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Excimer Laser Ablation of the Lens

Excimer Laser Ablation of the Lens Abstract • Ablation of the bovine crystalline lens was studied using radiation from an excimer laser at four ultraviolet wave lengths as follows: 193 nm (argon fluoride), 248 nm (krypton fluoride), 308 nm (xenon chloride), and 351 nm (xenon fluoride). The ablation process was quantitated by measuring mass ablated with an electronic balance, and characterized by examining ablation craters with scanning electron microscopy. The highest ablation rate was observed at 248 nm with lower rates at 193 and 308 nm. No ablation was observed at 351 nm. Scanning electron microscopy revealed the smoothest craters at 193 nm while at 248 nm there was vacuolization in the crater walls and greater disruption of surrounding tissue. The craters made at 308 nm did not have as smooth a contour as the 193-nm lesions. The spectral absorbance of the bovine lens was calculated at the wavelengths used for ablation and correlated with ablation rates and thresholds. High peak-power, pulsed ultraviolet laser radiation may have a role in surgical removal of the lens. References 1. Trokel SL, Srinivasan R, Braren B: Excimer laser surgery of the cornea . Am J Ophthalmol 1983;96:710-715. 2. Puliafito CA, Steinert RF, Deutsch TF, et al: Excimer laser ablation of the cornea and lens . Ophthalmology 1985;92:741-748.Crossref 3. Krueger RR, Trokel SL: Quantitation of corneal ablation by ultraviolet laser light . Arch Ophthalmol 1985;103:1741-1742.Crossref 4. Peyman GA, Kuszak JR, Weckstrom K, et al: Effects of XeCl excimer laser on the eyelid and anterior segment structures . Arch Ophthalmol 1986;104:118-122.Crossref 5. Pellin MJ, Williams GA, Young CE, et al: Endoexcimer laser intraocular ablative photodecomposition . Am J Ophthalmol 1985;99:483-484. 6. Lane RJ, Linsker R, Wynne JJ, et al: Ultraviolet-laser ablation of skin . Arch Dermatol 1985;121:609-617.Crossref 7. Grundfest WS, Litvack IF, Morgenstern L, et al: Effect of laser irradiation on human atherosclerotic aorta: Amelioration of laser-induced thermal damage. Paper FL-2, technical digest, Conference on Laser and Electro-optics, Anaheim, Calif, June 19-22, 1984. 8. Linsker R, Srinivasan R, Wynne JJ, et al: Far-ultraviolet laser ablation of atherosclerotic lesions . Lasers Surg Med 1984;4:201-206.Crossref 9. Taylor RS, Singleton DL, Paraskevopoulos G, et al: Dependence of excimer laser ablation of human artery wall on wavelength and optical pulse duration. Technical digest, Conference on Laser and Electro-optics. San Francisco, June 9-13, 1986, pp 129a-129g. 10. Marshall J, Trokel SL, Rothery S, et al: An ultrastructural study of corneal incisions induced by an excimer laser at 193 nm . Ophthalmology 1985;92:749-758.Crossref 11. Lane RJ, Wynne JJ, Geronemus RG: Ultraviolet laser ablation of skin: Healing studies and thermal model. Lasers Surg Med, in press. 12. Prince M, Oseroff A, Margolis R, et al: Selective ablation of plaque with pulsed dyelasers. Technical digest, Conference on Laser and Electro-optics. San Francisco, June 9-13,1986, pp 58a-58e. 13. Srinivasan R, Mayne-Banton V: Self-developing photoetching of poly(ethylene terephthalate) films by far-ultraviolet excimer laser radiation . Appl Phys Lett 1983;41:576-578.Crossref 14. Srinivasan R, Braren B: Ablative photodecomposition of polymer films by pulsed farultraviolet (193 nm) laser radiation: Dependence of etch depth on experimental conditions . J Polym Sci Polym Chem Ed 1984;22:2601-2609.Crossref 15. Lerman S: Radiant Energy and the Eye . New York, Macmillan Publishing Co Inc, 1980, p 164. 16. Dillon J: Photochemical mechanisms in the lens , in Maisel H (ed): The Ocular Lens . New York, Marcel Dekker Inc, 1985, p 350. 17. Sun M, Zigman S: Isolation and identification of tryptophan photo-products from aqueous solutions of tryptophan exposed to near-UV light . Photochem Photobiol 1978;29:893-897.Crossref 18. Borkman RF, Hibbard LB, Kirk NJ: Lens damage from 337.1-nm laser radiation . Lens Res 1985;2:109-120. 19. Lerman S, Borkman R: Spectroscopic evaluation and classification of the normal, aging, and cataractous lens . Ophthalmic Res 1976;8:335-353.Crossref 20. Marshall J, Sliney DH: Endoexcimer laser intraocular ablative photodecomposition . Am J Ophthalmol 1986;101:130. 21. Olson L, Marshall J, Rice N: Effects of ultrasound on the corneal endothelium: I. The acute lesion . Br J Ophthalmol 1978;62:134-144.Crossref 22. Parel J-M, Gelender H, Trefers WF, et al: Phaco-Ersatz: Cataract surgery designed to preserve accommodation . Graefes Arch Clin Exp Ophthalmol 1986;224:158-162.Crossref 23. Keates R, Genstler D, Tarabichi S: Ultraviolet light transmission of the lens capsule . Ophthalmic Surg 1982;13:374-376. 24. Van Heyningen R: Fluorescent derivatives of 3-hydroxydynurenine in the lens of man, baboons, and the grey squirrel . Biochem J 1971;123:30-31. 25. Cooper G, Robson J: The yellow colour of the lens of man and other primates . J Physiol 1969;203:411-417. 26. Zigman S: Photobiology of the lens , in Maisel H (ed): The Ocular Lens . New York, Marcel Dekker Inc, 1985, p 305. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1986.01050240099048
Publisher site
See Article on Publisher Site

Abstract

Abstract • Ablation of the bovine crystalline lens was studied using radiation from an excimer laser at four ultraviolet wave lengths as follows: 193 nm (argon fluoride), 248 nm (krypton fluoride), 308 nm (xenon chloride), and 351 nm (xenon fluoride). The ablation process was quantitated by measuring mass ablated with an electronic balance, and characterized by examining ablation craters with scanning electron microscopy. The highest ablation rate was observed at 248 nm with lower rates at 193 and 308 nm. No ablation was observed at 351 nm. Scanning electron microscopy revealed the smoothest craters at 193 nm while at 248 nm there was vacuolization in the crater walls and greater disruption of surrounding tissue. The craters made at 308 nm did not have as smooth a contour as the 193-nm lesions. The spectral absorbance of the bovine lens was calculated at the wavelengths used for ablation and correlated with ablation rates and thresholds. High peak-power, pulsed ultraviolet laser radiation may have a role in surgical removal of the lens. References 1. Trokel SL, Srinivasan R, Braren B: Excimer laser surgery of the cornea . Am J Ophthalmol 1983;96:710-715. 2. Puliafito CA, Steinert RF, Deutsch TF, et al: Excimer laser ablation of the cornea and lens . Ophthalmology 1985;92:741-748.Crossref 3. Krueger RR, Trokel SL: Quantitation of corneal ablation by ultraviolet laser light . Arch Ophthalmol 1985;103:1741-1742.Crossref 4. Peyman GA, Kuszak JR, Weckstrom K, et al: Effects of XeCl excimer laser on the eyelid and anterior segment structures . Arch Ophthalmol 1986;104:118-122.Crossref 5. Pellin MJ, Williams GA, Young CE, et al: Endoexcimer laser intraocular ablative photodecomposition . Am J Ophthalmol 1985;99:483-484. 6. Lane RJ, Linsker R, Wynne JJ, et al: Ultraviolet-laser ablation of skin . Arch Dermatol 1985;121:609-617.Crossref 7. Grundfest WS, Litvack IF, Morgenstern L, et al: Effect of laser irradiation on human atherosclerotic aorta: Amelioration of laser-induced thermal damage. Paper FL-2, technical digest, Conference on Laser and Electro-optics, Anaheim, Calif, June 19-22, 1984. 8. Linsker R, Srinivasan R, Wynne JJ, et al: Far-ultraviolet laser ablation of atherosclerotic lesions . Lasers Surg Med 1984;4:201-206.Crossref 9. Taylor RS, Singleton DL, Paraskevopoulos G, et al: Dependence of excimer laser ablation of human artery wall on wavelength and optical pulse duration. Technical digest, Conference on Laser and Electro-optics. San Francisco, June 9-13, 1986, pp 129a-129g. 10. Marshall J, Trokel SL, Rothery S, et al: An ultrastructural study of corneal incisions induced by an excimer laser at 193 nm . Ophthalmology 1985;92:749-758.Crossref 11. Lane RJ, Wynne JJ, Geronemus RG: Ultraviolet laser ablation of skin: Healing studies and thermal model. Lasers Surg Med, in press. 12. Prince M, Oseroff A, Margolis R, et al: Selective ablation of plaque with pulsed dyelasers. Technical digest, Conference on Laser and Electro-optics. San Francisco, June 9-13,1986, pp 58a-58e. 13. Srinivasan R, Mayne-Banton V: Self-developing photoetching of poly(ethylene terephthalate) films by far-ultraviolet excimer laser radiation . Appl Phys Lett 1983;41:576-578.Crossref 14. Srinivasan R, Braren B: Ablative photodecomposition of polymer films by pulsed farultraviolet (193 nm) laser radiation: Dependence of etch depth on experimental conditions . J Polym Sci Polym Chem Ed 1984;22:2601-2609.Crossref 15. Lerman S: Radiant Energy and the Eye . New York, Macmillan Publishing Co Inc, 1980, p 164. 16. Dillon J: Photochemical mechanisms in the lens , in Maisel H (ed): The Ocular Lens . New York, Marcel Dekker Inc, 1985, p 350. 17. Sun M, Zigman S: Isolation and identification of tryptophan photo-products from aqueous solutions of tryptophan exposed to near-UV light . Photochem Photobiol 1978;29:893-897.Crossref 18. Borkman RF, Hibbard LB, Kirk NJ: Lens damage from 337.1-nm laser radiation . Lens Res 1985;2:109-120. 19. Lerman S, Borkman R: Spectroscopic evaluation and classification of the normal, aging, and cataractous lens . Ophthalmic Res 1976;8:335-353.Crossref 20. Marshall J, Sliney DH: Endoexcimer laser intraocular ablative photodecomposition . Am J Ophthalmol 1986;101:130. 21. Olson L, Marshall J, Rice N: Effects of ultrasound on the corneal endothelium: I. The acute lesion . Br J Ophthalmol 1978;62:134-144.Crossref 22. Parel J-M, Gelender H, Trefers WF, et al: Phaco-Ersatz: Cataract surgery designed to preserve accommodation . Graefes Arch Clin Exp Ophthalmol 1986;224:158-162.Crossref 23. Keates R, Genstler D, Tarabichi S: Ultraviolet light transmission of the lens capsule . Ophthalmic Surg 1982;13:374-376. 24. Van Heyningen R: Fluorescent derivatives of 3-hydroxydynurenine in the lens of man, baboons, and the grey squirrel . Biochem J 1971;123:30-31. 25. Cooper G, Robson J: The yellow colour of the lens of man and other primates . J Physiol 1969;203:411-417. 26. Zigman S: Photobiology of the lens , in Maisel H (ed): The Ocular Lens . New York, Marcel Dekker Inc, 1985, p 305.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Dec 1, 1986

References

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