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Erythrocyte Metabolism in Muscular Dystrophy

Erythrocyte Metabolism in Muscular Dystrophy Abstract • Erythrocytes from patients with Duchenne's and myotonic muscular dystrophies contained more adenosine triphosphate (ATP) and produced more lactate than did normal erythrocytes in incubation studies conducted in vitro at an initial pH of 7.4. Since the same results were obtained in two different genetic dystrophies, these metabolic variations appear to be secondary to the primary changes occurring in these diseases. Following ouabain treatment, ATP content increased and lactate production decreased in erythrocytes from both dystrophies. This result differs from one reported earlier in experiments conducted at alkaline pH. References 1. Rowland LP: Pathogenesis of muscular dystrophies . Arch Neurol 33:315-321, 1976.Crossref 2. Thomson WHS, Sweetin JC, Hamilton IJD: ATP and muscle efflux after physical exertion . Clin Chim Acta 59:241-245, 1975.Crossref 3. Zierler K: Muscle membrane as a dynamic structure and its permeability to aldolase . Ann NY Acad Sci 75:227-235, 1958.Crossref 4. Bosia A, Pescarmona GP, Arese P: Red cell glycolysis in the myodystrophic child . Eur J Clin Invest 1:413-420, 1971.Crossref 5. Lamprecht W, Trautschold I: Adenosine 5-triphosphate determination with hexokinase and glucose 6-phosphate dehydrogenase , in Bergmeyer HU (ed): Methods of Enzymatic Analysis . New York, Academic Press Inc, 1965, pp 543-551. 6. Hohorst HJ, Kreutz FH, Bucher T: Ueber metabolitgehalte und metabolitkonzentrationen in der leber der ratte . Biochem Z 332:18-46, 1959. 7. Fiske CH, Subbarow Y: The colorimetric determination of phosphorus . J Biol Chem 66:375-400, 1925. 8. Card RT, Brain MC: The "anemia" of child-hood . N Engl J Med 288:388-392, 1973.Crossref 9. Whittam R, Ager ME: The connection between active cation transport and metabolism in erythrocytes . Biochem J 97:214-227, 1965. 10. Rapoport S: Control mechanisms of red cell glycolysis , in Greenwalt TJ, Jamieson GA (eds): The Human Red Cell in Vitro . New York, Grune & Stratton Inc, 1974, pp 153-178. 11. Minakami S, Yoshikawa H: Inorganic phosphate and erythrocyte glycolysis . Biochim Biophys Acta 99:175-178, 1965.Crossref 12. Brown HD, Chattpadhyay SK, Patel AB: Erythrocyte abnormality in human myopathy . Science 157:1577-1578, 1967.Crossref 13. Sha'afi RI, Rodan SB, Hintz RL, et al: Abnormalities in membrane microviscosity and ion transport in genetic muscular dystrophy . Nature 254:525-526, 1975.Crossref 14. Hull KL, Roses AD: Stoichiometry of sodium and potassium transport in erythrocytes from patients with myotonic muscular dystrophy . J Physiol 254:169-181, 1976. 15. Duhm J, Gerlach E: Metabolism and function of 2,3-diphosphoglycerate in red blood cells , in Greenwalt TJ, Jamieson GA (eds): The Human Red Cell in Vitro . New York, Grune & Stratton Inc, 1974, pp 111-148. 16. Gerlach E, Deuticke B, Duhm J: Phosphatpermeabilitat und phosphatstoffwechsel menschlicher erythrocyten und moglichkeiten ihrer experimentallen beeinflussung . Pfluegers Arch 280:243-274, 1965.Crossref 17. Galder BE, Omachi A: Phosphate release from human erythrocytes . Biochim Biophys Acta 163:30-36, 1968.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Erythrocyte Metabolism in Muscular Dystrophy

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Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1978.00500330040008
Publisher site
See Article on Publisher Site

Abstract

Abstract • Erythrocytes from patients with Duchenne's and myotonic muscular dystrophies contained more adenosine triphosphate (ATP) and produced more lactate than did normal erythrocytes in incubation studies conducted in vitro at an initial pH of 7.4. Since the same results were obtained in two different genetic dystrophies, these metabolic variations appear to be secondary to the primary changes occurring in these diseases. Following ouabain treatment, ATP content increased and lactate production decreased in erythrocytes from both dystrophies. This result differs from one reported earlier in experiments conducted at alkaline pH. References 1. Rowland LP: Pathogenesis of muscular dystrophies . Arch Neurol 33:315-321, 1976.Crossref 2. Thomson WHS, Sweetin JC, Hamilton IJD: ATP and muscle efflux after physical exertion . Clin Chim Acta 59:241-245, 1975.Crossref 3. Zierler K: Muscle membrane as a dynamic structure and its permeability to aldolase . Ann NY Acad Sci 75:227-235, 1958.Crossref 4. Bosia A, Pescarmona GP, Arese P: Red cell glycolysis in the myodystrophic child . Eur J Clin Invest 1:413-420, 1971.Crossref 5. Lamprecht W, Trautschold I: Adenosine 5-triphosphate determination with hexokinase and glucose 6-phosphate dehydrogenase , in Bergmeyer HU (ed): Methods of Enzymatic Analysis . New York, Academic Press Inc, 1965, pp 543-551. 6. Hohorst HJ, Kreutz FH, Bucher T: Ueber metabolitgehalte und metabolitkonzentrationen in der leber der ratte . Biochem Z 332:18-46, 1959. 7. Fiske CH, Subbarow Y: The colorimetric determination of phosphorus . J Biol Chem 66:375-400, 1925. 8. Card RT, Brain MC: The "anemia" of child-hood . N Engl J Med 288:388-392, 1973.Crossref 9. Whittam R, Ager ME: The connection between active cation transport and metabolism in erythrocytes . Biochem J 97:214-227, 1965. 10. Rapoport S: Control mechanisms of red cell glycolysis , in Greenwalt TJ, Jamieson GA (eds): The Human Red Cell in Vitro . New York, Grune & Stratton Inc, 1974, pp 153-178. 11. Minakami S, Yoshikawa H: Inorganic phosphate and erythrocyte glycolysis . Biochim Biophys Acta 99:175-178, 1965.Crossref 12. Brown HD, Chattpadhyay SK, Patel AB: Erythrocyte abnormality in human myopathy . Science 157:1577-1578, 1967.Crossref 13. Sha'afi RI, Rodan SB, Hintz RL, et al: Abnormalities in membrane microviscosity and ion transport in genetic muscular dystrophy . Nature 254:525-526, 1975.Crossref 14. Hull KL, Roses AD: Stoichiometry of sodium and potassium transport in erythrocytes from patients with myotonic muscular dystrophy . J Physiol 254:169-181, 1976. 15. Duhm J, Gerlach E: Metabolism and function of 2,3-diphosphoglycerate in red blood cells , in Greenwalt TJ, Jamieson GA (eds): The Human Red Cell in Vitro . New York, Grune & Stratton Inc, 1974, pp 111-148. 16. Gerlach E, Deuticke B, Duhm J: Phosphatpermeabilitat und phosphatstoffwechsel menschlicher erythrocyten und moglichkeiten ihrer experimentallen beeinflussung . Pfluegers Arch 280:243-274, 1965.Crossref 17. Galder BE, Omachi A: Phosphate release from human erythrocytes . Biochim Biophys Acta 163:30-36, 1968.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Sep 1, 1978

References