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Erroneous C-Peptide Values Given?-Reply

Erroneous C-Peptide Values Given?-Reply Abstract —Thank you for your comments on C-peptide methodology, which are quite correct, regarding interference from insulin antibodies. The levels reported in the letter we published were obtained before precipitation of antibodies (nonpolyethylene glycol [PEG] values). However, on the day after the first determination, the assay was repeated after PEG precipitation of antibodies. This produced a normal C-peptide response to glucose, given in the Table. The method was that of Kuzuya et al.1 All values of C-peptide obtained using PEG are comparable to values obtained using the C-peptide methodology in glucose tolerance testing from normal persons. References 1. Kuzuya H, Blix PM, Horwitz DC, et al: Determination of free and total insulin and C-peptide in insulin-treated diabetics. Diabetes 1977;26:22-29.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Erroneous C-Peptide Values Given?-Reply

Abstract

Abstract —Thank you for your comments on C-peptide methodology, which are quite correct, regarding interference from insulin antibodies. The levels reported in the letter we published were obtained before precipitation of antibodies (nonpolyethylene glycol [PEG] values). However, on the day after the first determination, the assay was repeated after PEG precipitation of antibodies. This produced a normal C-peptide response to glucose, given in the Table. The method was that of Kuzuya et...
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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340140203043
Publisher site
See Article on Publisher Site

Abstract

Abstract —Thank you for your comments on C-peptide methodology, which are quite correct, regarding interference from insulin antibodies. The levels reported in the letter we published were obtained before precipitation of antibodies (nonpolyethylene glycol [PEG] values). However, on the day after the first determination, the assay was repeated after PEG precipitation of antibodies. This produced a normal C-peptide response to glucose, given in the Table. The method was that of Kuzuya et al.1 All values of C-peptide obtained using PEG are comparable to values obtained using the C-peptide methodology in glucose tolerance testing from normal persons. References 1. Kuzuya H, Blix PM, Horwitz DC, et al: Determination of free and total insulin and C-peptide in insulin-treated diabetics. Diabetes 1977;26:22-29.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jan 1, 1982

References