Abstract The daily requirement of the normal person for ascorbic acid is difficult to determine accurately, and the minimal and optimal quantities needed remain a subject of some controversy at the present time. It is generally accepted, however, that the deficiency of vitamin C which is of so frequent occurrence in infections and in conditions associated with heightened metabolism is due to an increased need for ascorbic acid by the body and not merely to a deficient supply in the diet. It seemed to us that it should be possible to compare grossly the requirements in health and in disease without detailed metabolic experiments. The object of this study was to evolve a method by which the ascorbic acid requirements of ambulatory patients attending an outpatient clinic could be estimated. Our interest in the problem was stimulated by finding a vitamin C deficiency to be extremely frequent in persons with bronchial References 1. Supplied by Merck & Co., Inc. 2. Bessey, O.: Vitamin C: Methods of Assay and Dietary Sources , J. A. M. A. 111:1290 ( (Oct. 1) ) 1938.Crossref 3. Smith, S. L.: Human Requirements of Vitamin C , J. A. M. A. 111: 1753 ( (Nov. 5) ) 1938.Crossref 4. Ralli, E. P.; Friedman, G. J., and Sherry, S.: The Vitamin C Requirement of Man, Estimated After Prolonged Studies of the Plasma Concentration and Daily Excretion of Vitamin C in Three Adults on Controlled Diets , J. Clin. Investigation 18:708, 1939.Crossref 5. Belser, W. B.; Hauck, H. M., and Storvick, C. A.: A Study of the Ascorbic Acid Intake Required to Maintain Tissue Saturation in Normal Adults , J. Nutrition 17:513, 1939. 6. Farmer, C. J., and Abt, A. F.: Determination of Reduced Ascorbic Acid in Small Amounts of Blood , Proc. Soc. Exper. Biol. & Med. 34:146, 1936. 7. Wright, I. S., and MacLenathen, E.: Vitamin C Saturation: Kidney Retention After an Intravenous Test Dose of Ascorbic Acid , Proc. Soc. Exper. Biol. & Med. 38:55, 1938. 8. Van Eekelen, M.: On the Amount of Ascorbic Acid in Blood and Urine: The Daily Human Requirements for Ascorbic Acid , J. Biochem. 30: 2291, 1936. 9. Faulkner, J. M., and Taylor, F. H. L.: Observations on the Renal Threshold for Ascorbic Acid in Urine , J. Clin. Investigation 17:69, 1938. 10. Hamel, P.: Ueber die Vitamin C-Bilanz des Menschen: II. Belastungsversuche zur Bestimmung des tälichen Verbrauches und des Sättigungsdefizits , Klin. Wchnschr. 16:1105, 1937. 11. Belser, Hauck and Storvick.
Archives of Internal Medicine – American Medical Association
Published: Mar 1, 1941
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