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Experience With a Modified Rubella Hemagglutination Inhibition Antibody Test

Experience With a Modified Rubella Hemagglutination Inhibition Antibody Test This report confirms the value of a modification of the rubella hemagglutination inhibition (HI) antibody test which has eliminated the source of a troublesome problem, the random, unpredictable appearance of false positive results caused by inadequate removal of nonspecific serum inhibitors of hemagglutination. The modification consists of pretreating the test sera with a solution of manganese chloride and heparin sodium instead of kaolin suspension. The procedure is also more sensitive, rapid, and convenient, even in the hands of less experienced personnel, and should remove the last technical barrier to widespread availability of laboratory serodiagnosis for rubella. Furthermore, its use with 2-mercaptoethanol extends the range for accurate retrospective diagnosis of recent rubella. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Experience With a Modified Rubella Hemagglutination Inhibition Antibody Test

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1969.03150140041004
Publisher site
See Article on Publisher Site

Abstract

This report confirms the value of a modification of the rubella hemagglutination inhibition (HI) antibody test which has eliminated the source of a troublesome problem, the random, unpredictable appearance of false positive results caused by inadequate removal of nonspecific serum inhibitors of hemagglutination. The modification consists of pretreating the test sera with a solution of manganese chloride and heparin sodium instead of kaolin suspension. The procedure is also more sensitive, rapid, and convenient, even in the hands of less experienced personnel, and should remove the last technical barrier to widespread availability of laboratory serodiagnosis for rubella. Furthermore, its use with 2-mercaptoethanol extends the range for accurate retrospective diagnosis of recent rubella.

Journal

JAMAAmerican Medical Association

Published: Jan 6, 1969

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