Opinion EDITORIAL A Step Closer to Understanding Who, Where, and When Jennifer A. Blumenthal, MD; Jeffrey P. Burns, MD, MPH Death and disease in adult patients from the COVID-19 pan- more frequently with conjunctival findings, rash, and abdomi- demic continue unabated across the world well into 2021, and nal pain, while adolescents present more frequently with chest pain, shortness of breath, and cough. In this study, cardiac dys- why children have escaped severe disease from this virus re- mains one of the most intriguing gaps in our understanding function and a diagnosis of myocarditis was significantly more of the immune response to likely in adolescents. Most notably, this study of MIS-C found this virus. Of equal impera- no significant difference in the age of children with coronary Related article tive, what insights can be artery dilation. Coronary artery dilation was found in 18.3% gained via a deeper understanding as to why some children of children aged 0 to 4 years and 14.6% of children aged 18 to do become critically ill from COVID-19 and the more recently 20 years. described multisystem inflammatory syndrome in children Second, this study defines characteristics of MIS-C by pre- (MIS-C)? Unlocking the key immunologic
JAMA Pediatrics – American Medical Association
Published: Aug 6, 2021
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