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EVALUATION OF A NEW DRUG FOR TOPICAL THERAPY OF TINEA CAPITIS

EVALUATION OF A NEW DRUG FOR TOPICAL THERAPY OF TINEA CAPITIS Abstract THE INCREASE in the incidence of tinea capitis of the anthropophilic type, which has often assumed epidemic proportions during the past several years, has clearly demonstrated the need for a simplified form of effective treatment. Many therapeutic approaches have been abandoned as unsatisfactory, and others have met with varying degrees of success. For example, the use of trichophytin injections produced equivocal results and was discarded.1 Similarly, the topical administration of hormones proved of only dubious value.2 The proper application of trimethyl cetyl ammonium pentachlorphenate (T. C. A. P.)3 required diligent care for several hours daily, and the use of this product was therefore relinquished as impracticable. While fatty-acid compounds have merits in the treatment of mycoses of the glabrous skin, they are ineffectual against tinea capitis. Salicylanilide ointment is attended by better results, but it still leaves much to be desired. Against this background, we welcomed the References 1. Lewis, G. M., and Hopper, M. E.: An Introduction to Medical Mycology , ed. 2, Chicago, The Year Book Publishers, Inc., 1943. 2. Poth, D. O., and Kaliski, S. R.: Estrogen Therapy of Tinea Capitis: Preliminary Report , Arch. Dermat. & Syph. 45:121-128 ( (Jan.) ) 1942. 3. Lewis, G. M.: Hopper, M. E., and Reiss, F.: Ringworm of Scalp: Clinical Data on Recent Cases; Experiences with Local Endocrine Therapy , J. A. M. A. 132:62-65 ( (Sept. 14) ) 1946. 4. McKee, G. M.; Herrmann, F., and Karp, F. L.: New Treatment for Anthropophilic Tinea Tonsurans (Microsporon Audouini): Preliminary Report , J. Invest. Dermat. 7:43-52 ( (Feb.) ) 1946. 5. The materials used in this study were supplied by Hoffman-LaRoche, Inc., Nutley, N. J., through the cooperation of Dr. Leo A. Pirk. They were furnished first under the code number Ro2-2453 and later under the name of asterol® dihydrochloride. Originally, an ointment and tincture containing 2% of the active agent were employed. As the study progressed this was increased to 5%. 6. Grunberg, E.; Soo-Hoo, G.; Titsworth, E.; Ressetar, D., and Schnitzer, R. J.: Mycological Studies with a New Benzothiazole with Specific Activity Against Dermatophytes , Tr. New York Acad. Sc. 13:22-27 ( (Nov.) ) 1950. 7. Stritzler, C.; Fishman, I. M., and Laurens, S.: Treatment of Superficial Fungus Infections with a New Antifungal Agent , Tr. New York Acad. Sc. 13:31-37 ( (Nov.) ) 1950. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology & Syphilology American Medical Association

EVALUATION OF A NEW DRUG FOR TOPICAL THERAPY OF TINEA CAPITIS

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Publisher
American Medical Association
Copyright
Copyright © 1951 American Medical Association. All Rights Reserved.
ISSN
0096-5979
DOI
10.1001/archderm.1951.01570100061011
Publisher site
See Article on Publisher Site

Abstract

Abstract THE INCREASE in the incidence of tinea capitis of the anthropophilic type, which has often assumed epidemic proportions during the past several years, has clearly demonstrated the need for a simplified form of effective treatment. Many therapeutic approaches have been abandoned as unsatisfactory, and others have met with varying degrees of success. For example, the use of trichophytin injections produced equivocal results and was discarded.1 Similarly, the topical administration of hormones proved of only dubious value.2 The proper application of trimethyl cetyl ammonium pentachlorphenate (T. C. A. P.)3 required diligent care for several hours daily, and the use of this product was therefore relinquished as impracticable. While fatty-acid compounds have merits in the treatment of mycoses of the glabrous skin, they are ineffectual against tinea capitis. Salicylanilide ointment is attended by better results, but it still leaves much to be desired. Against this background, we welcomed the References 1. Lewis, G. M., and Hopper, M. E.: An Introduction to Medical Mycology , ed. 2, Chicago, The Year Book Publishers, Inc., 1943. 2. Poth, D. O., and Kaliski, S. R.: Estrogen Therapy of Tinea Capitis: Preliminary Report , Arch. Dermat. & Syph. 45:121-128 ( (Jan.) ) 1942. 3. Lewis, G. M.: Hopper, M. E., and Reiss, F.: Ringworm of Scalp: Clinical Data on Recent Cases; Experiences with Local Endocrine Therapy , J. A. M. A. 132:62-65 ( (Sept. 14) ) 1946. 4. McKee, G. M.; Herrmann, F., and Karp, F. L.: New Treatment for Anthropophilic Tinea Tonsurans (Microsporon Audouini): Preliminary Report , J. Invest. Dermat. 7:43-52 ( (Feb.) ) 1946. 5. The materials used in this study were supplied by Hoffman-LaRoche, Inc., Nutley, N. J., through the cooperation of Dr. Leo A. Pirk. They were furnished first under the code number Ro2-2453 and later under the name of asterol® dihydrochloride. Originally, an ointment and tincture containing 2% of the active agent were employed. As the study progressed this was increased to 5%. 6. Grunberg, E.; Soo-Hoo, G.; Titsworth, E.; Ressetar, D., and Schnitzer, R. J.: Mycological Studies with a New Benzothiazole with Specific Activity Against Dermatophytes , Tr. New York Acad. Sc. 13:22-27 ( (Nov.) ) 1950. 7. Stritzler, C.; Fishman, I. M., and Laurens, S.: Treatment of Superficial Fungus Infections with a New Antifungal Agent , Tr. New York Acad. Sc. 13:31-37 ( (Nov.) ) 1950.

Journal

A.M.A. Archives of Dermatology & SyphilologyAmerican Medical Association

Published: Oct 1, 1951

References