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Eruptive Neurofibromatosis Associated With Anorexia Nervosa

Eruptive Neurofibromatosis Associated With Anorexia Nervosa Abstract Neurofibromatosis (Recklinghausen's disease) is a well-recognized syndrome transmitted by an autosomal dominant gene. The cutaneous and internal manifestations of the disease have been well known for almost 100 years, but little is known about its pathogenesis. Eruptive neurofibromatosis has previously been reported in association with puberty and pregnancy, suggesting that hormones or growth factors may modulate tumor growth.1,2 We report herein the development of eruptive neurofibromatosis in association with anorexia nervosa. Report of a Case An 18-year-old woman with known neurofibromatosis and anorexia nervosa was seen in April 1981 with a two- to three-week history of the appearance of several hundred papules on her trunk and extremities. She had been previously diagnosed as having neurofibromatosis at 2 years of age, based on the presence of multiple café au lait spots on the trunk and extremities, defective development of the orbital bones, and neurofibromas of the neck and right foot. References 1. Swapp GH, Main RA: Neurofibromatosis in pregnancy . Br J Dermatol 1973;80:431-435.Crossref 2. Ansari AH, Nagamani M: Pregnancy and neurofibromatosis (von Recklinghausen's disease) . Obstet Gynecol 1976;47:25s-29s. 3. Schwabe AD, Lippe BM, Chang RJ, et al: Anorexia nervosa . Ann Intern Med 1981;94:371-381.Crossref 4. Fabricant RN, Todaro GJ: Increased serum levels of nerve growth factor in von Recklinghausen's disease . Arch Neurol 1981;38:401-405.Crossref 5. Fabricant RN, Todaro GJ: Increased levels of a nervegrowth-factor cross-reacting protein in `central' neurofibromatosis . Lancet 1979;1:4-7.Crossref 6. Kanter WR, Eldridge R, Fabricant R, et al: Central neurofibromatosis: Genetic, clinical and biochemical distinctions from peripheral neurofibromatosis . Neurology 1980;30:851-859.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Eruptive Neurofibromatosis Associated With Anorexia Nervosa

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1983.01650360065016
Publisher site
See Article on Publisher Site

Abstract

Abstract Neurofibromatosis (Recklinghausen's disease) is a well-recognized syndrome transmitted by an autosomal dominant gene. The cutaneous and internal manifestations of the disease have been well known for almost 100 years, but little is known about its pathogenesis. Eruptive neurofibromatosis has previously been reported in association with puberty and pregnancy, suggesting that hormones or growth factors may modulate tumor growth.1,2 We report herein the development of eruptive neurofibromatosis in association with anorexia nervosa. Report of a Case An 18-year-old woman with known neurofibromatosis and anorexia nervosa was seen in April 1981 with a two- to three-week history of the appearance of several hundred papules on her trunk and extremities. She had been previously diagnosed as having neurofibromatosis at 2 years of age, based on the presence of multiple café au lait spots on the trunk and extremities, defective development of the orbital bones, and neurofibromas of the neck and right foot. References 1. Swapp GH, Main RA: Neurofibromatosis in pregnancy . Br J Dermatol 1973;80:431-435.Crossref 2. Ansari AH, Nagamani M: Pregnancy and neurofibromatosis (von Recklinghausen's disease) . Obstet Gynecol 1976;47:25s-29s. 3. Schwabe AD, Lippe BM, Chang RJ, et al: Anorexia nervosa . Ann Intern Med 1981;94:371-381.Crossref 4. Fabricant RN, Todaro GJ: Increased serum levels of nerve growth factor in von Recklinghausen's disease . Arch Neurol 1981;38:401-405.Crossref 5. Fabricant RN, Todaro GJ: Increased levels of a nervegrowth-factor cross-reacting protein in `central' neurofibromatosis . Lancet 1979;1:4-7.Crossref 6. Kanter WR, Eldridge R, Fabricant R, et al: Central neurofibromatosis: Genetic, clinical and biochemical distinctions from peripheral neurofibromatosis . Neurology 1980;30:851-859.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Dec 1, 1983

References