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Erythrocyte Polyamine Determinations in Patients With Head and Neck Cancer

Erythrocyte Polyamine Determinations in Patients With Head and Neck Cancer Abstract • Erythrocyte polyamine levels were measured in the blood from 29 untreated patients whose conditions were diagnosed as head and neck cancer. Only nine (31%) of these patients had elevations of erythrocyte spermidine and/or spermine levels above the reference ranges determined for normal persons. However, a positive correlation was observed between the erythrocyte spermidine levels and the clinical tumor stage. Serial erythrocyte polyamine determinations were performed on the blood from 12 of these patients before and after either surgical or radiation therapy. In 11 of the cases, the erythrocyte spermidine levels decreased after tumor therapy regardless of whether there was prior elevation above the reference range. The erythrocyte spermine levels in these patients were more variable in their response to tumor treatment. Therefore, although erythrocyte polyamine levels were only slightly to moderately elevated in response to the small tumors characteristic of the head and neck, the measurement of erythrocyte spermidine, potentially, may offer a simple and effective means of monitoring the course of therapy used in patients with head and neck cancer. (Arch Otolaryngol 1981;107:752-754) References 1. Cohen SS: Introduction to the Polyamines . Englewood Cliffs, NJ, Prentice-Hall Inc, 1971. 2. Tabor H, Tabor CW: Spermidine, spermine, and related amines . Pharmacol Rev 1964;16:245-300. 3. Bachrach U: Function of Naturally Occurring Polyamines . New York, Academic Press Inc, 1973. 4. Raina A, Jänne J: Physiology of the natural polyamines putrescine, spermidine, and spermine . Med Biol 1975;53:121-147. 5. Russell DH, Levy CC, Schimpff SC, et al: Urinary polyamines in cancer patients . Cancer Res 1971;31:1555-1558. 6. Fujita K, Nagatsu T, Maruta K, et al: Urinary putrescine, spermidine, and spermine in human blood and solid cancers and in an experimental gastric tumor of rats . Cancer Res 1976;36:1320-1324. 7. Sanford EJ, Drago JR, Rohner TJ, et al: Preliminary evaluation of urinary polyamines in the diagnosis of genitourinary tract malignancy . J Urol 1975;113:218-221. 8. Fair WR, Wehner N, Brorsson U: Urinary polyamine levels in the diagnosis of carcinoma of the prostate . J Urol 1975;114:88-92. 9. Tormey DC, Waalkes TP, Ahmann D, et al: Biologic markers in breast carcinoma: I. Incidence of abnormalities of CEA, HCG, three polyamines and three minor nucleotides . Cancer 1975;35:1095-1100.Crossref 10. Tsuji M, Nakajima T, Sano I: Putrescine, spermidine, N-acetyl-spermidline and spermine in the urine of patients with leukaemias and tumors . Clin Chim Acta 1975;59:161-167.Crossref 11. Waalkes TP, Gehrke CW, Tormey DC, et al: Urinary excretion of polyamines by patients with advanced malignancy . Cancer Chemother Rep 1975;59:1103-1116. 12. Lipton A, Sheehan L, Mortel R, et al: Urinary polyamine levels in patients with localized malignancy . Cancer 1976;38:1344-1347.Crossref 13. Lipton A, Sheehan LM, Kessler GF Jr: Urinary polyamine levels in human cancer . Cancer 1975;35:464-468.Crossref 14. Russell DH: Clinical relevance of polyamines as biochemical markers of tumor kinetics . Clin Chem 1977;23:22-27. 15. Jänne J, Poso H, Raina A: Polyamines in rapid growth and cancer . Biochim Biophys Acta 1978;473:241-293. 16. Marton LJ, Heby O, Levin VA, et al: The relationship of polyamines in cerebrospinal fluid to the presence of central nervous system tumors . Cancer Res 1976;36:973-977. 17. Shipe JR, Savory J: High performance liquid chromatographic separation and fluorescence detection of polyamines in plasma and erythrocytes . Ann Clin Lab Sci 1980;10:128-136. 18. Cooper KD, Shukla JB, Rennert OM: Polyamine distribution in cellular compartments of blood and in aging erythrocytes . Clin Chim Acta 1976;73:71-88.Crossref 19. Savory J, Shipe JR, Wills MR: Polyamines in blood-cells as cancer markers . Lancet 1979;2:1136-1137.Crossref 20. Takami H, Romsdahl MM, Nishioka K: Polyamines in blood-cells as a cancer marker . Lancet 1979;2:912.Crossref 21. Cooper KD, Shukla JB, Rennert OM: Polyamine compartmentalization in various human disease states . Clin Chim Acta 1978;82:1-7.Crossref 22. Saeki Y, Uehara N, Shirakawa S: Sensitive fluorometric method for the determination of putrescine, spermidine and spermine by high-performance liquid chromatography and its application to human blood . J Chromatogr 1978;145:221-229.Crossref 23. Shipe JR, Savory J, Wills MR, et al: Erythrocyte polyamine levels in rats with H4IIE hepatomas before and after radiation therapy . Res Commun Chem Pathol Pharmacol 1980;28:329-342. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Erythrocyte Polyamine Determinations in Patients With Head and Neck Cancer

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Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1981.00790480028007
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Abstract

Abstract • Erythrocyte polyamine levels were measured in the blood from 29 untreated patients whose conditions were diagnosed as head and neck cancer. Only nine (31%) of these patients had elevations of erythrocyte spermidine and/or spermine levels above the reference ranges determined for normal persons. However, a positive correlation was observed between the erythrocyte spermidine levels and the clinical tumor stage. Serial erythrocyte polyamine determinations were performed on the blood from 12 of these patients before and after either surgical or radiation therapy. In 11 of the cases, the erythrocyte spermidine levels decreased after tumor therapy regardless of whether there was prior elevation above the reference range. The erythrocyte spermine levels in these patients were more variable in their response to tumor treatment. Therefore, although erythrocyte polyamine levels were only slightly to moderately elevated in response to the small tumors characteristic of the head and neck, the measurement of erythrocyte spermidine, potentially, may offer a simple and effective means of monitoring the course of therapy used in patients with head and neck cancer. (Arch Otolaryngol 1981;107:752-754) References 1. Cohen SS: Introduction to the Polyamines . Englewood Cliffs, NJ, Prentice-Hall Inc, 1971. 2. Tabor H, Tabor CW: Spermidine, spermine, and related amines . Pharmacol Rev 1964;16:245-300. 3. Bachrach U: Function of Naturally Occurring Polyamines . New York, Academic Press Inc, 1973. 4. Raina A, Jänne J: Physiology of the natural polyamines putrescine, spermidine, and spermine . Med Biol 1975;53:121-147. 5. Russell DH, Levy CC, Schimpff SC, et al: Urinary polyamines in cancer patients . Cancer Res 1971;31:1555-1558. 6. Fujita K, Nagatsu T, Maruta K, et al: Urinary putrescine, spermidine, and spermine in human blood and solid cancers and in an experimental gastric tumor of rats . Cancer Res 1976;36:1320-1324. 7. Sanford EJ, Drago JR, Rohner TJ, et al: Preliminary evaluation of urinary polyamines in the diagnosis of genitourinary tract malignancy . J Urol 1975;113:218-221. 8. Fair WR, Wehner N, Brorsson U: Urinary polyamine levels in the diagnosis of carcinoma of the prostate . J Urol 1975;114:88-92. 9. Tormey DC, Waalkes TP, Ahmann D, et al: Biologic markers in breast carcinoma: I. Incidence of abnormalities of CEA, HCG, three polyamines and three minor nucleotides . Cancer 1975;35:1095-1100.Crossref 10. Tsuji M, Nakajima T, Sano I: Putrescine, spermidine, N-acetyl-spermidline and spermine in the urine of patients with leukaemias and tumors . Clin Chim Acta 1975;59:161-167.Crossref 11. Waalkes TP, Gehrke CW, Tormey DC, et al: Urinary excretion of polyamines by patients with advanced malignancy . Cancer Chemother Rep 1975;59:1103-1116. 12. Lipton A, Sheehan L, Mortel R, et al: Urinary polyamine levels in patients with localized malignancy . Cancer 1976;38:1344-1347.Crossref 13. Lipton A, Sheehan LM, Kessler GF Jr: Urinary polyamine levels in human cancer . Cancer 1975;35:464-468.Crossref 14. Russell DH: Clinical relevance of polyamines as biochemical markers of tumor kinetics . Clin Chem 1977;23:22-27. 15. Jänne J, Poso H, Raina A: Polyamines in rapid growth and cancer . Biochim Biophys Acta 1978;473:241-293. 16. Marton LJ, Heby O, Levin VA, et al: The relationship of polyamines in cerebrospinal fluid to the presence of central nervous system tumors . Cancer Res 1976;36:973-977. 17. Shipe JR, Savory J: High performance liquid chromatographic separation and fluorescence detection of polyamines in plasma and erythrocytes . Ann Clin Lab Sci 1980;10:128-136. 18. Cooper KD, Shukla JB, Rennert OM: Polyamine distribution in cellular compartments of blood and in aging erythrocytes . Clin Chim Acta 1976;73:71-88.Crossref 19. Savory J, Shipe JR, Wills MR: Polyamines in blood-cells as cancer markers . Lancet 1979;2:1136-1137.Crossref 20. Takami H, Romsdahl MM, Nishioka K: Polyamines in blood-cells as a cancer marker . Lancet 1979;2:912.Crossref 21. Cooper KD, Shukla JB, Rennert OM: Polyamine compartmentalization in various human disease states . Clin Chim Acta 1978;82:1-7.Crossref 22. Saeki Y, Uehara N, Shirakawa S: Sensitive fluorometric method for the determination of putrescine, spermidine and spermine by high-performance liquid chromatography and its application to human blood . J Chromatogr 1978;145:221-229.Crossref 23. Shipe JR, Savory J, Wills MR, et al: Erythrocyte polyamine levels in rats with H4IIE hepatomas before and after radiation therapy . Res Commun Chem Pathol Pharmacol 1980;28:329-342.

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Dec 1, 1981

References