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ERRONEOUS ANEMIA AND POLYCYTHEMIA: A Comparative Study of Peripheral Blood and Blood Volume

ERRONEOUS ANEMIA AND POLYCYTHEMIA: A Comparative Study of Peripheral Blood and Blood Volume Abstract THE PHENOMENA of erroneous anemia and polycythemia as related to blood volume have been given little attention. The red cell mass and circulating hemoglobin may be entirely normal in a person in whom the peripheral blood elements and hemoglobin concentration are below the accepted normal values. Pseudo-polycythemia may be caused by a decreased plasma volume. Even in polycythemia vera there may be a lack of correlation between the peripheral blood and the blood volume. This report presents the results of simultaneous studies of the peripheral blood and blood volume in 62 human subjects, 13 with "anemia of neurasthenia," 17 with a decreased plasma volume, 17 with normal and pathologic pregnancy, and 15 with polycythemia vera. METHODS Blood volume and peripheral blood studies were done simultaneously so that the results could be correlated. The hemoglobin concentration was determined by the oxyhemoglobin method of Sheard and Sanford,1 using a Coleman Junior References 1. Sheard, C., and Sanford, A. H.: Photoelectric Hemoglobinometer: Clinical Application of Principles of Photoelectric Photometry to Measurement of Hemoglobin , J. Lab. & Clin. Med. 14:558,1929. 2. Wong, S. Y.: Colorimetric Determination of Iron and Hemoglobin in Blood , J. Biol. Chem. 55:421, 1923 3. 77:409, 1928. 4. Dupray, M.: Colorimetric Method for Determination of Iron and Hemoglobin in Blood , J. Lab. & Clin. Med. 12:917, 1927. 5. Walker, B. S., and Fitz, R.: Clinical Observations on Blood Iron , Ann. Int. Med. 14:263, 1940. 6. Ponder, E.: Relation Between Red Blood Cell Density and Corpuscular Hemoglobin Concentration , J. Biol. Chem. 144:333, 1942. 7. Exton, W. G.; Schattner, F., and Rose, A. R.: Acidosis and Alkalosis: Clinical Significance and Measurement of Colorimetry of Plasma CO2 Capacity , Am. J. Clin. Path. 11:632, 1941. 8. Exton, W. G.; Schattner, F.; Korman, S., and Rose, A. R.: Colorimetric Method for Determining Available Oxygen in Blood , J. Lab. & Clin. Med. 30:84, 1945. 9. Gregersen, M. I.: Practical Method for Determination of Blood Volume with Dye T-1824: Survey of Present Basis of Dye-Method and Its Clinical Applications , J. Lab. & Clin. Med. 29:1266, 1944. 10. Gibson, J. G., and Evans, W. A.: Clinical Application of Method Employing Azo Dye "Evans Blue" and Spectrophotometer , J. Clin. Invest. 16:301, 1937 11. Relation of Plasma and Total Blood Volume to Venous Pressure, Blood Velocity Rate, Physical Measurements, Age, and Sex in 90 Normal Humans , Gibson J. Clin. Invest. 16:17, 1937. 12. Wintrobe, M. M.: Clinical Hematology , Ed. 3, Philadelphia, Lea & Febiger, 1951. 13. Dameshek, W.: Anemia of Neurasthenia, editorial , Blood 2:485, 1947. 14. Portis, S. A.: Mechanism of Fatigue in Neuropsychiatric Patients , J. A. M. A. 121:569, 1943 15. The Medical Treatment of Psychosomatic Disturbances with Special Reference to Gastrointestinal Tract and Fatigue , Portis J. A. M. A. 126:413, 1944. 16. Alexander, F., and Portis, S. A.: A Psychosomatic Study of Hypoglycemic Fatigue , Psychosom. Med. 6:19, 1944. 17. Tysoe, R. W., and Lowenstein, L.: Blood Volume and Hematologic Studies in Pregnancy and Puerperium , Am. J. Obst. & Gynec. 60:1187, 1950. 18. Dieckmann, W. J., and Wegner, C. R.: Studies of Blood in Normal Pregnancy: I. Blood and Plasma Volumes , Arch. Int. Med. 53:71, 1934. 19. Thomson, K. J.; Hirsheimer, A.; Gibson, J. G., and Evans. W. A., Sr.: Studies on Circulation in Pregnancy: III. Blood Volume Changes in Normal Pregnant Women , Am. J. Obst. & Gynec. 36:48, 1939. 20. Caton, W. L.; Roby, C. C.; Reid, D. E., and Gibson, J. G.: Plasma Volume and Extravascular Fluid Volume During Pregnancy and Puerperium , Am. J. Obst. & Gynec. 57:471, 1949. 21. Erlanger, J.: Blood Volume and Its Regulation , Physiol. Rev. 1:177, 1921. 22. Rowntree, L. G.; Brown, G. E., and Roth, G. M.: The Volume of Blood and Plasma in Health and Disease , Philadelphia, W. B. Saunders Company, 1929. 23. Gibson, J. G.; Harris, A. W., and Swigert, V. W.: Macrocytic and Hypochromic Anemias Due to Chronic Blood Loss, Hemolysis, and Miscellaneous Causes, and Polycythemia Vera , J. Clin. Invest. 18:621, 1939. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

ERRONEOUS ANEMIA AND POLYCYTHEMIA: A Comparative Study of Peripheral Blood and Blood Volume

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Publisher
American Medical Association
Copyright
Copyright © 1952 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1952.00240110028004
Publisher site
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Abstract

Abstract THE PHENOMENA of erroneous anemia and polycythemia as related to blood volume have been given little attention. The red cell mass and circulating hemoglobin may be entirely normal in a person in whom the peripheral blood elements and hemoglobin concentration are below the accepted normal values. Pseudo-polycythemia may be caused by a decreased plasma volume. Even in polycythemia vera there may be a lack of correlation between the peripheral blood and the blood volume. This report presents the results of simultaneous studies of the peripheral blood and blood volume in 62 human subjects, 13 with "anemia of neurasthenia," 17 with a decreased plasma volume, 17 with normal and pathologic pregnancy, and 15 with polycythemia vera. METHODS Blood volume and peripheral blood studies were done simultaneously so that the results could be correlated. The hemoglobin concentration was determined by the oxyhemoglobin method of Sheard and Sanford,1 using a Coleman Junior References 1. Sheard, C., and Sanford, A. H.: Photoelectric Hemoglobinometer: Clinical Application of Principles of Photoelectric Photometry to Measurement of Hemoglobin , J. Lab. & Clin. Med. 14:558,1929. 2. Wong, S. Y.: Colorimetric Determination of Iron and Hemoglobin in Blood , J. Biol. Chem. 55:421, 1923 3. 77:409, 1928. 4. Dupray, M.: Colorimetric Method for Determination of Iron and Hemoglobin in Blood , J. Lab. & Clin. Med. 12:917, 1927. 5. Walker, B. S., and Fitz, R.: Clinical Observations on Blood Iron , Ann. Int. Med. 14:263, 1940. 6. Ponder, E.: Relation Between Red Blood Cell Density and Corpuscular Hemoglobin Concentration , J. Biol. Chem. 144:333, 1942. 7. Exton, W. G.; Schattner, F., and Rose, A. R.: Acidosis and Alkalosis: Clinical Significance and Measurement of Colorimetry of Plasma CO2 Capacity , Am. J. Clin. Path. 11:632, 1941. 8. Exton, W. G.; Schattner, F.; Korman, S., and Rose, A. R.: Colorimetric Method for Determining Available Oxygen in Blood , J. Lab. & Clin. Med. 30:84, 1945. 9. Gregersen, M. I.: Practical Method for Determination of Blood Volume with Dye T-1824: Survey of Present Basis of Dye-Method and Its Clinical Applications , J. Lab. & Clin. Med. 29:1266, 1944. 10. Gibson, J. G., and Evans, W. A.: Clinical Application of Method Employing Azo Dye "Evans Blue" and Spectrophotometer , J. Clin. Invest. 16:301, 1937 11. Relation of Plasma and Total Blood Volume to Venous Pressure, Blood Velocity Rate, Physical Measurements, Age, and Sex in 90 Normal Humans , Gibson J. Clin. Invest. 16:17, 1937. 12. Wintrobe, M. M.: Clinical Hematology , Ed. 3, Philadelphia, Lea & Febiger, 1951. 13. Dameshek, W.: Anemia of Neurasthenia, editorial , Blood 2:485, 1947. 14. Portis, S. A.: Mechanism of Fatigue in Neuropsychiatric Patients , J. A. M. A. 121:569, 1943 15. The Medical Treatment of Psychosomatic Disturbances with Special Reference to Gastrointestinal Tract and Fatigue , Portis J. A. M. A. 126:413, 1944. 16. Alexander, F., and Portis, S. A.: A Psychosomatic Study of Hypoglycemic Fatigue , Psychosom. Med. 6:19, 1944. 17. Tysoe, R. W., and Lowenstein, L.: Blood Volume and Hematologic Studies in Pregnancy and Puerperium , Am. J. Obst. & Gynec. 60:1187, 1950. 18. Dieckmann, W. J., and Wegner, C. R.: Studies of Blood in Normal Pregnancy: I. Blood and Plasma Volumes , Arch. Int. Med. 53:71, 1934. 19. Thomson, K. J.; Hirsheimer, A.; Gibson, J. G., and Evans. W. A., Sr.: Studies on Circulation in Pregnancy: III. Blood Volume Changes in Normal Pregnant Women , Am. J. Obst. & Gynec. 36:48, 1939. 20. Caton, W. L.; Roby, C. C.; Reid, D. E., and Gibson, J. G.: Plasma Volume and Extravascular Fluid Volume During Pregnancy and Puerperium , Am. J. Obst. & Gynec. 57:471, 1949. 21. Erlanger, J.: Blood Volume and Its Regulation , Physiol. Rev. 1:177, 1921. 22. Rowntree, L. G.; Brown, G. E., and Roth, G. M.: The Volume of Blood and Plasma in Health and Disease , Philadelphia, W. B. Saunders Company, 1929. 23. Gibson, J. G.; Harris, A. W., and Swigert, V. W.: Macrocytic and Hypochromic Anemias Due to Chronic Blood Loss, Hemolysis, and Miscellaneous Causes, and Polycythemia Vera , J. Clin. Invest. 18:621, 1939.

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Nov 1, 1952

References