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Evaluation of Red Cell Equilibration in Hemorrhagic Shock

Evaluation of Red Cell Equilibration in Hemorrhagic Shock Abstract Introduction THE use of the animal model in studying shock in the laboratory has proved a valuable tool in understanding some of the pathophysiologic changes seen in the shock syndrome. However, attempts to verify experimental findings in the human counterpart often have been less than satisfactory.As a result, therapeutic principles derived from animal experimentation have not always been acceptable for application in a given clinical circumstance. Furthermore, greater significance may be placed upon reliable data gathered from the shock patient, as some dynamic changes in the animal model do not appear uniformly in deep shock. The most logical attitude, it would appear, is to approach the animal for investigation and the human for verification.Therefore, when experimental results are substantiated in the patient, any principle of mechanistic or therapeutic import will be sound. Bearing this approach in mind, investigation of the characteristics of red cell equilibration in dogs was References 1. Wiggers, C. J.: Physiology of Shock , New York: The Commonwealth Fund, 1950. 2. Shoemaker, W. C.: Studies on Viscosity Alterations in Shock , Arch Surg 87:355, 1963.Crossref 3. Gelin, L.-E.: Studies in Anemia of Injury , Acta Chir Scand (suppl 210) , pp 1-30, 1956. 4. Read, R. C.: Studies of Red Cell Volume and Turnover Using Radiochromium , New Eng J Med 250:1021, 1954.Crossref 5. Suzuki, F.; Baker, R. J.; and Shoemaker, W. C.: Red Cell and Plasma Volume Alterations After Hemorrhage and Trauma , Ann Surg 160:263, 1964.Crossref 6. Suzuki, F., and Shoemaker, W. C.: Effect of Low Viscosity Dextran on Red Cell Circulation in Hemorrhagic Shock , Surgery 55:304, 1964. 7. Baker, R. J., et al: Low Molecular Weight Dextran Therapy in Surgical Shock , Arch Surg 89:373, 1964.Crossref 8. Gelin, L.-E., and Shoemaker, W. C.: Hepatic Blood Flow and Microcirculatory Alterations Induced by Dextran of High and Low Viscosity , Surgery 49:713, 1961. 9. Gelin, L.-E.: in Shock: International Symposium , Berlin: Springer-Verlag, 1962, pp 332-347. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Evaluation of Red Cell Equilibration in Hemorrhagic Shock

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Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1965.01320100082013
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction THE use of the animal model in studying shock in the laboratory has proved a valuable tool in understanding some of the pathophysiologic changes seen in the shock syndrome. However, attempts to verify experimental findings in the human counterpart often have been less than satisfactory.As a result, therapeutic principles derived from animal experimentation have not always been acceptable for application in a given clinical circumstance. Furthermore, greater significance may be placed upon reliable data gathered from the shock patient, as some dynamic changes in the animal model do not appear uniformly in deep shock. The most logical attitude, it would appear, is to approach the animal for investigation and the human for verification.Therefore, when experimental results are substantiated in the patient, any principle of mechanistic or therapeutic import will be sound. Bearing this approach in mind, investigation of the characteristics of red cell equilibration in dogs was References 1. Wiggers, C. J.: Physiology of Shock , New York: The Commonwealth Fund, 1950. 2. Shoemaker, W. C.: Studies on Viscosity Alterations in Shock , Arch Surg 87:355, 1963.Crossref 3. Gelin, L.-E.: Studies in Anemia of Injury , Acta Chir Scand (suppl 210) , pp 1-30, 1956. 4. Read, R. C.: Studies of Red Cell Volume and Turnover Using Radiochromium , New Eng J Med 250:1021, 1954.Crossref 5. Suzuki, F.; Baker, R. J.; and Shoemaker, W. C.: Red Cell and Plasma Volume Alterations After Hemorrhage and Trauma , Ann Surg 160:263, 1964.Crossref 6. Suzuki, F., and Shoemaker, W. C.: Effect of Low Viscosity Dextran on Red Cell Circulation in Hemorrhagic Shock , Surgery 55:304, 1964. 7. Baker, R. J., et al: Low Molecular Weight Dextran Therapy in Surgical Shock , Arch Surg 89:373, 1964.Crossref 8. Gelin, L.-E., and Shoemaker, W. C.: Hepatic Blood Flow and Microcirculatory Alterations Induced by Dextran of High and Low Viscosity , Surgery 49:713, 1961. 9. Gelin, L.-E.: in Shock: International Symposium , Berlin: Springer-Verlag, 1962, pp 332-347.

Journal

Archives of SurgeryAmerican Medical Association

Published: Apr 1, 1965

References