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Eosinophilic Granuloma: Presence of OKT6-Positive Cells and Good Response to Intralesional Steroid

Eosinophilic Granuloma: Presence of OKT6-Positive Cells and Good Response to Intralesional Steroid Abstract • A patient with eosinophilic granuloma, with extensive oral mucous membrane involvement, was treated with intralesional triamcinolone acetonide injections. Although radiation therapy had failed, this treatment resulted in remission. The biopsy specimen from the patient's lesion contained a predominance of OKT6-positive cells, which were shown by electron microscopic analysis to be mostly indeterminate cells and a small percentage of Langerhans' cells, with characteristic L-cell granules; there was also 5% eosinophils. Many L-cell granules were being produced between cell membranes of the same as well as neighboring L cells. It was thought that in this condition, as in other proliferative conditions of L cells, cell membranes are extremely adhesive and that such adhesion areas of L cells form L-cell granules. This occurs in a similar fashion as the adhesive areas of epithelial cells form desmosomes. (Arch Dermatol 1985;121:770-774) References 1. Lieberman PH: Langerhans cell (eosinophilic) granulomatosis . J Invest Dermatol 1980;75:71-72.Crossref 2. Lever W, Schaumburg-Lever G: Histopathology of the Skin , ed 6. Philadelphia, JB Lippincott Co, 1983, pp 392-396. 3. Wolff K: Langerhans cell . Curr Probl Dermatol 1972;4:79-145. 4. Falini B, Taylor CR: New developments in immunoperoxidase techniques and their application . Arch Pathol Lab Med 1983; 107:105-117. 5. Murphy GF, Bhan AK, Sato S, et al: A new immunologic marker for Langerhans cells . N Engl J Med 1981;34:791-792. 6. Murphy GF, Bhan AK, Harrist TJ, et al: Identification of indeterminate cells in normal human dermis by the use of monoclonal anti-T6 antibody, abstracted . Lab Invest 1982; 46:60. 7. Schuler G, Stingl G, Aberer W, et al: Histiocytosis X cells in eosinophilic granuloma express Ia and T6 antigens . J Invest Dermatol 1983;80:405-409.Crossref 8. Hashimoto K, Takahashi S, Lee RG, et al: Congenital self-healing reticulohistiocytosis (a report on seventh case with histochemical and ultrastructural studies) . J Am Acad Dermatol 1984;11:447-454.Crossref 9. Caputo R, Gianotti F: Junctions between histiocytes: Role of coated vesicles . J Ultrastruct Res 1979;68:256-264.Crossref 10. Overton J: The fate of desmosomes in trypsinized tissue . J Exp Zool 1968;168:203-206.Crossref 11. Mutasim DF, Takahashi Y, Labib RS, et al: A pool of bullous pemphigoid antigen(s) is intracellular and associated with the basal cell cytoskeleton-hemidesmosome complex . J Invest Dermatol 1985;84:47-53.Crossref 12. Westgate GE, Weaver AC, Couchman JR: Bullous pemphigoid antigen localization suggests an intracellular association with hemidesmosomes . J Invest Dermatol 1985;84:218-224.Crossref 13. Hashimoto K, Tarnowski WM: Some new aspects of the Langerhans cell . Arch Dermatol 1968;97:450-464.Crossref 14. Hashimoto K: Langerhans' cell granule . Arch Dermatol 1971;104:148-160.Crossref 15. Masutani M, Hashimoto K: Phagocytic and lysosomal activity of Langerhans cells in sensitized guinea pig, abstracted . J Invest Dermatol 1979;72:281. 16. Takahashi S, Hashimoto K: Derivation of Langerhans cell granules from cytomembrane, abstracted . J Invest Dermatol 1983;80:345. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Eosinophilic Granuloma: Presence of OKT6-Positive Cells and Good Response to Intralesional Steroid

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Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1985.01660060084027
Publisher site
See Article on Publisher Site

Abstract

Abstract • A patient with eosinophilic granuloma, with extensive oral mucous membrane involvement, was treated with intralesional triamcinolone acetonide injections. Although radiation therapy had failed, this treatment resulted in remission. The biopsy specimen from the patient's lesion contained a predominance of OKT6-positive cells, which were shown by electron microscopic analysis to be mostly indeterminate cells and a small percentage of Langerhans' cells, with characteristic L-cell granules; there was also 5% eosinophils. Many L-cell granules were being produced between cell membranes of the same as well as neighboring L cells. It was thought that in this condition, as in other proliferative conditions of L cells, cell membranes are extremely adhesive and that such adhesion areas of L cells form L-cell granules. This occurs in a similar fashion as the adhesive areas of epithelial cells form desmosomes. (Arch Dermatol 1985;121:770-774) References 1. Lieberman PH: Langerhans cell (eosinophilic) granulomatosis . J Invest Dermatol 1980;75:71-72.Crossref 2. Lever W, Schaumburg-Lever G: Histopathology of the Skin , ed 6. Philadelphia, JB Lippincott Co, 1983, pp 392-396. 3. Wolff K: Langerhans cell . Curr Probl Dermatol 1972;4:79-145. 4. Falini B, Taylor CR: New developments in immunoperoxidase techniques and their application . Arch Pathol Lab Med 1983; 107:105-117. 5. Murphy GF, Bhan AK, Sato S, et al: A new immunologic marker for Langerhans cells . N Engl J Med 1981;34:791-792. 6. Murphy GF, Bhan AK, Harrist TJ, et al: Identification of indeterminate cells in normal human dermis by the use of monoclonal anti-T6 antibody, abstracted . Lab Invest 1982; 46:60. 7. Schuler G, Stingl G, Aberer W, et al: Histiocytosis X cells in eosinophilic granuloma express Ia and T6 antigens . J Invest Dermatol 1983;80:405-409.Crossref 8. Hashimoto K, Takahashi S, Lee RG, et al: Congenital self-healing reticulohistiocytosis (a report on seventh case with histochemical and ultrastructural studies) . J Am Acad Dermatol 1984;11:447-454.Crossref 9. Caputo R, Gianotti F: Junctions between histiocytes: Role of coated vesicles . J Ultrastruct Res 1979;68:256-264.Crossref 10. Overton J: The fate of desmosomes in trypsinized tissue . J Exp Zool 1968;168:203-206.Crossref 11. Mutasim DF, Takahashi Y, Labib RS, et al: A pool of bullous pemphigoid antigen(s) is intracellular and associated with the basal cell cytoskeleton-hemidesmosome complex . J Invest Dermatol 1985;84:47-53.Crossref 12. Westgate GE, Weaver AC, Couchman JR: Bullous pemphigoid antigen localization suggests an intracellular association with hemidesmosomes . J Invest Dermatol 1985;84:218-224.Crossref 13. Hashimoto K, Tarnowski WM: Some new aspects of the Langerhans cell . Arch Dermatol 1968;97:450-464.Crossref 14. Hashimoto K: Langerhans' cell granule . Arch Dermatol 1971;104:148-160.Crossref 15. Masutani M, Hashimoto K: Phagocytic and lysosomal activity of Langerhans cells in sensitized guinea pig, abstracted . J Invest Dermatol 1979;72:281. 16. Takahashi S, Hashimoto K: Derivation of Langerhans cell granules from cytomembrane, abstracted . J Invest Dermatol 1983;80:345.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jun 1, 1985

References