Abstract Recent studies have suggested that sodium fluoride therapy may be an effective treatment for vertebral osteoporosis. Unfortunately, the high frequency of side effects may limit the use of this treatment modality. This report documents the repeated exacerbation of rheumatoid arthritis on three occasions after the initiation of sodium fluoride therapy. This apparent complication of sodium fluoride treatment may be mediated by stimulation of leukocyte production of reactive oxygen species and other mediators of the acute inflammatory response. We suggest that sodium fluoride should be used cautiously in patients with rheumatoid arthritis. (Arch Intern Med. 1991;151:783-784) References 1. Pak CYC, Sakhaee K, Zerwekh JE, Parcel C, Peterson R, Johnson K. Safe and effective treatment of osteoporosis with intermittent slow release sodium fluoride: augmentation of vertebral bone mass and inhibition of fractures . J Clin Endocrinol Metab. 1989;68:150-159.Crossref 2. Riggs BL, Seeman E, Hodgson SF, Taves DR, O'Fallon WM. Effect of the fluoride-calcium regimen on vertebral fracture occurrence in postmenopausal osteoporosis: comparison with conventional therapy . N Engl J Med. 1982;306:446-450.Crossref 3. Mamelle N, Meunier PJ, Dusan R, et al. Risk benefit ratio of sodium fluoride treatment in vertebral osteoporosis . Lancet. 1988;2:361-365.Crossref 4. Peck WA, chairman. Consensus conference: osteoporosis . JAMA . 1984;252:799-802.Crossref 5. Farley JR, Wergedal JE, Baylink DJ. Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone-forming cells . Science. 1983;222:330-332.Crossref 6. Anonymous. Fluoride and the treatment of osteoporosis . Lancet. 1984;1:547. 7. Lipsky PE. Rheumatoid arthritis . In: Braunwauld E, Isselbacher KJ, Petersdorf RG, Wilson JD, Martin JB, Franci AS, eds. Harrison's Principles of Internal Medicine. 11th ed. New York, NY: McGraw-Hill International Book Co; 1987:1423-1428. 8. Gabig TG, English D, Akard LP, Schell MJ. Regulation of neutrophil NADPH oxidase activation in a cell-free system by guanine nucleotides and fluoride: evidence for participation of a pertussis and cholera toxin—insensitive G protein . J Biol Chem. 1987;262:1685-1690. 9. Bell AL, Hurst NP, Nuki G. Effect of corticosteroid therapy on blood monocyte superoxide generation in rheumatoid arthritis: studies in vitro and ex vivo . Br J Rheumatol. 1986;25:366-371.Crossref 10. Heinecke JW, Baker L, Rosen H, Chait A. Superoxide-mediated modification of low-density lipoprotein by arterial smooth muscle cells . J Clin Invest. 1986;77:757-761.Crossref 11. Petrequin PR, Todd RF III, Devall LJ, Boxer LA, Curnutte JT III. Association between gelatinase release and increased plasma membrane expression of the Mol glycoprotein . Blood. 1987;69:605-610.
Archives of Internal Medicine – American Medical Association
Published: Apr 1, 1991
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera