Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Evidence That Sunscreens Prevent UV Radiation-Induced Immunosuppression in Humans: Sunscreens Have Their Day in the Sun

Evidence That Sunscreens Prevent UV Radiation-Induced Immunosuppression in Humans: Sunscreens... Abstract IT has been known for over two decades that induction of malignant skin tumors in rodents by midrange UV radiation (UVB radiation, 280 to 320 nm) involves not only an oncogenic event within the epidermis but also specific immunologic changes that serve to prevent or inhibit a vigorous immune response against the incipient tumor by the host immune system.1 Ultraviolet B—induced tumors in mice are highly immunogenic and fail to grow when transplanted to syngeneic recipients.2-4 Indeed, the transplanted tumors are destroyed and immunologic memory against the transplanted tumor can be detected. This observation led to a series of studies aimed at understanding why these immunogenic tumors grow in the primary host. UV RADIATION INDUCES SPECIFIC IMMUNOLOGIC CHANGES IN MICE Experiments performed in the 1970s by Kripke2,3 and Roberts et al4 demonstrated that prolonged and repetitive exposure to UVB radiation results not only in the appearance References 1. Grabbe S, Granstein RD. Mechanisms of ultraviolet radiation carcinogenesis . Chem Immunol. 1994;58:291-313. 2. Kripke ML. Ultraviolet radiation and immunology: something new under the sun—presidential address . Cancer Res. 1994;54:6102-6105. 3. Kripke ML. Photoimmunology . Photochem Photobiol. 1990;52:919-924.Crossref 4. Roberts LK, Lynch DH, Samlowski WE, Daynes RA. Ultraviolet radiation and modulation . Immunol Ser. 1989;46:167-215. 5. Fisher MS, Kripke ML. Suppressor T lymphocytes control the development of primary skin cancer in ultraviolet-irradiation mice . Science. 1982;216:1133-1134.Crossref 6. Noonan FP, DeFabo EC, Kripke ML. Suppression of contact hypersensitivity by UV radiation and its relationship to UV-induced suppression of tumor immunity . Photochem Photobiol. 1981;34:683-689.Crossref 7. Ullrich SE. Suppression of the immune response to allogeneic histocompatibility antigens by a single exposure to ultraviolet radiation . Transplantation. 1986;42:287-291.Crossref 8. Elmets CA, Bergstresser PR, Tigelaar RE, Wood PJ, Streilein JW. Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation . J Exp Med. 1983;158:781-794.Crossref 9. Weston PA, Jensen PJ, Levy NL, Koren HS. Spontaneous cytotoxicity against virus-infected cells: relationship to NK against uninfected cell lines and to ADCC . J Immunol. 1981;126:1220-1224. 10. Cooper KD, Duraiswamy N, Hammerberg C, et al. Neutrophils, differentiated macrophages, and monocyte/macrophage antigen presenting cells infiltrate murine epidermis after UV injury . J Invest Dermatol. 1993;101:155-163.Crossref 11. Tan KC, Hosoi J, Grabbe S, Asahina A, Granstein RD. Epidermal cell presentation of tumor-associated antigens for induction of tolerance . J Immunol. 1994; 153:760-767. 12. Sullivan S, Bergstresser PR, Tigelaar RE, Streilein JW. Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells . J Immunol. 1986; 137:2460-2470. 13. Yoshikawa T, Kurimoto I, Streilein JW. Tumor necrosis factor-alpha mediates ultraviolet light B-enhanced expression of contact hypersensitivity . Immunology . 1992;76:264-271. 14. Shimizu T, Streilein JW. Local and systemic consequences of acute, low-dose ultraviolet B radiation are mediated by different immune regulatory mechanisms . Eur J Immunol. 1994;24:1765-1770.Crossref 15. Kim TY, Kripke ML, Ullrich SE. Immunosuppression by factors released from UV-irradiated epidermal cells: selective effects on the generation of contact and delayed hypersensitivity after exposure to UVA or UVB radiation . J Invest Dermatol. 1990;94:26-32.Crossref 16. Rivas JM, Ullrich SE. The role of IL-4, IL-10 and TNF-alpha in the immune suppression induced by ultraviolet radiation . J Leuk Biol. 1994;56:769-775. 17. Kang K, Hommersberg C, Meunier L, Cooper KD. CD11b+ macrophages that infiltrate human epidermis after in vivo ultraviolet exposure potently produce IL-10 and represent the major secretory source of epidermal IL-10 protein . J Immunol. 1994;153:5256-5264. 18. Enk CD, Sredni D, Blauvelt SI. Induction of IL-10 gene expression in human keratinocytes by UVB exposure in vivo and in vitro . J Immunol. 1995;154: 4851-4856. 19. Grabbe S, Bruvers S, Gallo RL, Knisely TL, Nazareno R, Granstein RD. Tumor antigen presentation by murine epidermal cells . J Immunol. 1991;146:3656-3661. 20. Grabbe S, Bruvers S, Lindgren AM, Hosoi J, Tan KC, Granstein RD. Tumor antigen presentation by epidermal antigen-presenting cells in the mouse: modulation by granulocyte-macrophage colony-stimulating factor, tumor necrosis factor alpha, and ultraviolet radiation . J Leukoc Biol. 1992;52:209-217. 21. Beissert S, Hosoi J, Grabbe S, Asahina A, Granstein RD. IL-10 inhibits tumor antigen presentation by epidermal antigen-presenting cells . J Immunol. 1995; 154:1280-1286. 22. Grabbe S, Bruvers S, Granstein RD. Interleukin 1 alpha but not transforming growth factor beta inhibits tumor antigen presentation by epidermal antigen-presenting cells . J Invest Dermatol. 1994;102:67-73.Crossref 23. Kripke ML, Cox PA, Alas LG, Yarosh DB. Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice . Proc Natl Acad Sci U S A. 1992;89:7516-7520.Crossref 24. Wolf P, Cox P, Yarosh DB, Kripke ML. Sunscreens and T4N5 liposomes differ in their ability to protect against ultraviolet-induced sunburn cell formation, alterations of dendritic epidermal cells, and local suppression of contact hypersensitivity . J Invest Dermatol. 1995;104:287-292.Crossref 25. Applegate LA, Ley RD, Alcalay J, Kripke ML. Identification of the molecular target for the suppression of contact hypersensitivity by ultraviolet radiation . J Exp Med. 1989;170:1117-1131.Crossref 26. Gilmour JW, Norval M. The effect of ultraviolet B irradiation, cis-urocanic acid and tumour necrosis factor-alpha on delayed hypersensitivity to herpes simplex virus . Photoderm Photoimmunol Photomed . 1992-93;9:255-261. 27. Noonan FP, De Fabo EC. Immunosuppression by ultraviolet B radiation: initiation by urocanic acid . Immunol Today. 1992;13:250-254.Crossref 28. Hoxtell EO, Mandel JS, Murray SS. Incidence of skin carcinoma after renal transplantation . Arch Dermatol. 1977;113:436-438.Crossref 29. Gupta AK, Cardella CJ, Haberman HF. Cutaneous malignant neoplasms in patients with renal transplants . Arch Dermatol. 1986;112:1288-1293.Crossref 30. King GN, Healy CM, Glover MT, et al. Increased prevalence of dysplastic and malignant lip lesions in renal-transplant recipients . N Engl J Med. 1995;332: 1052-1057.Crossref 31. Greene Ml, Young Tl, Clark WH Jr. Malignant melanoma in renal-transplant recipients . Lancet . 1981;1:1196-1199.Crossref 32. Yoshikawa T, Rae V, Bruins-Slot W, Van den Berg JW, Taylor JR, Streilein JW. Susceptibility to effects of UVB radiation on induction of contact hypersensitivity as a risk factor for skin cancer in humans . J Invest Dermatol. 1990; 95:530-636.Crossref 33. Cooper KD, Oberhelman L, Hamilton TA, et al. UV exposure reduces immunization rates and promotes tolerance to epicutaneous antigens in humans: relationship to dose, CDIa-DR+ epidermal macrophage induction, and Langerhans cell depletion . Proc Natl Acad Sci U S A. 1992;89:8497-8501.Crossref 34. Whitmore SE, Morison WL. Prevention of UVB-induced immunosuppression in humans by a high sun protection factor sunscreen . Arch Dermatol. 1995; 131:1128-1133.Crossref 35. Snyder DS, May M. Ability of PABA to protect mammalian skin from ultraviolet light-induced skin tumors and actinic damage . J Invest Dermatol. 1975;65: 543-546.Crossref 36. Thompson SC, Jolley D, Marks R. Reduction of solar keratoses by regular sunscreen use . N Engl J Med. 1993;329:1147-1151.Crossref 37. Reeve VE, Bosnic M, Boehm-Wilcox C, Ley RD. Differential protection by two sunscreens from UV radiation—induced immunosuppression . J Invest Dermatol. 1991;97:624-628.Crossref 38. Morison WL. The effect of a sunscreen containing para-aminobenzoic acid on the systemic immunologic alterations induced in mice by exposure to UVB radiation . J Invest Dermatol. 1984;83:405-408.Crossref 39. Wolf P, Yarosh DB, Kripke ML. Effects of sunscreens and a DNA excision repair enzyme on ultraviolet radiation-induced inflammation, immune suppression, and cyclobutane pyrimidine dimer formation in mice . J Invest Dermatol. 1993;101:523-527.Crossref 40. Fisher MS, Menter JM, Willis I. Ultraviolet radiation-induced suppression of contact hypersensitivity in relation to padimate 0 and oxybenzone . J Invest Dermatol. 1989;92:337-341.Crossref 41. Gurish MF, Roberts LK, Krueger GG, Daynes RA. The effect of various sunscreen agents on skin damage and the induction of tumor susceptibility in mice subjected to ultraviolet irradiation . J Invest Dermatol. 1981;76:246-251.Crossref 42. Morison WL, Kelley SP. Sunlight suppressing rejection of 280- to 320-nm UV-radiation—induced skin tumors in mice . J Natl Cancer Inst. 1985;74:525-527. 43. Wolf P, Donauho CK, Kripke ML. Effects of sunscreens on UV radiation— induced enhancement of melanoma growth in mice . J Natl Cancer Inst. 1994; 86:99-105.Crossref 44. Strickland FM, Pelley RP, Kripke ML. Prevention of ultraviolet radiationinduced suppression of contact and delayed hypersensitivity by Aloe barbadensis gel extract . J Invest Dermatol. 1994;102:197-204.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Evidence That Sunscreens Prevent UV Radiation-Induced Immunosuppression in Humans: Sunscreens Have Their Day in the Sun

Archives of Dermatology , Volume 131 (10) – Oct 1, 1995

Loading next page...
 
/lp/american-medical-association/evidence-that-sunscreens-prevent-uv-radiation-induced-YOmacrwSd0
Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1995.01690220109022
Publisher site
See Article on Publisher Site

Abstract

Abstract IT has been known for over two decades that induction of malignant skin tumors in rodents by midrange UV radiation (UVB radiation, 280 to 320 nm) involves not only an oncogenic event within the epidermis but also specific immunologic changes that serve to prevent or inhibit a vigorous immune response against the incipient tumor by the host immune system.1 Ultraviolet B—induced tumors in mice are highly immunogenic and fail to grow when transplanted to syngeneic recipients.2-4 Indeed, the transplanted tumors are destroyed and immunologic memory against the transplanted tumor can be detected. This observation led to a series of studies aimed at understanding why these immunogenic tumors grow in the primary host. UV RADIATION INDUCES SPECIFIC IMMUNOLOGIC CHANGES IN MICE Experiments performed in the 1970s by Kripke2,3 and Roberts et al4 demonstrated that prolonged and repetitive exposure to UVB radiation results not only in the appearance References 1. Grabbe S, Granstein RD. Mechanisms of ultraviolet radiation carcinogenesis . Chem Immunol. 1994;58:291-313. 2. Kripke ML. Ultraviolet radiation and immunology: something new under the sun—presidential address . Cancer Res. 1994;54:6102-6105. 3. Kripke ML. Photoimmunology . Photochem Photobiol. 1990;52:919-924.Crossref 4. Roberts LK, Lynch DH, Samlowski WE, Daynes RA. Ultraviolet radiation and modulation . Immunol Ser. 1989;46:167-215. 5. Fisher MS, Kripke ML. Suppressor T lymphocytes control the development of primary skin cancer in ultraviolet-irradiation mice . Science. 1982;216:1133-1134.Crossref 6. Noonan FP, DeFabo EC, Kripke ML. Suppression of contact hypersensitivity by UV radiation and its relationship to UV-induced suppression of tumor immunity . Photochem Photobiol. 1981;34:683-689.Crossref 7. Ullrich SE. Suppression of the immune response to allogeneic histocompatibility antigens by a single exposure to ultraviolet radiation . Transplantation. 1986;42:287-291.Crossref 8. Elmets CA, Bergstresser PR, Tigelaar RE, Wood PJ, Streilein JW. Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation . J Exp Med. 1983;158:781-794.Crossref 9. Weston PA, Jensen PJ, Levy NL, Koren HS. Spontaneous cytotoxicity against virus-infected cells: relationship to NK against uninfected cell lines and to ADCC . J Immunol. 1981;126:1220-1224. 10. Cooper KD, Duraiswamy N, Hammerberg C, et al. Neutrophils, differentiated macrophages, and monocyte/macrophage antigen presenting cells infiltrate murine epidermis after UV injury . J Invest Dermatol. 1993;101:155-163.Crossref 11. Tan KC, Hosoi J, Grabbe S, Asahina A, Granstein RD. Epidermal cell presentation of tumor-associated antigens for induction of tolerance . J Immunol. 1994; 153:760-767. 12. Sullivan S, Bergstresser PR, Tigelaar RE, Streilein JW. Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells . J Immunol. 1986; 137:2460-2470. 13. Yoshikawa T, Kurimoto I, Streilein JW. Tumor necrosis factor-alpha mediates ultraviolet light B-enhanced expression of contact hypersensitivity . Immunology . 1992;76:264-271. 14. Shimizu T, Streilein JW. Local and systemic consequences of acute, low-dose ultraviolet B radiation are mediated by different immune regulatory mechanisms . Eur J Immunol. 1994;24:1765-1770.Crossref 15. Kim TY, Kripke ML, Ullrich SE. Immunosuppression by factors released from UV-irradiated epidermal cells: selective effects on the generation of contact and delayed hypersensitivity after exposure to UVA or UVB radiation . J Invest Dermatol. 1990;94:26-32.Crossref 16. Rivas JM, Ullrich SE. The role of IL-4, IL-10 and TNF-alpha in the immune suppression induced by ultraviolet radiation . J Leuk Biol. 1994;56:769-775. 17. Kang K, Hommersberg C, Meunier L, Cooper KD. CD11b+ macrophages that infiltrate human epidermis after in vivo ultraviolet exposure potently produce IL-10 and represent the major secretory source of epidermal IL-10 protein . J Immunol. 1994;153:5256-5264. 18. Enk CD, Sredni D, Blauvelt SI. Induction of IL-10 gene expression in human keratinocytes by UVB exposure in vivo and in vitro . J Immunol. 1995;154: 4851-4856. 19. Grabbe S, Bruvers S, Gallo RL, Knisely TL, Nazareno R, Granstein RD. Tumor antigen presentation by murine epidermal cells . J Immunol. 1991;146:3656-3661. 20. Grabbe S, Bruvers S, Lindgren AM, Hosoi J, Tan KC, Granstein RD. Tumor antigen presentation by epidermal antigen-presenting cells in the mouse: modulation by granulocyte-macrophage colony-stimulating factor, tumor necrosis factor alpha, and ultraviolet radiation . J Leukoc Biol. 1992;52:209-217. 21. Beissert S, Hosoi J, Grabbe S, Asahina A, Granstein RD. IL-10 inhibits tumor antigen presentation by epidermal antigen-presenting cells . J Immunol. 1995; 154:1280-1286. 22. Grabbe S, Bruvers S, Granstein RD. Interleukin 1 alpha but not transforming growth factor beta inhibits tumor antigen presentation by epidermal antigen-presenting cells . J Invest Dermatol. 1994;102:67-73.Crossref 23. Kripke ML, Cox PA, Alas LG, Yarosh DB. Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice . Proc Natl Acad Sci U S A. 1992;89:7516-7520.Crossref 24. Wolf P, Cox P, Yarosh DB, Kripke ML. Sunscreens and T4N5 liposomes differ in their ability to protect against ultraviolet-induced sunburn cell formation, alterations of dendritic epidermal cells, and local suppression of contact hypersensitivity . J Invest Dermatol. 1995;104:287-292.Crossref 25. Applegate LA, Ley RD, Alcalay J, Kripke ML. Identification of the molecular target for the suppression of contact hypersensitivity by ultraviolet radiation . J Exp Med. 1989;170:1117-1131.Crossref 26. Gilmour JW, Norval M. The effect of ultraviolet B irradiation, cis-urocanic acid and tumour necrosis factor-alpha on delayed hypersensitivity to herpes simplex virus . Photoderm Photoimmunol Photomed . 1992-93;9:255-261. 27. Noonan FP, De Fabo EC. Immunosuppression by ultraviolet B radiation: initiation by urocanic acid . Immunol Today. 1992;13:250-254.Crossref 28. Hoxtell EO, Mandel JS, Murray SS. Incidence of skin carcinoma after renal transplantation . Arch Dermatol. 1977;113:436-438.Crossref 29. Gupta AK, Cardella CJ, Haberman HF. Cutaneous malignant neoplasms in patients with renal transplants . Arch Dermatol. 1986;112:1288-1293.Crossref 30. King GN, Healy CM, Glover MT, et al. Increased prevalence of dysplastic and malignant lip lesions in renal-transplant recipients . N Engl J Med. 1995;332: 1052-1057.Crossref 31. Greene Ml, Young Tl, Clark WH Jr. Malignant melanoma in renal-transplant recipients . Lancet . 1981;1:1196-1199.Crossref 32. Yoshikawa T, Rae V, Bruins-Slot W, Van den Berg JW, Taylor JR, Streilein JW. Susceptibility to effects of UVB radiation on induction of contact hypersensitivity as a risk factor for skin cancer in humans . J Invest Dermatol. 1990; 95:530-636.Crossref 33. Cooper KD, Oberhelman L, Hamilton TA, et al. UV exposure reduces immunization rates and promotes tolerance to epicutaneous antigens in humans: relationship to dose, CDIa-DR+ epidermal macrophage induction, and Langerhans cell depletion . Proc Natl Acad Sci U S A. 1992;89:8497-8501.Crossref 34. Whitmore SE, Morison WL. Prevention of UVB-induced immunosuppression in humans by a high sun protection factor sunscreen . Arch Dermatol. 1995; 131:1128-1133.Crossref 35. Snyder DS, May M. Ability of PABA to protect mammalian skin from ultraviolet light-induced skin tumors and actinic damage . J Invest Dermatol. 1975;65: 543-546.Crossref 36. Thompson SC, Jolley D, Marks R. Reduction of solar keratoses by regular sunscreen use . N Engl J Med. 1993;329:1147-1151.Crossref 37. Reeve VE, Bosnic M, Boehm-Wilcox C, Ley RD. Differential protection by two sunscreens from UV radiation—induced immunosuppression . J Invest Dermatol. 1991;97:624-628.Crossref 38. Morison WL. The effect of a sunscreen containing para-aminobenzoic acid on the systemic immunologic alterations induced in mice by exposure to UVB radiation . J Invest Dermatol. 1984;83:405-408.Crossref 39. Wolf P, Yarosh DB, Kripke ML. Effects of sunscreens and a DNA excision repair enzyme on ultraviolet radiation-induced inflammation, immune suppression, and cyclobutane pyrimidine dimer formation in mice . J Invest Dermatol. 1993;101:523-527.Crossref 40. Fisher MS, Menter JM, Willis I. Ultraviolet radiation-induced suppression of contact hypersensitivity in relation to padimate 0 and oxybenzone . J Invest Dermatol. 1989;92:337-341.Crossref 41. Gurish MF, Roberts LK, Krueger GG, Daynes RA. The effect of various sunscreen agents on skin damage and the induction of tumor susceptibility in mice subjected to ultraviolet irradiation . J Invest Dermatol. 1981;76:246-251.Crossref 42. Morison WL, Kelley SP. Sunlight suppressing rejection of 280- to 320-nm UV-radiation—induced skin tumors in mice . J Natl Cancer Inst. 1985;74:525-527. 43. Wolf P, Donauho CK, Kripke ML. Effects of sunscreens on UV radiation— induced enhancement of melanoma growth in mice . J Natl Cancer Inst. 1994; 86:99-105.Crossref 44. Strickland FM, Pelley RP, Kripke ML. Prevention of ultraviolet radiationinduced suppression of contact and delayed hypersensitivity by Aloe barbadensis gel extract . J Invest Dermatol. 1994;102:197-204.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Oct 1, 1995

References