Abstract • Metoclopramide hydrochloride was administered to nine children for the treatment of gastric stasis (N = 6) and unexplained vomiting (N = 3). One additional patient with gastric stasis displayed no response to the test dose of metoclopramide. Both the frequency and apparent forcefulness of the gastric and duodenal waves increased with the administration of metoclopramide in the nine patients receiving treatment. Eight clinical aspects were monitored, with improvement seen in all during therapy; the rates of both improvement and freedom from symptoms were time dependent. After one month, the median rate of improvement in individual symptoms was 86%, and the median rate of freedom from symptoms was 54%. Only two of the nine patients became totally asymptomatic within the month. However, sustained improvement was maintained after discontinuance of metoclopramide administration. Within the administered dosages and within the study population, metoclopramide was found to be safe. (Am J Dis Child 1982;136:299-302) References 1. Justin-Besancon L, Laville C, Thominet M: Le metoclopramide et ses homologues: Introduction a leur etude biologique . CR Acad Sci 1964;258:4384-4386. 2. McClelland RN, Horton JW: Relief of acute persistent postvagotomy atony by metoclopramide . Ann Surg 1978;188:439-447. 3. Perkel MS, Moore C, Hersh T, et al: Metoclopramide therapy in patients with delayed gastric emptying: A randomized, double-blind study . Dig Dis Sci 1979;24:662-666.Crossref 4. Banke L: Research on the action of metoclopramide in the gastro-intestinal tract , in Schattaver FK (ed): Modern Gastroenterology: Proceedings of VIII International Congress on Gastroenterology, Prague, July 1968 . Stuttgart, Germany, Springer-Verlag, 1969, pp 571-572. 5. Pinder RM, Brogden RN, Sawyer PR: Metoclopramide: A review of its pharmacological properties and clinical use . Drugs 1976;12:81-131.Crossref 6. Bateman DN, Kohn C, Moshiter K, et al: Pharmacokinetics and concentration-effect studies with intravenous metoclopramide . Br J Clin Pharmacol 1978;6:401-407.Crossref 7. Jacoby HI, Brodie DA: Gastro-intestinal action of metoclopramide: An experimental study . Gastroenterology 1967;52:676-684. 8. Brownlee M, Kroopf SS: Metoclopramide for gastroparesis diabeticorum . N Engl J Med 1974;291:1257-1258. 9. Hay AM: Pharmacological analysis of the effects of metoclopramide on the guinea pig isolated stomach . Gastroenterology 1977;72:864-869. 10. Davidson ED, Hersh T, Brinner RA, et al: The effect of metoclopramide on postoperative ileus: A randomized double-blind study . Ann Surg 1979;190:27-30.Crossref 11. Stadaas JO, Aune S: Clinical trial of metoclopramide on postvagotomy gastric stasis . Arch Surg 1972;104:684-686.Crossref 12. Kennedy T: Metoclopramide in vagotomized stomach: I. Man . Postgrad Med J 1973; 49( (suppl 4) ):81-82.Crossref 13. Hancock BD, Bowen-Jones E, Dixon R, et al: The effect of metoclopramide on gastric emptying of solid meals . Gut 1974;15:462-467.Crossref 14. Banke L, Malstrom J, Heltberg J: The influence of metoclopramide amd neostigmine upon early postvagotomy motor disturbances . Scand J Gastroenterol 1971;7:33-37.Crossref 15. Van Eygen M, Heck E, Dhondt F, et al: A double-blind comparison of domperidone and metoclopramide suppositories in the treatment of nausea and vomiting in children . Postgrad Med J 1979;55( (suppl 1) ):36-39.Crossref 16. Agabiti-Rosei E, Alicandri CL, Corea L: Hypertensive crisis in patients with phaeochromocytoma given metoclopramide . Lancet 1977; 1:600.Crossref 17. Cyr J: Literature evaluation of drugs: Metoclopramide (Maxeran-Nordie Biochemicals) . Can Pharmacol J 1977;110:99-101. 18. Christie DL, Ament ME: Gastric acid hypersecretion in children with duodenal ulcer . Gastroenterology 1976;71:242-244.
American Journal of Diseases of Children – American Medical Association
Published: Apr 1, 1982
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