Abstract Recently observations on the urinary excretion of estrin in a series of patients with acne were reported by one of us (T. R.) in collaboration with Kurzrok.1 There was complete absence of the hormone in twenty-seven of thirty-four patients in this series, the specimens of urine being examined during various phases of the menstrual cycle. Kurzrok's studies2 indicate that the excretion is fairly constant throughout the cycle. The work of Frank and his associates,3 on the other hand, tends to show that in the normal fertile menstruating woman the concentration of estrogenic substance in both the blood and the urine undergoes regular cyclic variations and also that the renal permeability of these substances varies in the individual.4 In view of these possibilities, therefore, it seemed worth while to repeat these observations, estimating premenstrual values for estrogenic substance in the blood in patients with References 1. Rosenthal, T., and Kurzrok, R.: Proc. Soc. Exper. Biol. & Med. 30:1150, 1933. 2. Kurzrok, R.: New York State J. Med. 32:1287, 1932. 3. Frank, R. T.: The Female Sex Hormone , Springfield, Ill., Charles C. Thomas, Publisher, 1929. 4. Frank, R. T., and Goldberger, M. A.: Female Sex Hormone; Utilization of Hormone in Normal Woman; Effect of Abnormal Kidney Permeability in Production of Amenorrhea and Sterility , J. A. M. A. 94:1197 ( (April 19) ) 1930. 5. Frank, R. T., and Goldberger, M. A.: Clinical Data Obtained with Female Sex Hormone Blood Test , J. A. M. A. 90:106 ( (Jan. 14) ) 1928. 6. Neustaedter, T.: Unpublished observations. 7. Mazer, C., and Goldstein, L.: Clinical Endocrinology of the Female , Philadelphia, W. B. Saunders Company, 1932, p. 165. 8. Hollander, L.: Rôle of the Endocrine Glands in Etiology and Treatment of Acne , Arch. Dermat. & Syph. 3:593 ( (May) ) 1921. 9. Schamberg, J. F.: Research Problems in Dermatology , Arch. Dermat. & Syph. 4:293 ( (Sept. 3) ) 1921. 10. Darier, J.: Précis de dermatologie , Paris, Masson & Cie, 1928, p. 508. 11. Bloch, B.: Brit. J. Dermat. 43:61, 1931. 12. Eideken, quoted by Mazer and Goldstein.7 13. Kurzrok, R., and Ratner, S.: Am. J. Obst. & Gynec. 23:689, 1932.
Archives of Dermatology and Syphilology – American Medical Association
Published: Oct 1, 1935