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Exacerbation of Rheumatoid Arthritis by Sodium Fluoride Treatment of Osteoporosis

Exacerbation of Rheumatoid Arthritis by Sodium Fluoride Treatment of Osteoporosis Abstract Recent studies have suggested that sodium fluoride therapy may be an effective treatment for vertebral osteoporosis. Unfortunately, the high frequency of side effects may limit the use of this treatment modality. This report documents the repeated exacerbation of rheumatoid arthritis on three occasions after the initiation of sodium fluoride therapy. This apparent complication of sodium fluoride treatment may be mediated by stimulation of leukocyte production of reactive oxygen species and other mediators of the acute inflammatory response. We suggest that sodium fluoride should be used cautiously in patients with rheumatoid arthritis. (Arch Intern Med. 1991;151:783-784) References 1. Pak CYC, Sakhaee K, Zerwekh JE, Parcel C, Peterson R, Johnson K. Safe and effective treatment of osteoporosis with intermittent slow release sodium fluoride: augmentation of vertebral bone mass and inhibition of fractures . J Clin Endocrinol Metab. 1989;68:150-159.Crossref 2. Riggs BL, Seeman E, Hodgson SF, Taves DR, O'Fallon WM. Effect of the fluoride-calcium regimen on vertebral fracture occurrence in postmenopausal osteoporosis: comparison with conventional therapy . N Engl J Med. 1982;306:446-450.Crossref 3. Mamelle N, Meunier PJ, Dusan R, et al. Risk benefit ratio of sodium fluoride treatment in vertebral osteoporosis . Lancet. 1988;2:361-365.Crossref 4. Peck WA, chairman. Consensus conference: osteoporosis . JAMA . 1984;252:799-802.Crossref 5. Farley JR, Wergedal JE, Baylink DJ. Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone-forming cells . Science. 1983;222:330-332.Crossref 6. Anonymous. Fluoride and the treatment of osteoporosis . Lancet. 1984;1:547. 7. Lipsky PE. Rheumatoid arthritis . In: Braunwauld E, Isselbacher KJ, Petersdorf RG, Wilson JD, Martin JB, Franci AS, eds. Harrison's Principles of Internal Medicine. 11th ed. New York, NY: McGraw-Hill International Book Co; 1987:1423-1428. 8. Gabig TG, English D, Akard LP, Schell MJ. Regulation of neutrophil NADPH oxidase activation in a cell-free system by guanine nucleotides and fluoride: evidence for participation of a pertussis and cholera toxin—insensitive G protein . J Biol Chem. 1987;262:1685-1690. 9. Bell AL, Hurst NP, Nuki G. Effect of corticosteroid therapy on blood monocyte superoxide generation in rheumatoid arthritis: studies in vitro and ex vivo . Br J Rheumatol. 1986;25:366-371.Crossref 10. Heinecke JW, Baker L, Rosen H, Chait A. Superoxide-mediated modification of low-density lipoprotein by arterial smooth muscle cells . J Clin Invest. 1986;77:757-761.Crossref 11. Petrequin PR, Todd RF III, Devall LJ, Boxer LA, Curnutte JT III. Association between gelatinase release and increased plasma membrane expression of the Mol glycoprotein . Blood. 1987;69:605-610. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Exacerbation of Rheumatoid Arthritis by Sodium Fluoride Treatment of Osteoporosis

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Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1991.00400040121028
Publisher site
See Article on Publisher Site

Abstract

Abstract Recent studies have suggested that sodium fluoride therapy may be an effective treatment for vertebral osteoporosis. Unfortunately, the high frequency of side effects may limit the use of this treatment modality. This report documents the repeated exacerbation of rheumatoid arthritis on three occasions after the initiation of sodium fluoride therapy. This apparent complication of sodium fluoride treatment may be mediated by stimulation of leukocyte production of reactive oxygen species and other mediators of the acute inflammatory response. We suggest that sodium fluoride should be used cautiously in patients with rheumatoid arthritis. (Arch Intern Med. 1991;151:783-784) References 1. Pak CYC, Sakhaee K, Zerwekh JE, Parcel C, Peterson R, Johnson K. Safe and effective treatment of osteoporosis with intermittent slow release sodium fluoride: augmentation of vertebral bone mass and inhibition of fractures . J Clin Endocrinol Metab. 1989;68:150-159.Crossref 2. Riggs BL, Seeman E, Hodgson SF, Taves DR, O'Fallon WM. Effect of the fluoride-calcium regimen on vertebral fracture occurrence in postmenopausal osteoporosis: comparison with conventional therapy . N Engl J Med. 1982;306:446-450.Crossref 3. Mamelle N, Meunier PJ, Dusan R, et al. Risk benefit ratio of sodium fluoride treatment in vertebral osteoporosis . Lancet. 1988;2:361-365.Crossref 4. Peck WA, chairman. Consensus conference: osteoporosis . JAMA . 1984;252:799-802.Crossref 5. Farley JR, Wergedal JE, Baylink DJ. Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone-forming cells . Science. 1983;222:330-332.Crossref 6. Anonymous. Fluoride and the treatment of osteoporosis . Lancet. 1984;1:547. 7. Lipsky PE. Rheumatoid arthritis . In: Braunwauld E, Isselbacher KJ, Petersdorf RG, Wilson JD, Martin JB, Franci AS, eds. Harrison's Principles of Internal Medicine. 11th ed. New York, NY: McGraw-Hill International Book Co; 1987:1423-1428. 8. Gabig TG, English D, Akard LP, Schell MJ. Regulation of neutrophil NADPH oxidase activation in a cell-free system by guanine nucleotides and fluoride: evidence for participation of a pertussis and cholera toxin—insensitive G protein . J Biol Chem. 1987;262:1685-1690. 9. Bell AL, Hurst NP, Nuki G. Effect of corticosteroid therapy on blood monocyte superoxide generation in rheumatoid arthritis: studies in vitro and ex vivo . Br J Rheumatol. 1986;25:366-371.Crossref 10. Heinecke JW, Baker L, Rosen H, Chait A. Superoxide-mediated modification of low-density lipoprotein by arterial smooth muscle cells . J Clin Invest. 1986;77:757-761.Crossref 11. Petrequin PR, Todd RF III, Devall LJ, Boxer LA, Curnutte JT III. Association between gelatinase release and increased plasma membrane expression of the Mol glycoprotein . Blood. 1987;69:605-610.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Apr 1, 1991

References

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