Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Epidemic Occurrence of Neonatal Necrotizing Enterocolitis

Epidemic Occurrence of Neonatal Necrotizing Enterocolitis Abstract • In case-control studies of three epidemics of neonatal necrotizing enterocolitis (NEC) in three different high-risk nurseries in three states, no particular risk factor was associated with affected infants or their mothers. Epidemic cases had higher birth weights and Apgar scores and fewer perinatal difficulties than those previously reported for sporadic cases. Seven infants fed primarily breast milk were not protected against disease. Early antibiotic therapy was associated with a significantly decreased risk of disease in one outbreak. In two hospitals, affected infants who received antibiotic therapy during the first three days of life had a significantly later disease onset. The occurrence of the disease in epidemics and the decreased risk or modification of disease with antibiotic therapy support an infectious etiology for NEC. (Am J Dis Child 133:594-597, 1979) References 1. Mizrahi A, Barlow O, Bordon W, et al: Necrotizing enterocolitis in premature infants . J Pediatr 66:697-706, 1965.Crossref 2. Chappel JC, Dinner M: Neonatal necrotizing enterocolitis . S Afr J Surg 10:215-219, 1972. 3. Stein H, Beck J, Solomon A, et al: Gastroenteritis with necrotizing enterocolitis in premature babies . Br Med J 2:616-619, 1972.Crossref 4. Bhargava SK, Mittal SK, Saxena HMK, et al: An outbreak of necrotizing enterocolitis in a special care newborn nursery . Indian Pediatr 10:551-553, 1973. 5. Virnig NL, Reynolds JW: Epidemiologic aspects of neonatal necrotizing enterocolitis . Am J Dis Child 128:186-190, 1974. 6. Desai NS, Cunningham MD, Wilson HD: Nosocomial epidemics of neonatal necrotizing enterocolitis . Pediatr Res 9:296, 1975. 7. Barlow B, Santulli T, Heird WC, et al: An experimental study of acute neonatal enterocolitis: The importance of breast milk . J Pediatr Surg 9:587-595, 1974.Crossref 8. Egan EA, Bonzalo M, Nelson RM, et al: A prospective controlled trial of oral kanamycin in the prevention of neonatal necrotizing enterocolitis . J Pediatr 89:467-470, 1976.Crossref 9. Hill HR, Hunt CD, Matsen JM: Nosocomial colonization with Klebsiella, type 26, in a neonatal intensive care unit associated with an outbreak of sepsis, meningitis, and necrotizing enterocolitis . J Pediatr 85:415-419, 1974.Crossref 10. Frantz ID, L'heureaux P, Engle RR, et al: Necrotizing enterocolitis . J Pediatr 86:259-263, 1975.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Epidemic Occurrence of Neonatal Necrotizing Enterocolitis

Download PDF
4 pages

Loading next page...
 
/lp/american-medical-association/epidemic-occurrence-of-neonatal-necrotizing-enterocolitis-9G2MstbgxF

References (10)

Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1979.02130060034005
Publisher site
See Article on Publisher Site

Abstract

Abstract • In case-control studies of three epidemics of neonatal necrotizing enterocolitis (NEC) in three different high-risk nurseries in three states, no particular risk factor was associated with affected infants or their mothers. Epidemic cases had higher birth weights and Apgar scores and fewer perinatal difficulties than those previously reported for sporadic cases. Seven infants fed primarily breast milk were not protected against disease. Early antibiotic therapy was associated with a significantly decreased risk of disease in one outbreak. In two hospitals, affected infants who received antibiotic therapy during the first three days of life had a significantly later disease onset. The occurrence of the disease in epidemics and the decreased risk or modification of disease with antibiotic therapy support an infectious etiology for NEC. (Am J Dis Child 133:594-597, 1979) References 1. Mizrahi A, Barlow O, Bordon W, et al: Necrotizing enterocolitis in premature infants . J Pediatr 66:697-706, 1965.Crossref 2. Chappel JC, Dinner M: Neonatal necrotizing enterocolitis . S Afr J Surg 10:215-219, 1972. 3. Stein H, Beck J, Solomon A, et al: Gastroenteritis with necrotizing enterocolitis in premature babies . Br Med J 2:616-619, 1972.Crossref 4. Bhargava SK, Mittal SK, Saxena HMK, et al: An outbreak of necrotizing enterocolitis in a special care newborn nursery . Indian Pediatr 10:551-553, 1973. 5. Virnig NL, Reynolds JW: Epidemiologic aspects of neonatal necrotizing enterocolitis . Am J Dis Child 128:186-190, 1974. 6. Desai NS, Cunningham MD, Wilson HD: Nosocomial epidemics of neonatal necrotizing enterocolitis . Pediatr Res 9:296, 1975. 7. Barlow B, Santulli T, Heird WC, et al: An experimental study of acute neonatal enterocolitis: The importance of breast milk . J Pediatr Surg 9:587-595, 1974.Crossref 8. Egan EA, Bonzalo M, Nelson RM, et al: A prospective controlled trial of oral kanamycin in the prevention of neonatal necrotizing enterocolitis . J Pediatr 89:467-470, 1976.Crossref 9. Hill HR, Hunt CD, Matsen JM: Nosocomial colonization with Klebsiella, type 26, in a neonatal intensive care unit associated with an outbreak of sepsis, meningitis, and necrotizing enterocolitis . J Pediatr 85:415-419, 1974.Crossref 10. Frantz ID, L'heureaux P, Engle RR, et al: Necrotizing enterocolitis . J Pediatr 86:259-263, 1975.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: Jun 1, 1979

There are no references for this article.