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ENDOCRINE INFLUENCE ON THE RADIOSENSITIVITY OF THE SKIN AND THE THYROID

ENDOCRINE INFLUENCE ON THE RADIOSENSITIVITY OF THE SKIN AND THE THYROID Abstract Endocrine influence on the sensitivity of the human skin to roentgen rays was recognized early in the history of roentgen therapy. The increased radiosensitivity of the skin of patients with hyperthyroidism soon became a matter of concern to the radiotherapeutist. Careful studies of cutaneous sensitivity to roentgen rays, conducted to establish a more definite skin unit dose, brought to light many other conditions, such as the increased radiosensitivity of the skin premenstrually and during pregnancy and changes in radiosensitivity at puberty (Flaskamp1). All of these conditions definitely pointed to the importance of the sex glands as factors determining cutaneous resistance to radiation. In general it can be said that certain organic and constitutional diseases, especially those affecting the vasomotor system or the sympathetic nervous system (MacKee2), influence the radiosensitivity of the skin. It is noteworthy that the same conditions exercise similar effects with respect to References 1. Flaskamp, W.: Ueber Röntgenschäden und Schäden durch radioaktive Substanzen , Berlin, Urban & Schwarzenberg, 1930. 2. MacKee, G. M.: X-Ray and Radium in the Treatment of Diseases of the Skin , Philadelphia, Lea & Febiger, 1940. 3. Ellinger, F.: (a) Die Lichtempfindlichkeit der menschlichen Haut, ihre Bestimmung und Bedeutung für die lichtbiologische Konstitutionsforschung , Strahlentherapie 44:1, 1932 4. (b) The Biologic Fundamentals of Radiation Therapy , translated by R. Gross, New York, Elsevier Publishing Co., 1941. 5. Saidman, J.: La sensitométrie cutanée , Paris, Gaston Doin & Cie, 1930. 6. Ellinger, F.: Untersuchungen über die Hautwirkungen von Röntgenstrahlen am Kaninchen: I. Die Wirkungen einer mittelharten Strahlung und ihre Beeinflussung durch Thyroxin , Strahlentherapie 43:358,1932 7. II. Weitere Untersuchungen über die Wirkung mittelharter Strahlung am Kaninchenohr , Ellinger Strahlentherapie 47:517, 1933 8. III. Die Wirkung einer harten Strahlung und ihre Beeinflussung durch Tonephin , Ellinger Strahlentherapie 47:727, 1933 9. IV. Die Bedeutung der Schilddrüse für den Ablauf der Hautreaktionen bei mittelharter Strahlung , Ellinger Strahlentherapie 48:97, 1933. 10. Ellinger, F.: Lichtbiologische Konstitutionsstudien , Forsch. u. Fortschr. 8:15, 1932 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

ENDOCRINE INFLUENCE ON THE RADIOSENSITIVITY OF THE SKIN AND THE THYROID

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Publisher
American Medical Association
Copyright
Copyright © 1945 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1945.01510210040009
Publisher site
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Abstract

Abstract Endocrine influence on the sensitivity of the human skin to roentgen rays was recognized early in the history of roentgen therapy. The increased radiosensitivity of the skin of patients with hyperthyroidism soon became a matter of concern to the radiotherapeutist. Careful studies of cutaneous sensitivity to roentgen rays, conducted to establish a more definite skin unit dose, brought to light many other conditions, such as the increased radiosensitivity of the skin premenstrually and during pregnancy and changes in radiosensitivity at puberty (Flaskamp1). All of these conditions definitely pointed to the importance of the sex glands as factors determining cutaneous resistance to radiation. In general it can be said that certain organic and constitutional diseases, especially those affecting the vasomotor system or the sympathetic nervous system (MacKee2), influence the radiosensitivity of the skin. It is noteworthy that the same conditions exercise similar effects with respect to References 1. Flaskamp, W.: Ueber Röntgenschäden und Schäden durch radioaktive Substanzen , Berlin, Urban & Schwarzenberg, 1930. 2. MacKee, G. M.: X-Ray and Radium in the Treatment of Diseases of the Skin , Philadelphia, Lea & Febiger, 1940. 3. Ellinger, F.: (a) Die Lichtempfindlichkeit der menschlichen Haut, ihre Bestimmung und Bedeutung für die lichtbiologische Konstitutionsforschung , Strahlentherapie 44:1, 1932 4. (b) The Biologic Fundamentals of Radiation Therapy , translated by R. Gross, New York, Elsevier Publishing Co., 1941. 5. Saidman, J.: La sensitométrie cutanée , Paris, Gaston Doin & Cie, 1930. 6. Ellinger, F.: Untersuchungen über die Hautwirkungen von Röntgenstrahlen am Kaninchen: I. Die Wirkungen einer mittelharten Strahlung und ihre Beeinflussung durch Thyroxin , Strahlentherapie 43:358,1932 7. II. Weitere Untersuchungen über die Wirkung mittelharter Strahlung am Kaninchenohr , Ellinger Strahlentherapie 47:517, 1933 8. III. Die Wirkung einer harten Strahlung und ihre Beeinflussung durch Tonephin , Ellinger Strahlentherapie 47:727, 1933 9. IV. Die Bedeutung der Schilddrüse für den Ablauf der Hautreaktionen bei mittelharter Strahlung , Ellinger Strahlentherapie 48:97, 1933. 10. Ellinger, F.: Lichtbiologische Konstitutionsstudien , Forsch. u. Fortschr. 8:15, 1932

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Mar 1, 1945

References