Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Eosinophilic Pustular Folliculitis (Ofuji's Disease): Immunohistochemical Analysis

Eosinophilic Pustular Folliculitis (Ofuji's Disease): Immunohistochemical Analysis Abstract Background: Eosinophilic pustular folliculitis is a distinctive dermatosis that was first described in Japan. Although the histopathologic feature of eosinophilic pustular folliculitis is characterized by follicular infiltrates with numerous eosinophils, its pathophysiology remains unclear. The lesional skin of five patients with eosinophilic pustular folliculitis was examined using several monoclonal antibodies including a variety of anti-leukocyte adhesion molecules: endothelial cell adhesion molecule 1, vascular cell adhesion molecule 1, and intercellular adhesion molecule 1, by means of immunohistochemical techniques. Observation: Intercellular adhesion molecule 1 expression by keratinocytes was observed on follicular epithelium, but not on epidermis. The migration of eosinophils and lymphocytes, which were intensely positive for anti-lymphocyte function-associated antigen 1, was limited to follicular epithelium. Endothelial cell adhesion molecule 1 and vascular cell adhesion molecule 1 expression of vascular endothelium was more often observed around hair follicles. There was no reactivity for interleukin 8 in follicular epithelium. Conclusions: These findings may explain the selective migration of eosinophils and lymphocytes to the hair follicles in eosinophilic pustular folliculitis.(Arch Dermatol. 1993;129:1015-1019) References 1. Ofuji S, Ogino A, Horio T, Ohseko T, Uehara M. Eosinophilic pustular folliculitis . Acta Derm Venereol (Stockh). 1970;50:195-203. 2. Soeprono FF, Schinella RA. Eosinophilic pustular folliculitis with acquired immunodeficiency syndrome . J Am Acad Dermatol. 1986;14:1020-1022.Crossref 3. Buchness MR, Lim HW, Hatcher VA, Sanchez M, Soter NA. Eosinophilic pustular folliculitis in the acquired immunodeficiency syndrome . N Engl J Med. 1988;318:1183-1186.Crossref 4. Rosenthal D, LeBoit PE, Klumpp L, Berger TG. Human immunodeficiency virusassociated eosinophilic folliculitis . Arch Dermatol. 1991;127:206-209.Crossref 5. Breit R, Röcken M. Klassische Form einer eosinophilen Pustulösen Follikulitiserfolgreiche Therapie mit PUVA . Hautarzt. 1991;42:247-250. 6. Springer TA. Adhesion receptors of immune system . Nature. 1990;346:425-434.Crossref 7. Dobrina A, Menegazzi R, Carlos TM, et al. Mechanisms of eosinophil adherence to cultured vascular endothelial cells . J Clin Invest. 1991;88:20-26.Crossref 8. Takematsu H, Nakamura K, Igarashi M, Tagami H. Eosinophilic pustular folliculitis: report of two cases with a review of the Japanese literature . Arch Dermatol. 1985;121:917-920.Crossref 9. Shiohara T, Moriya N, Tanaka Y, et al. Immunopathologic study of lichenoid skin disease: correlation between HLA-DR positive keratinocytes or Langerhans cells and epidermotropic T cells . J Am Acad Dermatol. 1988;18:67-74.Crossref 10. Barker JNWN, Macdonald DM. Cutaneous lymphocyte trafficking in the inflammatory dermatoses . Br J Dermatol. 1992;126:211-215.Crossref 11. Weller PF. The immunology of eosinophils . N Engl J Med. 1991;324:1110-1118.Crossref 12. Wegner CD, Gundel RH, Reilly P, Haynes N, Letts LG, Rothlein R. Intercellular adhesion molecule—1 (ICAM-1) in the pathogenesis of asthma . Science. 1990; 247:456-459.Crossref 13. Picker LJ, Kishimoto TK, Smith CW, Warnock RA, Butcher EC. ELAM-1 is an adhesion molecule for skin-homing T cells . Nature. 1991;349:796-799.Crossref 14. Bochner BS, Luscinskas FW, Gimbrone MA, et al. Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1—activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules . J Exp Med. 1991;173:1553-1556.Crossref 15. Weller PF, Rand TH, Goelz SE, Chi-Rosso G, Lobb RR. Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1 . Proc Natl Acad Sci U S A. 1991;88:7430-7433.Crossref 16. Barker JNWN, Jones ML, Mitra RJ, et al. Modulation of keratinocyte-derived interleukin-8 which is chemotactic for neutrophils and lymphocytes . Am J Pathol. 1991;139:869-876. 17. Takematsu H, Tagami H. Eosinophilic pustular folliculitis: studies on possible chemotactic factors involved in the formation of pustules . Br J Dermatol. 1986; 114:209-215.Crossref 18. Barker JNWN, Mitra RJ, Griffiths CEM, Dixit VM, Nickoloff BJ. Keratinocytes as initiators of inflammation . Lancet. 1991;337:211-214.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Eosinophilic Pustular Folliculitis (Ofuji's Disease): Immunohistochemical Analysis

Loading next page...
 
/lp/american-medical-association/eosinophilic-pustular-folliculitis-ofuji-s-disease-immunohistochemical-JK8012hb1D
Publisher
American Medical Association
Copyright
Copyright © 1993 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1993.01680290087013
Publisher site
See Article on Publisher Site

Abstract

Abstract Background: Eosinophilic pustular folliculitis is a distinctive dermatosis that was first described in Japan. Although the histopathologic feature of eosinophilic pustular folliculitis is characterized by follicular infiltrates with numerous eosinophils, its pathophysiology remains unclear. The lesional skin of five patients with eosinophilic pustular folliculitis was examined using several monoclonal antibodies including a variety of anti-leukocyte adhesion molecules: endothelial cell adhesion molecule 1, vascular cell adhesion molecule 1, and intercellular adhesion molecule 1, by means of immunohistochemical techniques. Observation: Intercellular adhesion molecule 1 expression by keratinocytes was observed on follicular epithelium, but not on epidermis. The migration of eosinophils and lymphocytes, which were intensely positive for anti-lymphocyte function-associated antigen 1, was limited to follicular epithelium. Endothelial cell adhesion molecule 1 and vascular cell adhesion molecule 1 expression of vascular endothelium was more often observed around hair follicles. There was no reactivity for interleukin 8 in follicular epithelium. Conclusions: These findings may explain the selective migration of eosinophils and lymphocytes to the hair follicles in eosinophilic pustular folliculitis.(Arch Dermatol. 1993;129:1015-1019) References 1. Ofuji S, Ogino A, Horio T, Ohseko T, Uehara M. Eosinophilic pustular folliculitis . Acta Derm Venereol (Stockh). 1970;50:195-203. 2. Soeprono FF, Schinella RA. Eosinophilic pustular folliculitis with acquired immunodeficiency syndrome . J Am Acad Dermatol. 1986;14:1020-1022.Crossref 3. Buchness MR, Lim HW, Hatcher VA, Sanchez M, Soter NA. Eosinophilic pustular folliculitis in the acquired immunodeficiency syndrome . N Engl J Med. 1988;318:1183-1186.Crossref 4. Rosenthal D, LeBoit PE, Klumpp L, Berger TG. Human immunodeficiency virusassociated eosinophilic folliculitis . Arch Dermatol. 1991;127:206-209.Crossref 5. Breit R, Röcken M. Klassische Form einer eosinophilen Pustulösen Follikulitiserfolgreiche Therapie mit PUVA . Hautarzt. 1991;42:247-250. 6. Springer TA. Adhesion receptors of immune system . Nature. 1990;346:425-434.Crossref 7. Dobrina A, Menegazzi R, Carlos TM, et al. Mechanisms of eosinophil adherence to cultured vascular endothelial cells . J Clin Invest. 1991;88:20-26.Crossref 8. Takematsu H, Nakamura K, Igarashi M, Tagami H. Eosinophilic pustular folliculitis: report of two cases with a review of the Japanese literature . Arch Dermatol. 1985;121:917-920.Crossref 9. Shiohara T, Moriya N, Tanaka Y, et al. Immunopathologic study of lichenoid skin disease: correlation between HLA-DR positive keratinocytes or Langerhans cells and epidermotropic T cells . J Am Acad Dermatol. 1988;18:67-74.Crossref 10. Barker JNWN, Macdonald DM. Cutaneous lymphocyte trafficking in the inflammatory dermatoses . Br J Dermatol. 1992;126:211-215.Crossref 11. Weller PF. The immunology of eosinophils . N Engl J Med. 1991;324:1110-1118.Crossref 12. Wegner CD, Gundel RH, Reilly P, Haynes N, Letts LG, Rothlein R. Intercellular adhesion molecule—1 (ICAM-1) in the pathogenesis of asthma . Science. 1990; 247:456-459.Crossref 13. Picker LJ, Kishimoto TK, Smith CW, Warnock RA, Butcher EC. ELAM-1 is an adhesion molecule for skin-homing T cells . Nature. 1991;349:796-799.Crossref 14. Bochner BS, Luscinskas FW, Gimbrone MA, et al. Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1—activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules . J Exp Med. 1991;173:1553-1556.Crossref 15. Weller PF, Rand TH, Goelz SE, Chi-Rosso G, Lobb RR. Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1 . Proc Natl Acad Sci U S A. 1991;88:7430-7433.Crossref 16. Barker JNWN, Jones ML, Mitra RJ, et al. Modulation of keratinocyte-derived interleukin-8 which is chemotactic for neutrophils and lymphocytes . Am J Pathol. 1991;139:869-876. 17. Takematsu H, Tagami H. Eosinophilic pustular folliculitis: studies on possible chemotactic factors involved in the formation of pustules . Br J Dermatol. 1986; 114:209-215.Crossref 18. Barker JNWN, Mitra RJ, Griffiths CEM, Dixit VM, Nickoloff BJ. Keratinocytes as initiators of inflammation . Lancet. 1991;337:211-214.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1993

References