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Energy Metabolism in Human Obesity

Energy Metabolism in Human Obesity ABNORMALLY HIGH fasting levels of plasma free fatty acids (FFA) and decreased responsiveness of this lipid fraction to various lipolytic stimuli in obese humans and animals have now been documented by several investigators.1-5 Whether such alterations in FFA metabolism relate to obesity as cause or effect, however, remains speculative. We have previously reported the failure of the plasma FFA to rise significantly during periods of prolonged fasting in certain patients with longstanding, therapeutically resistant obesity.1 In contrast, a normal FFA response to fasting has been observed in patients whose obesity seems clearly the result of compulsive overeating. In the present investigation, the plasma FFA response to the more potent lipid-mobilizing action of epinephrine is compared in obese subjects and normal weight controls in two separate experiments: an initial study in which plasma FFA and glucose levels were determined before and 30 minutes after epinephrine administration, and a subsequent http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Energy Metabolism in Human Obesity

JAMA , Volume 189 (8) – Aug 24, 1964

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Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1964.03070080022005
Publisher site
See Article on Publisher Site

Abstract

ABNORMALLY HIGH fasting levels of plasma free fatty acids (FFA) and decreased responsiveness of this lipid fraction to various lipolytic stimuli in obese humans and animals have now been documented by several investigators.1-5 Whether such alterations in FFA metabolism relate to obesity as cause or effect, however, remains speculative. We have previously reported the failure of the plasma FFA to rise significantly during periods of prolonged fasting in certain patients with longstanding, therapeutically resistant obesity.1 In contrast, a normal FFA response to fasting has been observed in patients whose obesity seems clearly the result of compulsive overeating. In the present investigation, the plasma FFA response to the more potent lipid-mobilizing action of epinephrine is compared in obese subjects and normal weight controls in two separate experiments: an initial study in which plasma FFA and glucose levels were determined before and 30 minutes after epinephrine administration, and a subsequent

Journal

JAMAAmerican Medical Association

Published: Aug 24, 1964

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