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Experience with Benactyzine Hydrochloride (Suavitil) in Dermatologic Practice

Experience with Benactyzine Hydrochloride (Suavitil) in Dermatologic Practice Abstract Benactyzine hydrochloride (Suavitil) is a member of that group of anticholinergic substances, several of which have selective activity upon various functions of the brain. This hydrochloride of the diethylaminoethyl ester of benzilic acid is represented by the following structural formula: The drug, first prepared in Switzerland in 1936,* was recently studied by investigators in Scandinavia, Denmark, and England.1-7 Responses of laboratory animals (in which experimental neuroses were produced by various techniques), and of human subjects and patients, supported the claim that benactyzine hydrochloride, in persons with and without psychological disorders reduces autonomic reaction to induced emotion, thereby producing a state of emotional and physical relaxation, without drowsiness. Benactyzine hydrochloride raises the threshold for external stimuli, so that the patient, in a state of tension arising from excessive strain, no longer reacts to stimuli which previously would have provoked marked irritation. He feels as References 1. Swiss patent 183,065 (1936). 2. Jacobsen, E., and Skaarup, Y.: Experimental Induction of Conflict-Behaviour in Cats: Its Use in Pharmacological Investigations , Acta pharmacol. et toxicol. 11:117-124, 1955.Crossref 3. Jacobsen, E., and Skaarup, Y.: Experimental Induction of Conflict-Behaviour in Cats: The Effect of Some Anticholinergic Compounds , Acta pharmacol. et toxicol. 11:125-134, 1955.Crossref 4. Jacobsen, E., and Sonne, E.: The Effect of Benzilic Acid Diethylaminoethylester Hydrochloride (Benactyzine) on Stress-Induced Behaviour in the Rat , Acta pharmacol. et toxicol. 11:135-147, 1955.Crossref 5. Holten, C. H., and Sonne, E.: Action of a Series of Benactyzine Derivatives and Other Compounds on Stress-Induced Behaviour in the Rat . Acta pharmacol. et toxicol. 11:148-155, 1955.Crossref 6. Larsen, V.: The General Pharmacology of Benzilic Acid Diethylaminoethylester Hydrochloride (Benactyzine NFN, Suavitil, Parasan) , Acta pharmacol. et toxicol. 11:405-420, 1955.Crossref 7. Jacobsen, E., and Sonne, E.: The Effect of Benactyzine on the Conditioned Responses in the Rat , Acta pharmacol. et toxicol. 12:310-320, 1956.Crossref 8. Holten, C. H., and Larsen, V.: The Potentiating Effect of Benactyzine Derivatives and Some Other Compounds on Evipal Anaesthesia in Mice , Acta pharmacol. et toxicol. 12:345-363, 1956. 9. Lands, A. M.; Nash, V. L., and Hooper, K. Z.: Relationship Between Chemical Structure and Spasmolytic Action of Some New Anticholinergic Esters , J. Pharmacol. & Exper. Therap. 86:129-137 ( (Feb.) ) 1946. 10. Berger, F. M.; Hendley, C. D., and Lynes, T. E.: Pharmacology of the Pychotherapeutic Drug Benactyzine (β-Diethylaminoethyl Benzilate Hydrochloride) , Proc. Soc. Exper. Biol. & Med. 92:563-566, 1956. 11. Coady, A., and Jewesbury, E. C. O.: A Clinical Trial of Benactyzine Hydrochloride ("Suavitil") as a Physical Relaxant , Brit. M. J. 1:485-487 ( (March 3) ) 1956. 12. Davies, E. B.: A New Drug to Relieve Anxiety , Brit. M. J. 1:480-484 ( (March 3) ) 1956. 13. Raymond, M. J., and Lucas, C. J.: Benactyzine in Psychoneurosis, with a Note on the E. E. G. Changes in Normal Subjects , Brit. M. J. 1:952-954 ( (April 28) ) 1956. 14. Scott, P. A. L.; Grimshaw, L., and Molony, H. M. P.: Hypotensive Episodes Following Treatment with Meprobamate , Lancet 2:1158 ( (Dec. 1) ) 1956. 15. Whitelaw, M. J.: Delay in Ovulation and Menstruation Induced by Chlorpromazine , J. Clin. Endocrinol. 16:972 ( (July) ) 1956. 16. DeFeo, V. J., and Reynolds, S. R. M.: Modification of the Menstrual Cycle in Rhesus Monkeys by Reserpine . Science 124:726-727 ( (Oct. 19) ) 1956. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Experience with Benactyzine Hydrochloride (Suavitil) in Dermatologic Practice

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Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1957.01550220074015
Publisher site
See Article on Publisher Site

Abstract

Abstract Benactyzine hydrochloride (Suavitil) is a member of that group of anticholinergic substances, several of which have selective activity upon various functions of the brain. This hydrochloride of the diethylaminoethyl ester of benzilic acid is represented by the following structural formula: The drug, first prepared in Switzerland in 1936,* was recently studied by investigators in Scandinavia, Denmark, and England.1-7 Responses of laboratory animals (in which experimental neuroses were produced by various techniques), and of human subjects and patients, supported the claim that benactyzine hydrochloride, in persons with and without psychological disorders reduces autonomic reaction to induced emotion, thereby producing a state of emotional and physical relaxation, without drowsiness. Benactyzine hydrochloride raises the threshold for external stimuli, so that the patient, in a state of tension arising from excessive strain, no longer reacts to stimuli which previously would have provoked marked irritation. He feels as References 1. Swiss patent 183,065 (1936). 2. Jacobsen, E., and Skaarup, Y.: Experimental Induction of Conflict-Behaviour in Cats: Its Use in Pharmacological Investigations , Acta pharmacol. et toxicol. 11:117-124, 1955.Crossref 3. Jacobsen, E., and Skaarup, Y.: Experimental Induction of Conflict-Behaviour in Cats: The Effect of Some Anticholinergic Compounds , Acta pharmacol. et toxicol. 11:125-134, 1955.Crossref 4. Jacobsen, E., and Sonne, E.: The Effect of Benzilic Acid Diethylaminoethylester Hydrochloride (Benactyzine) on Stress-Induced Behaviour in the Rat , Acta pharmacol. et toxicol. 11:135-147, 1955.Crossref 5. Holten, C. H., and Sonne, E.: Action of a Series of Benactyzine Derivatives and Other Compounds on Stress-Induced Behaviour in the Rat . Acta pharmacol. et toxicol. 11:148-155, 1955.Crossref 6. Larsen, V.: The General Pharmacology of Benzilic Acid Diethylaminoethylester Hydrochloride (Benactyzine NFN, Suavitil, Parasan) , Acta pharmacol. et toxicol. 11:405-420, 1955.Crossref 7. Jacobsen, E., and Sonne, E.: The Effect of Benactyzine on the Conditioned Responses in the Rat , Acta pharmacol. et toxicol. 12:310-320, 1956.Crossref 8. Holten, C. H., and Larsen, V.: The Potentiating Effect of Benactyzine Derivatives and Some Other Compounds on Evipal Anaesthesia in Mice , Acta pharmacol. et toxicol. 12:345-363, 1956. 9. Lands, A. M.; Nash, V. L., and Hooper, K. Z.: Relationship Between Chemical Structure and Spasmolytic Action of Some New Anticholinergic Esters , J. Pharmacol. & Exper. Therap. 86:129-137 ( (Feb.) ) 1946. 10. Berger, F. M.; Hendley, C. D., and Lynes, T. E.: Pharmacology of the Pychotherapeutic Drug Benactyzine (β-Diethylaminoethyl Benzilate Hydrochloride) , Proc. Soc. Exper. Biol. & Med. 92:563-566, 1956. 11. Coady, A., and Jewesbury, E. C. O.: A Clinical Trial of Benactyzine Hydrochloride ("Suavitil") as a Physical Relaxant , Brit. M. J. 1:485-487 ( (March 3) ) 1956. 12. Davies, E. B.: A New Drug to Relieve Anxiety , Brit. M. J. 1:480-484 ( (March 3) ) 1956. 13. Raymond, M. J., and Lucas, C. J.: Benactyzine in Psychoneurosis, with a Note on the E. E. G. Changes in Normal Subjects , Brit. M. J. 1:952-954 ( (April 28) ) 1956. 14. Scott, P. A. L.; Grimshaw, L., and Molony, H. M. P.: Hypotensive Episodes Following Treatment with Meprobamate , Lancet 2:1158 ( (Dec. 1) ) 1956. 15. Whitelaw, M. J.: Delay in Ovulation and Menstruation Induced by Chlorpromazine , J. Clin. Endocrinol. 16:972 ( (July) ) 1956. 16. DeFeo, V. J., and Reynolds, S. R. M.: Modification of the Menstrual Cycle in Rhesus Monkeys by Reserpine . Science 124:726-727 ( (Oct. 19) ) 1956.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Oct 1, 1957

References