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ERYTHROBLASTIC ANEMIA OF COOLEY (FAMILIAL ERYTHROBLASTIC ANEMIA) IN AN INDIAN BOY

ERYTHROBLASTIC ANEMIA OF COOLEY (FAMILIAL ERYTHROBLASTIC ANEMIA) IN AN INDIAN BOY From the ill defined group of conditions known as von Jaksch's anemia, Cooley1 in 1927 separated a type of anemia which occurred in children which he regarded as a clinical entity and which presented characteristic clinical, roentgenologic and microscopic features. He reported that clinically children with this disease exhibited splenomegaly, muddy, yellowish discoloration of the skin and mongoloid facies, due to abnormal prominence of the malar bones. The patients were invariably of Greek, Italian or Syrian stock. Roentgenologically, osseous dystrophy, with thickening and sponginess of the bones, was a characteristic feature; microscopically, there was evidence of hemolytic (hypochromic) anemia, with an unusually large number of nucleated red cells in the blood. Cooley stressed the ancestry of these children, and it came to be believed that this type of anemia was almost exclusively confined to children of Mediterranean stock, so much so that one of the synonyms for familial erythroblastic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

ERYTHROBLASTIC ANEMIA OF COOLEY (FAMILIAL ERYTHROBLASTIC ANEMIA) IN AN INDIAN BOY

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Publisher
American Medical Association
Copyright
Copyright © 1944 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1944.02020040046007
Publisher site
See Article on Publisher Site

Abstract

From the ill defined group of conditions known as von Jaksch's anemia, Cooley1 in 1927 separated a type of anemia which occurred in children which he regarded as a clinical entity and which presented characteristic clinical, roentgenologic and microscopic features. He reported that clinically children with this disease exhibited splenomegaly, muddy, yellowish discoloration of the skin and mongoloid facies, due to abnormal prominence of the malar bones. The patients were invariably of Greek, Italian or Syrian stock. Roentgenologically, osseous dystrophy, with thickening and sponginess of the bones, was a characteristic feature; microscopically, there was evidence of hemolytic (hypochromic) anemia, with an unusually large number of nucleated red cells in the blood. Cooley stressed the ancestry of these children, and it came to be believed that this type of anemia was almost exclusively confined to children of Mediterranean stock, so much so that one of the synonyms for familial erythroblastic

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Apr 1, 1944

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