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Exophthalmos Induced by Steroids

Exophthalmos Induced by Steroids Abstract Exophthalmos has been found in 6% to 8% of Cushing's disease with elevated endogenous steroid production. Four cases of exophthalmos associated with prolonged high doses of exogenous steroids are presented. Prior to steroid therapy, these patients exhibited no signs of exophthalmos. They were euthyroid with normal thyroid function studies while on steroid therapy. One case demonstrated a reduction of her exophthalmos after her steroid dosage was markedly decreased. Other known complications of steroid therapy including hyperglycemia, posterior subcapsular cataracts, and elevated intraocular tensions were found. The finding of exophthalmos presents a previously unreported complication of steroid therapy. References 1. Essex, H.E.: Exophthalmos in Hypophysectomized and Cortisone-Treated Albino Rats , Amer J Physiol 181:375, 1955. 2. Williams, A.W.: Exophthalmos in Cortisone-Treated Experimental Animals , Brit J Exp Path 34:621 ( (Dec) ) 1953. 3. Alterman, K., and Greenberg. S.M.: Experimental Exophthalmos Produced by Cortisone , Arch Ophthal 51:822, 1954.Crossref 4. Boas, N.F., and Scow, R.O.: Apparent Exophthalmos in the Rat Following Cortisone Treatment or Thyroidectomy , Endocrinology , 55:148, 1954.Crossref 5. Williams, A.W.: Pathogenesis of Cortisone-Induced Exophthalmos in Guinea-Pigs , Brit J Exp Path 36:245, 1955. 6. Barraquer, J. and Canadell, J.M.: Enhancing Effect of Corticotropin , Amer J Ophthal 48:803, 1959. 7. Plotz, C.M.; Knowlton, A.I.; and Ragan C.: The Natural History of Cushing's Syndrome , Amer J Med 13:597, 1952.Crossref 8. Morgan, D.C., and Mason, A.S.: Exophthalmos in Cushing's Syndrome , Brit Med J 2:481, 1958.Crossref 9. Schwarz, F.; Der Kinderen, P.J.; and Houtstra-Lanz, M.: Exophthalmos-Producing Activity in the Serum and in the Pituitary of Patients With Cushing's Syndrome and Acromegaly , J Clin Endocr 22:718 ( (July) ) 1962.Crossref 10. Kinsell, L.W.; Partridge, J.W.; and Foreman, N.: The Use of ACTH and Cortisone in the Treatment and in the Differential Diagnosis of Malignant Exophthalmos: A Preliminary Report , Ann Int Med 38:913, 1953.Crossref 11. Rubin, I.L., and Billet, E.W.: Treatment of Malignant Exophthalmos With ACTH and Cortisone , New York J Med 54:2991, 1954. 12. Panel appointed by the Medical Research Council: Cortisone in Exophthalmos , Lancet , 268:6, 1955. 13. Smelser, G.K.: Relation of Steroid Hormones to the Development of Experimental Exophthalmos , Amer J Ophthal 34 part 2:87 (No. (5) ) 1951. 14. Jeffries, W.M.: Studies of the Relationship of the Thyrotropic, Exophthalmic, and Fat-Mobilizing Principles of Pituitary Extract , J Clin Endocr 9:937, 1949.Crossref 15. Ludwig, A.W.; Boas, N.F.; and Softer, L.J.: Role of Mucipolysaccharides in the Pathogenesis of Experimental Exophthalmos . Proc Soc Exper Biol Med 73:137, 1950.Crossref 16. Furth, E.D., et al: Exophthalmos After Pituitary Ablation , J Clin Endocr 22:518, 1962.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1967.00980020581003
Publisher site
See Article on Publisher Site

Abstract

Abstract Exophthalmos has been found in 6% to 8% of Cushing's disease with elevated endogenous steroid production. Four cases of exophthalmos associated with prolonged high doses of exogenous steroids are presented. Prior to steroid therapy, these patients exhibited no signs of exophthalmos. They were euthyroid with normal thyroid function studies while on steroid therapy. One case demonstrated a reduction of her exophthalmos after her steroid dosage was markedly decreased. Other known complications of steroid therapy including hyperglycemia, posterior subcapsular cataracts, and elevated intraocular tensions were found. The finding of exophthalmos presents a previously unreported complication of steroid therapy. References 1. Essex, H.E.: Exophthalmos in Hypophysectomized and Cortisone-Treated Albino Rats , Amer J Physiol 181:375, 1955. 2. Williams, A.W.: Exophthalmos in Cortisone-Treated Experimental Animals , Brit J Exp Path 34:621 ( (Dec) ) 1953. 3. Alterman, K., and Greenberg. S.M.: Experimental Exophthalmos Produced by Cortisone , Arch Ophthal 51:822, 1954.Crossref 4. Boas, N.F., and Scow, R.O.: Apparent Exophthalmos in the Rat Following Cortisone Treatment or Thyroidectomy , Endocrinology , 55:148, 1954.Crossref 5. Williams, A.W.: Pathogenesis of Cortisone-Induced Exophthalmos in Guinea-Pigs , Brit J Exp Path 36:245, 1955. 6. Barraquer, J. and Canadell, J.M.: Enhancing Effect of Corticotropin , Amer J Ophthal 48:803, 1959. 7. Plotz, C.M.; Knowlton, A.I.; and Ragan C.: The Natural History of Cushing's Syndrome , Amer J Med 13:597, 1952.Crossref 8. Morgan, D.C., and Mason, A.S.: Exophthalmos in Cushing's Syndrome , Brit Med J 2:481, 1958.Crossref 9. Schwarz, F.; Der Kinderen, P.J.; and Houtstra-Lanz, M.: Exophthalmos-Producing Activity in the Serum and in the Pituitary of Patients With Cushing's Syndrome and Acromegaly , J Clin Endocr 22:718 ( (July) ) 1962.Crossref 10. Kinsell, L.W.; Partridge, J.W.; and Foreman, N.: The Use of ACTH and Cortisone in the Treatment and in the Differential Diagnosis of Malignant Exophthalmos: A Preliminary Report , Ann Int Med 38:913, 1953.Crossref 11. Rubin, I.L., and Billet, E.W.: Treatment of Malignant Exophthalmos With ACTH and Cortisone , New York J Med 54:2991, 1954. 12. Panel appointed by the Medical Research Council: Cortisone in Exophthalmos , Lancet , 268:6, 1955. 13. Smelser, G.K.: Relation of Steroid Hormones to the Development of Experimental Exophthalmos , Amer J Ophthal 34 part 2:87 (No. (5) ) 1951. 14. Jeffries, W.M.: Studies of the Relationship of the Thyrotropic, Exophthalmic, and Fat-Mobilizing Principles of Pituitary Extract , J Clin Endocr 9:937, 1949.Crossref 15. Ludwig, A.W.; Boas, N.F.; and Softer, L.J.: Role of Mucipolysaccharides in the Pathogenesis of Experimental Exophthalmos . Proc Soc Exper Biol Med 73:137, 1950.Crossref 16. Furth, E.D., et al: Exophthalmos After Pituitary Ablation , J Clin Endocr 22:518, 1962.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: May 1, 1967

References