Key PointsQuestionIs there an association between parameters of fluorodeoxyglucose F 18–labeled positron emission tomography and computed tomography (FDG-PET/CT) and prognosis among patients with surgically treated head and neck cancer? FindingsThis systematic review of 36 studies that included 3585 unique patients highlights the prognostic value of FDG-PET/CT parameters, especially volumetric parameters, as biomarkers of overall survival, disease-free survival, and distant metastasis among patients with surgically treated head and neck cancer. MeaningThe findings of this review suggest that FDG-PET/CT parameters may be used to identify patients with a higher risk of postsurgical disease progression who could then receive early therapeutic intensification to improve their prognosis without increasing iatrogenic toxic effects; however, further research is required to define a reproducible, reliable FDG-PET/CT–based prognostic model of patients’ mortality and recurrence risks.
JAMA Otolaryngology - Head & Neck Surgery – American Medical Association
Published: May 26, 2020
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