perfusion with Chemotherapeutic Agents , A.M.A. Arch. Surg. 80:934, 1960.Crossref 14. Stehlin, J. S., Jr.; Clark, R. L., Jr.; White, E. C.; Smith, J. L., Jr.; Griffin, A. C.; Jesse, R. H., Jr., and Healey, J. E., Jr.: Regional Chemotherapy for Cancer: Experiences with 116 Perfusions , Ann. Surg. 151:605, 1960.Crossref 15. Sullivan, R. D.; Miller, E., and Sikes, M. P.: Antimetabolite-Metabolite Combination Cancer Chemotherapy , Cancer 12:1248, 1959.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Jul 1, 1962

References