LABORATORY SCIENCES Evaluation of Polyhexamethylene Biguanide (PHMB) as a Disinfectant for Adenovirus Eric G. Romanowski, MS; Kathleen A. Yates, BS; Katherine E. O’Connor, BS; Francis S. Mah, MD; Robert M. Q. Shanks, PhD; Regis P. Kowalski, MS, M(ASCP) Importance: Swimming pools can be a vector for trans- tions relative to controls were calculated. Virucidal mission of adenovirus ocular infections. Polyhexameth- (99.9%) decreases in mean adenovirus titers after PHMB ylene biguanide (PHMB) is a disinfectant used in swim- treatment were determined for each adenovirus type and ming pools and hot tubs. temperature tested. Objective: To determine whether PHMB is an effec- Results: At room temperature, 50 ppm of PHMB pro- tive disinfectant against ocular adenovirus serotypes at duced mean reductions in titers less than 1 log for all a concentration used to disinfect swimming pools and adenovirus types tested. At 40C, 50 ppm of PHMB pro- hot tubs. duced mean reductions in titers less than 1 log for 2 adenovirus types and greater than 1 but less than 3 log Design: In vitro laboratory study. for 7 of 9 adenovirus types. Interventions: The direct disinfecting activity of PHMB Conclusions and Relevance: At a concentration of was determined in triplicate assays
JAMA Ophthalmology – American Medical Association
Published: Apr 1, 2013
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