Abstract In another communication1 observations were reported on seven patients with hemophilia in whom no demonstrable improvement in the coagulation of the blood or in the clinical state resulted from the oral and parenteral administration of various ovarian and estrogenic substances. The failure to enhance the coagulability of the blood in hemophilia by the administration of an estrogenic substance has been noted by Blaylock,2 who observed a slight increase in the coagulation time of the blood of his patient with hemophilia one week after starting daily subcutaneous injections of an "ovarian preparation obtained from the fetal fluid of cattle." Brown and Albright3 similarly observed no beneficial effect in one patient with hemophilia who was given injections of large amounts of estrogenic substance over a period of three days. More recently, Brem and Leopold4 have reported negative observations on the coagulation time and clinical state of a patient References 1. Stetson, R. P.; Forkner, C. E.; Chew, W. B., and Rich, M. L.: The Negative Effect of Prolonged Administration of Ovarian Substance in Hemophilia , J. A. M. A. 102:1122 ( (April 7) ) 1934.Crossref 2. Blaylock, A.: Amputation of Arm of Patient with Hemophilia , J. A. M. A. 99:1777 ( (Nov. 19) ) 1932.Crossref 3. Brown, R. L., and Albright, F.: Estrin Therapy in a Case of Hemophilia , New England J. M. 209:630 ( (Sept. 28) ) 1933.Crossref 4. Brem, J., and Leopold, J. S.: Ovarian Therapy: Relationship of the Female Sex Hormone to Hemophilia , J. A. M. A. 102:200 ( (Jan. 23) ) 1934.Crossref 5. Birch, C. L.: (a) Hemophilia , Proc. Soc. Exper. Biol. & Med. 28:752 ( (April) ) 1931 6. Hemophilia , J. A. M. A. 99:1566 ( (Nov. 5) ) 1932. 7. Foord, A. G., and Dysart, B. R.: Treatment of Hemophilia by an Ovarian Extract by Birch's Method , J. A. M. A. 98:1444 ( (April 23) ) 1932. 8. Kimm, H. T., and Van Allen, C. M.: Hemophilia: Prevention and Treatment of Bleeding with Ovarian Extract , J. A. M. A. 99:991 ( (Sept. 17) ) 1932. 9. White, C. E.: Treatment of Hemophilia with Theelin , J. Oklahoma M. A. 25:304 ( (July) ) 1932. 10. Hirst, J. C.: The Influence of Female Sex Hormones upon Blood Coagulation of the Newborn , Am. J. Obst. & Gynec. 26:217 ( (Aug.) ) 1933. 11. Spoto, J. S.: Treatment of Hemophilia with Ovarian Extract , J. Florida M. A. 20:9 ( (July) ) 1933. 12. Hynek, K.: Nouvelles considérations sur l'hémophilie , Ann. de méd. 14:122 ( (Aug.) ) 1923. 13. Neihans, P.: Treatment of Hemophilia , Schweiz. med. Wchnschr. 60:18 ( (Jan. 4) ) 1930. 14. Birch, C. L.: Hemophilia and the Female Sex Hormone , J. A. M. A. 97:244 ( (July 25) ) 1931. 15. Mazer, C., and Goldstein, L.: Clinical Endocrinology of the Female , Philadelphia, W. B. Saunders Company, 1933. 16. Smith, G. V., and Smith, O. W.: Studies on the Urinary Excretion of Estrin, with Especial Reference to the Effect of the Luteinizing Hormone and Progestin , Am. J. Physiol. 98:578 ( (Nov.) ) 1931. 17. Smith, G. V., and Rock, J.: Dysfunctional Uterine Bleeding , Surg., Gynec. & Obst. 57:100 ( (July) ) 1933. 18. Frank, R. T.: Rôle of the Female Sex Hormone , J. A. M. A. 97:1852 ( (Dec. 19) ) 1931. 19. The numbers correspond to those assigned the patients in our previous report.1 20. Wiedemer, quoted by Mills, C. A.: Hemophilia , J. Lab. & Clin. Med. 17: 932 ( (June) ) 1932.
Archives of Internal Medicine – American Medical Association
Published: Mar 1, 1935
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