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Evaluation of Peripheral Circulation with Radioactive Iodinated Serum Albumin: A Preliminary Report

Evaluation of Peripheral Circulation with Radioactive Iodinated Serum Albumin: A Preliminary Report Abstract Methods which permit measurement of peripheral blood flow volume should prove valuable in the study of peripheral vascular diseases. A review of the voluminous literature on the subject indicates that most of the present techniques reflect an indirect estimation of the peripheral blood flow and blood volume. With the exception of arteriography, no present test for peripheral circulation actually directly visualizes the blood flow. Particularly in the selection of patients for lumbar sympathectomy, the capacity of peripheral vessels to respond to dilatation is an important criterion. In a recent review of available methods for predetermining the successful response to treatment of peripheral vascular diseases it was concluded that the experience of the physician was superior to any ordinary laboratory tests (Messent and others).1 Radioactive materials have been used in the study of peripheral circulation since 1927 (Blumgart and Yens,2 Smith and Quimby,* Elkin and others,5 Friedell and References 1. References 3 and 4. 2. References 6 and 7. 3. Messent, D.; Steiner, R. E., and Goodwin, J.: Investigation of Obliterative Arterial Disease of Lower Limb , Lancet 2:1324, 1953.Crossref 4. Blumgart, H. L., and Yens, O. C.: Studies in Velocity of the Blood Flow: Method Utilized , J. Clin. Invest. 4:1, 1927.Crossref 5. Smith, B. C., and Quimby, E. H.: Tracer Studies with Radioactive Sodium in Patients with Peripheral Vascular Disease , Science 100:175, 1944.Crossref 6. Smith, B. C., and Quimby, E. H.: Radioactive Sodium in Peripheral Vascular Disease Studies , S. Clin. North America 28:304, 1948. 7. Elkin, D. C.; Cooper, F. W., Jr.; Rohrer, R. H.; Miller, W. B., Jr.; Shea, P. C., and Dennis, E. W.: The Study of Peripheral Vascular Diseases with Radioactive Isotopes , Surg., Gynec. & Obst. 87:1, 1948. 8. Friedell, M. T.; Schaffner, F.; Pickett, W. J., and Hummon, I. F.: Radioactive Isotopes in the Study of Peripheral Vascular Disease: I. Derivation of a Circulatory Index , Arch. Int. Med. 83:608, 1949. 9. Friedell, M. T.; Indeck, W., and Schaffner, F.: Radioactive Isotopes in the Study of Peripheral Vascular Disease: III. Further Studies on the Circulation Index with an Evaluation of the Diagnostic and Therapeutic Value of Priscoline , Arch. Int. Med. 85:667, 1950. 10. Kety, S. S.: The Measurement of Regional Circulation by the Use of Radioactive Sodium , Am. Heart J. 38:321, 1949. 11. Wright, H. P.; Osborn, S. B., and Edmonds, D. G.: Rate of Flow of Venous Blood in Legs Measured with Radioactive Sodium , Lancet 2:767, 1948. 12. Mufson, I.; Quimby, E. H., and Smith, B. C.: Use of Radioactive Sodium as a Guide to Efficacy of Drugs Used in Treatment of Peripheral Vascular System: Preliminary Report , Am. J. Med. 4:73, 1948. 13. Miller, H., and Wilson, G. M.: Measurement of Blood Flow by Local Clearance of Radioactive Sodium , Brit. Heart J. 13:227, 1951. 14. Krieger, H.; Storaasli, J. P.; MacIntyre, W. J.; Holden, W. D., and Friedell, H. L.: The Use of Radioactive Iodinated Human Serum Albumin in Evaluating the Peripheral Circulation , Ann. Surg. 136:357, 1952. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives Surgery American Medical Association

Evaluation of Peripheral Circulation with Radioactive Iodinated Serum Albumin: A Preliminary Report

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Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-6908
DOI
10.1001/archsurg.1955.01270140015002
Publisher site
See Article on Publisher Site

Abstract

Abstract Methods which permit measurement of peripheral blood flow volume should prove valuable in the study of peripheral vascular diseases. A review of the voluminous literature on the subject indicates that most of the present techniques reflect an indirect estimation of the peripheral blood flow and blood volume. With the exception of arteriography, no present test for peripheral circulation actually directly visualizes the blood flow. Particularly in the selection of patients for lumbar sympathectomy, the capacity of peripheral vessels to respond to dilatation is an important criterion. In a recent review of available methods for predetermining the successful response to treatment of peripheral vascular diseases it was concluded that the experience of the physician was superior to any ordinary laboratory tests (Messent and others).1 Radioactive materials have been used in the study of peripheral circulation since 1927 (Blumgart and Yens,2 Smith and Quimby,* Elkin and others,5 Friedell and References 1. References 3 and 4. 2. References 6 and 7. 3. Messent, D.; Steiner, R. E., and Goodwin, J.: Investigation of Obliterative Arterial Disease of Lower Limb , Lancet 2:1324, 1953.Crossref 4. Blumgart, H. L., and Yens, O. C.: Studies in Velocity of the Blood Flow: Method Utilized , J. Clin. Invest. 4:1, 1927.Crossref 5. Smith, B. C., and Quimby, E. H.: Tracer Studies with Radioactive Sodium in Patients with Peripheral Vascular Disease , Science 100:175, 1944.Crossref 6. Smith, B. C., and Quimby, E. H.: Radioactive Sodium in Peripheral Vascular Disease Studies , S. Clin. North America 28:304, 1948. 7. Elkin, D. C.; Cooper, F. W., Jr.; Rohrer, R. H.; Miller, W. B., Jr.; Shea, P. C., and Dennis, E. W.: The Study of Peripheral Vascular Diseases with Radioactive Isotopes , Surg., Gynec. & Obst. 87:1, 1948. 8. Friedell, M. T.; Schaffner, F.; Pickett, W. J., and Hummon, I. F.: Radioactive Isotopes in the Study of Peripheral Vascular Disease: I. Derivation of a Circulatory Index , Arch. Int. Med. 83:608, 1949. 9. Friedell, M. T.; Indeck, W., and Schaffner, F.: Radioactive Isotopes in the Study of Peripheral Vascular Disease: III. Further Studies on the Circulation Index with an Evaluation of the Diagnostic and Therapeutic Value of Priscoline , Arch. Int. Med. 85:667, 1950. 10. Kety, S. S.: The Measurement of Regional Circulation by the Use of Radioactive Sodium , Am. Heart J. 38:321, 1949. 11. Wright, H. P.; Osborn, S. B., and Edmonds, D. G.: Rate of Flow of Venous Blood in Legs Measured with Radioactive Sodium , Lancet 2:767, 1948. 12. Mufson, I.; Quimby, E. H., and Smith, B. C.: Use of Radioactive Sodium as a Guide to Efficacy of Drugs Used in Treatment of Peripheral Vascular System: Preliminary Report , Am. J. Med. 4:73, 1948. 13. Miller, H., and Wilson, G. M.: Measurement of Blood Flow by Local Clearance of Radioactive Sodium , Brit. Heart J. 13:227, 1951. 14. Krieger, H.; Storaasli, J. P.; MacIntyre, W. J.; Holden, W. D., and Friedell, H. L.: The Use of Radioactive Iodinated Human Serum Albumin in Evaluating the Peripheral Circulation , Ann. Surg. 136:357, 1952.

Journal

A.M.A. Archives SurgeryAmerican Medical Association

Published: Aug 1, 1955

References