CLINICAL SCIENCES Evolution in Regression Patterns Following Chemoreduction for Retinoblastoma Melis Palamar, MD; Archana Thangappan, MD; Carol L. Shields, MD Objective: To evaluate the change in regression pat- period of 56 months (median, 48 months; range, 18-145 tern following chemoreduction and tumor consolida- months), there was no change in regression patterns clas- tion therapy (thermotherapy or cryotherapy) for retino- sified as type 0, 1, or 4. However, there was evolution of blastoma. regression pattern types 2 and 3. Over time, type 2 tumor scars either remained stable (41%) or evolved to type 4 Methods: Retrospective medical record analysis was (41%), 3 (9%), or 1 (9%) scars. Type 3 tumor scars re- completed for 557 retinoblastomas (239 eyes of 157 pa- mained stable (74%) or evolved to type 1 (26%) scars. tients) that were treated with chemoreduction and showed regression to 1 of 5 patterns (type 0, no visible remnant; Conclusion: Following chemoreduction and tumor con- type 1, completely calcified remnant; type 2, completely solidation therapy, retinoblastoma regression patterns noncalcified remnant; type 3, partially calcified rem- types 2 and 3 can slowly evolve over time into a slightly nant; and type 4, atrophic chorioretinal flat scar). Evo- different appearance, even
JAMA Ophthalmology – American Medical Association
Published: Jun 1, 2011
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