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EVALUATION OF NEOMYCIN-PHTHALYLSULFATHIAZOLE IN PREPARATION OF THE LARGE BOWEL FOR SURGERY

EVALUATION OF NEOMYCIN-PHTHALYLSULFATHIAZOLE IN PREPARATION OF THE LARGE BOWEL FOR SURGERY Abstract THE NEED for an effective intestinal antiseptic was evidenced as early as 1874, by Billroth1 in his work on intestinal antisepsis. But no significant advance in this direction occurred until Poth2 introduced succinylsulfathiazole as an adjunct in the preparation of the large bowel for surgery. Despite the use of new antibiotics within the past five years, including streptomycin, chlortetracycline (Aureomycin), chloramphenicol, and oxytetracycline (Terramycin), no single agent has proved completely satisfactory for all cases. A variety of unfavorable reactions, including diarrhea, proctitis, pruritus ani, pseudomembranous colitis with fatalities,* and outgrowth of resistant organisms has been noted with the use of certain antibiotics as intestinal antiseptics. For effective use in the preparation of the colon or rectum, Poth5 has set forth the properties of an ideal intestinal antiseptic. It is unlikely that any single antimicrobial drug will be found which fulfills all of these criteria, but it is References 1. References 3 and 4. 2. The material used in this study was supplied by Sharp & Dohme, Inc., Philadelphia. 3. References 9 and 10. 4. Billroth, C. T.: Untersuchungen über die Vegetations formen von Coccobacteria septica: Versuch einer wissenshaftlichen Kritik der vershiedenen Methoden antiseptisher Wundbehandlung , Berlin, G. Riemer, 1874. 5. Poth, E. J.; Knotts, F. L.; Lee, J. T., and Unui, F.: Bacteriostatic Properties of Sulfanilamide and Some Chemotherapeutic Agent Locally Active in the Gastrointestinal Tract , Arch. Surg. 44:187, 1942.Crossref 6. Kleckner, M. S., Jr.; Bargen, J. A., and Baggenstoss, A. H.: Pseudomembranous Enterocolitis: Clinicopathologic Study of Fourteen Cases in Which the Disease Was Not Preceded by an Operation , Gastroenterology 21:212-222, 1952. 7. Reiner, L.; Schlesinger, J. J., and Miller, G. M.: Pseudomembranous Colitis Following Aureomycin and Chloramphenical , A. M. A. Arch. Path. 54:39-67, 1952. 8. Poth, E. J.: Modern Concepts of Intestinal Anti-Sepsis , Am. J. Surg. 18:572-578, 1952. 9. Rowe, R. J.; Spaulding, E. H.; Madajewski, D. S., and Bacon, H. E.: Evaluation of Sulfathalidine and Streptomycin as Adjuncts in Preparing the Large Bowel for Surgery , Surg., Gynec. & Obst. 87:576-582, 1948. 10. Spaulding, E. H.; Madajewski, D. S.; Rowe, R. J., and Bacon, H. E.: The Effect of Orally Administered Streptomycin and Sulfathalidine upon the Bacterial Flora of the Colon , J. Bact. 58:279-289, 1951. 11. Poth, E. J.; Fromm, S. M.; Wise, R. I., and Hsiang, C. M.: Neomycin, a New Intestinal Antiseptic , Texas Rep. Biol. & Med. 33:1099, 1950. 12. Poth, E. J.; Martin, R. G.; Fromm, S. M.; Wise, R. I., and Hsiang, C. M.: A Critical Analysis of Neomycin as an Intestinal Antiseptic , Texas Rep. Biol. & Med. 9:631-644, 1951. 13. Waksman, S. A.: Neomycin, Nature Formation, Isolation, and Practical Application , New Brunswick, N. J., Rutgers University Press, 1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives Surgery American Medical Association

EVALUATION OF NEOMYCIN-PHTHALYLSULFATHIAZOLE IN PREPARATION OF THE LARGE BOWEL FOR SURGERY

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Publisher
American Medical Association
Copyright
Copyright © 1954 American Medical Association. All Rights Reserved.
ISSN
0096-6908
DOI
10.1001/archsurg.1954.01260050346010
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Abstract

Abstract THE NEED for an effective intestinal antiseptic was evidenced as early as 1874, by Billroth1 in his work on intestinal antisepsis. But no significant advance in this direction occurred until Poth2 introduced succinylsulfathiazole as an adjunct in the preparation of the large bowel for surgery. Despite the use of new antibiotics within the past five years, including streptomycin, chlortetracycline (Aureomycin), chloramphenicol, and oxytetracycline (Terramycin), no single agent has proved completely satisfactory for all cases. A variety of unfavorable reactions, including diarrhea, proctitis, pruritus ani, pseudomembranous colitis with fatalities,* and outgrowth of resistant organisms has been noted with the use of certain antibiotics as intestinal antiseptics. For effective use in the preparation of the colon or rectum, Poth5 has set forth the properties of an ideal intestinal antiseptic. It is unlikely that any single antimicrobial drug will be found which fulfills all of these criteria, but it is References 1. References 3 and 4. 2. The material used in this study was supplied by Sharp & Dohme, Inc., Philadelphia. 3. References 9 and 10. 4. Billroth, C. T.: Untersuchungen über die Vegetations formen von Coccobacteria septica: Versuch einer wissenshaftlichen Kritik der vershiedenen Methoden antiseptisher Wundbehandlung , Berlin, G. Riemer, 1874. 5. Poth, E. J.; Knotts, F. L.; Lee, J. T., and Unui, F.: Bacteriostatic Properties of Sulfanilamide and Some Chemotherapeutic Agent Locally Active in the Gastrointestinal Tract , Arch. Surg. 44:187, 1942.Crossref 6. Kleckner, M. S., Jr.; Bargen, J. A., and Baggenstoss, A. H.: Pseudomembranous Enterocolitis: Clinicopathologic Study of Fourteen Cases in Which the Disease Was Not Preceded by an Operation , Gastroenterology 21:212-222, 1952. 7. Reiner, L.; Schlesinger, J. J., and Miller, G. M.: Pseudomembranous Colitis Following Aureomycin and Chloramphenical , A. M. A. Arch. Path. 54:39-67, 1952. 8. Poth, E. J.: Modern Concepts of Intestinal Anti-Sepsis , Am. J. Surg. 18:572-578, 1952. 9. Rowe, R. J.; Spaulding, E. H.; Madajewski, D. S., and Bacon, H. E.: Evaluation of Sulfathalidine and Streptomycin as Adjuncts in Preparing the Large Bowel for Surgery , Surg., Gynec. & Obst. 87:576-582, 1948. 10. Spaulding, E. H.; Madajewski, D. S.; Rowe, R. J., and Bacon, H. E.: The Effect of Orally Administered Streptomycin and Sulfathalidine upon the Bacterial Flora of the Colon , J. Bact. 58:279-289, 1951. 11. Poth, E. J.; Fromm, S. M.; Wise, R. I., and Hsiang, C. M.: Neomycin, a New Intestinal Antiseptic , Texas Rep. Biol. & Med. 33:1099, 1950. 12. Poth, E. J.; Martin, R. G.; Fromm, S. M.; Wise, R. I., and Hsiang, C. M.: A Critical Analysis of Neomycin as an Intestinal Antiseptic , Texas Rep. Biol. & Med. 9:631-644, 1951. 13. Waksman, S. A.: Neomycin, Nature Formation, Isolation, and Practical Application , New Brunswick, N. J., Rutgers University Press, 1953.

Journal

A.M.A. Archives SurgeryAmerican Medical Association

Published: Mar 1, 1954

References