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Evolving Issues in the Use of Antibiotics for the Treatment of Uncomplicated Appendicitis

Evolving Issues in the Use of Antibiotics for the Treatment of Uncomplicated Appendicitis Opinion EDITORIAL Evolving Issues in the Use of Antibiotics for the Treatment of Uncomplicated Appendicitis Peter C. Minneci, MD, MHSc; Katherine J. Deans, MD, MHSc Over the past decade there has been considerable discussion confirmed the safety and effectiveness of nonoperative man- regarding whether antibiotics alone should be offered as a agement of appendicitis (676 of 776 participants [87%] com- pleted 90-day follow-up), with a 90-day success rate of 71%. treatment option to patients with uncomplicated appendici- tis. Recent evidence has suggested the answer to this ques- Compared with surgery (656 of 776 participants [85%] com- tion is yes. Results from sev- pleted 90-day follow-up), nonoperative management was eral large trials, including the associated with decreased disability (5.3 vs 8.7 missed Related article Appendicitis Acuta (APPAC) worked days) and similar treatment-associated complications II trial reported in this issue of JAMA, have generated robust (3% vs 3%) and quality of life (European Quality of Life–5 evidence for the effectiveness and safety for nonoperative Dimensions scores at 30 days: 0.92 vs 0.91). management of uncomplicated appendicitis for both adults The APPAC II trial results published in this issue of JAMA 1-4 and children. further confirm and extend the effectiveness of antibiotics http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Evolving Issues in the Use of Antibiotics for the Treatment of Uncomplicated Appendicitis

JAMA , Volume 325 (4) – Jan 26, 2021

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Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2020.23607
Publisher site
See Article on Publisher Site

Abstract

Opinion EDITORIAL Evolving Issues in the Use of Antibiotics for the Treatment of Uncomplicated Appendicitis Peter C. Minneci, MD, MHSc; Katherine J. Deans, MD, MHSc Over the past decade there has been considerable discussion confirmed the safety and effectiveness of nonoperative man- regarding whether antibiotics alone should be offered as a agement of appendicitis (676 of 776 participants [87%] com- pleted 90-day follow-up), with a 90-day success rate of 71%. treatment option to patients with uncomplicated appendici- tis. Recent evidence has suggested the answer to this ques- Compared with surgery (656 of 776 participants [85%] com- tion is yes. Results from sev- pleted 90-day follow-up), nonoperative management was eral large trials, including the associated with decreased disability (5.3 vs 8.7 missed Related article Appendicitis Acuta (APPAC) worked days) and similar treatment-associated complications II trial reported in this issue of JAMA, have generated robust (3% vs 3%) and quality of life (European Quality of Life–5 evidence for the effectiveness and safety for nonoperative Dimensions scores at 30 days: 0.92 vs 0.91). management of uncomplicated appendicitis for both adults The APPAC II trial results published in this issue of JAMA 1-4 and children. further confirm and extend the effectiveness of antibiotics

Journal

JAMAAmerican Medical Association

Published: Jan 26, 2021

References

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