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Enrollment of Older Patients, Women, and Racial and Ethnic Minorities in Contemporary Heart Failure Clinical Trials

Enrollment of Older Patients, Women, and Racial and Ethnic Minorities in Contemporary Heart... Key PointsQuestionHow representative are contemporary heart failure (HF) trials with respect to age, sex, and race/ethnicity? FindingsIn a systematic review of 118 HF clinical trials, the mean age of participants was 65 years, 27% were women, and there were no significant temporal changes in age and sex trends over time. Race/ethnicity distribution was reported in less than half of trials, and in trials with available data, enrollment of nonwhite patients increased steadily from 13% to 30% over time. MeaningDifferences in traditionally underrepresented patient groups between trials and epidemiologic studies persist but are less than previously reported. Enrollment of racial and ethnic minorities has improved over time but may be subject to reporting bias. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Cardiology American Medical Association

Enrollment of Older Patients, Women, and Racial and Ethnic Minorities in Contemporary Heart Failure Clinical Trials

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
2380-6583
eISSN
2380-6591
DOI
10.1001/jamacardio.2018.2559
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionHow representative are contemporary heart failure (HF) trials with respect to age, sex, and race/ethnicity? FindingsIn a systematic review of 118 HF clinical trials, the mean age of participants was 65 years, 27% were women, and there were no significant temporal changes in age and sex trends over time. Race/ethnicity distribution was reported in less than half of trials, and in trials with available data, enrollment of nonwhite patients increased steadily from 13% to 30% over time. MeaningDifferences in traditionally underrepresented patient groups between trials and epidemiologic studies persist but are less than previously reported. Enrollment of racial and ethnic minorities has improved over time but may be subject to reporting bias.

Journal

JAMA CardiologyAmerican Medical Association

Published: Oct 22, 2018

References