Key PointsQuestionHow representative are contemporary heart failure (HF) trials with respect to age, sex, and race/ethnicity? FindingsIn a systematic review of 118 HF clinical trials, the mean age of participants was 65 years, 27% were women, and there were no significant temporal changes in age and sex trends over time. Race/ethnicity distribution was reported in less than half of trials, and in trials with available data, enrollment of nonwhite patients increased steadily from 13% to 30% over time. MeaningDifferences in traditionally underrepresented patient groups between trials and epidemiologic studies persist but are less than previously reported. Enrollment of racial and ethnic minorities has improved over time but may be subject to reporting bias.
JAMA Cardiology – American Medical Association
Published: Oct 22, 2018