Abstract • The hemagglutination inhibition (HI) serologic responses of 851 measlessusceptible infants and children to the live, further-attenuated measles virus vaccine were evaluated over a ten-year period. The response by age at 23-day intervals was determined. Infants inoculated at 12 through 14 months of age demonstrated seroconversion rates by HI assay comparable to those in infants and children inoculated at 15 months of age or older. This finding does not support the recent recommendation that routine active immunization with measles vaccine should be postponed until 15 months of age. We emphasize the possible consequence of electively leaving infants 12 through 14 months of age vulnerable to measles because of the current endemicity of this disease in the United States. We also present evidence for the reinstatement of infants 12 through 14 months of age into routine measles immunization programs and for the need to further evaluate the causes for vaccine failure in vaccinees after the loss of maternal antibody. (Am J Dis Child 132:164-166, 1978) References 1. Measles immunizations: New recommendations . Committee on Infectious Diseases of the American Academy of Pediatrics, 1976. 2. Measles vaccine . Public Health Service Advisory Committee on Immunization Practices, Morbidity and Mortality Weekly Report, 1976, pp 359-365. 3. Wilkins J, Wehrle PF, Portnoy B: Live, further attenuated rubeola vaccine: Serologic responses among term and low birth weight infants . Am J Dis Child 123:190-192, 1972.Crossref 4. Rosen L: Hemagglutination and hemagglutination-inhibition with measles virus . Virology 13:139-141, 1961.Crossref 5. Norrby EL: Hemagglutination by measles virus: IV. A simple procedure for production of high potency antigen for hemagglutination-inhibition (HI) tests . Proc Soc Exp Biol Med 111:814-818, 1962.Crossref 6. Krugman S, Giles JP, Friedman H, et al: Studies on immunity to measles . J Pediatr 66:471-488, 1965.Crossref 7. Waldmann TA: Disorders of immunoglobulin metabolism . N Engl J Med 281:1170-1176, 1969.Crossref 8. Cherry JD, Feigin RD, Shackelford PG, et al: A clinical and serologic study of 103 children with measles vaccine failure . J Pediatr 82:802-808, 1973.Crossref 9. Lerman SJ, Gold E: Measles in children previously vaccinated against measles . JAMA 216:1311-1314, 1971.Crossref 10. Wyll SA, Witte JJ: Measles in previously vaccinated children . JAMA 216:1306-1310, 1971.Crossref 11. Baratta RO, Ginter MC, Price MA, et al: Measles (rubeola) in previously immunized children . Pediatrics 46:397-402, 1970. 12. Linnemann CC Jr, Rotte TC, Schiff GM, et al: A seroepidemiologic study of a measles epidemic in a highly immunized population . Am J Epidemiol 95:238-246, 1972.
American Journal of Diseases of Children – American Medical Association
Published: Feb 1, 1978