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ENCEPHALITIS WITH INTRANUCLEAR INCLUSION BODIES: A CLINICOPATHOLOGIC STUDY

ENCEPHALITIS WITH INTRANUCLEAR INCLUSION BODIES: A CLINICOPATHOLOGIC STUDY Abstract The presence of type A intranuclear inclusion bodies in the central nervous system of patients dying of encephalitis is a rare phenomenon. Dawson1 has reported 2 such cases. In a review of the literature in which so-called inclusion bodies have been described he found no previous reports in which the inclusions were clearly distinguished from products of cellular degeneration. He concluded that no distinctive cellular changes characteristic of virus disease have previously been reported in cases of human encephalitis. Recently, Smith, Lennette and Reames2 reported the only case of fatal encephalitis, that of an infant, in which intranuclear inclusion bodies were present and a virus identical with that of herpes simplex was isolated from the brain. Sabin and Wright3 described a case of fatal virus infection in a laboratory worker in whom transverse myelitis and visceral necrosis developed after the bite of a monkey. Sabin4 isolated References 1. Dawson, J. R., Jr.: (a) Cellular Inclusions in Cerebral Lesions of Lethargic Encephalitis , Am. J. Path. 9:7, 1933 2. Cellular Inclusions in Cerebral Lesions of Epidemic Encephalitis: Second Report , Arch. Neurol. & Psychiat. 31:685 ( (April) ) 1934. 3. Smith, M. G.; Lennette, E. H., and Reames, H. R.: Isolation of the Virus of Herpes Simplex and the Demonstration of Intranuclear Inclusions in a Case of Acute Encephalitis , Am. J. Path. 17:55, 1941. 4. Sabin, A. B., and Wright, A. M.: Acute Ascending Myelitis Following a Monkey Bite, with the Isolation of a Virus Capable of Reproducing the Disease , J. Exper. Med. 59:115, 1934. 5. Sabin, A. B.: Studies on the B Virus: I. The Immunological Identity of a Virus Isolated from a Human Case of Ascending Myelitis Associated with Visceral Necrosis , Brit. J. Exper. Path. 15:248, 1934 6. II. Properties of the Virus and Pathogenesis of the Experimental Disease in Rabbits , Sabin Brit. J. Exper. Path. 15:268, 1934 7. III. The Experimental Disease in Macacus Rhesus Monkeys , Sabin Brit. J. Exper. Path. 15:321, 1934. 8. Da Fano, C.: The Histo-Pathology of Epidemic (Lethargic) Encephalitis , Brit. M. J. 1:153, 1921. 9. Meleney, H. E.: Degeneration Granules in Brain Cells in Epidemic Encephalitis , Arch. Neurol. & Psychiat. 5:146 ( (Feb.) ) 1921. 10. Leyaditi, C.: Les ultravirus provocateurs des ectodermoses neurotropes , Ann. Inst. Pasteur 45:673, 1930. 11. Muckenfuss, R. S.: Epidemic Encephalitis , Bull. New York Acad. Med. 17:487, 1941. 12. Foster, H. E., and Cockrill, J. R.: Cerebrospinal Fluid in Encephalitis Lethargica , Am. J. M. Sc. 167:696, 1924. 13. Greenfield, J. G., and Carmichael, E. A.: The Cerebro-Spinal Fluid in Clinical Diagnosis , New York, The Macmillan Company, 1925, p. 170. 14. Fulton, J. F.: Spasticity and the Frontal Lobes: A Review , New England J. Med. 217:1017, 1937. 15. Fulton, J. F., and Kennard, M. A.: A Study of Flaccid and Spastic Paralyses Produced by Lesions of the Cerebral Cortex in Primates , A. Research Nerv. & Ment. Dis., Proc. (1932) 13:158, 1934. 16. Cowdry, E. V.: The Problem of Intranuclear Inclusions in Virus Diseases , Arch. Path. 18:527 ( (Oct.) ) 1934. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

ENCEPHALITIS WITH INTRANUCLEAR INCLUSION BODIES: A CLINICOPATHOLOGIC STUDY

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Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1942.02290030011001
Publisher site
See Article on Publisher Site

Abstract

Abstract The presence of type A intranuclear inclusion bodies in the central nervous system of patients dying of encephalitis is a rare phenomenon. Dawson1 has reported 2 such cases. In a review of the literature in which so-called inclusion bodies have been described he found no previous reports in which the inclusions were clearly distinguished from products of cellular degeneration. He concluded that no distinctive cellular changes characteristic of virus disease have previously been reported in cases of human encephalitis. Recently, Smith, Lennette and Reames2 reported the only case of fatal encephalitis, that of an infant, in which intranuclear inclusion bodies were present and a virus identical with that of herpes simplex was isolated from the brain. Sabin and Wright3 described a case of fatal virus infection in a laboratory worker in whom transverse myelitis and visceral necrosis developed after the bite of a monkey. Sabin4 isolated References 1. Dawson, J. R., Jr.: (a) Cellular Inclusions in Cerebral Lesions of Lethargic Encephalitis , Am. J. Path. 9:7, 1933 2. Cellular Inclusions in Cerebral Lesions of Epidemic Encephalitis: Second Report , Arch. Neurol. & Psychiat. 31:685 ( (April) ) 1934. 3. Smith, M. G.; Lennette, E. H., and Reames, H. R.: Isolation of the Virus of Herpes Simplex and the Demonstration of Intranuclear Inclusions in a Case of Acute Encephalitis , Am. J. Path. 17:55, 1941. 4. Sabin, A. B., and Wright, A. M.: Acute Ascending Myelitis Following a Monkey Bite, with the Isolation of a Virus Capable of Reproducing the Disease , J. Exper. Med. 59:115, 1934. 5. Sabin, A. B.: Studies on the B Virus: I. The Immunological Identity of a Virus Isolated from a Human Case of Ascending Myelitis Associated with Visceral Necrosis , Brit. J. Exper. Path. 15:248, 1934 6. II. Properties of the Virus and Pathogenesis of the Experimental Disease in Rabbits , Sabin Brit. J. Exper. Path. 15:268, 1934 7. III. The Experimental Disease in Macacus Rhesus Monkeys , Sabin Brit. J. Exper. Path. 15:321, 1934. 8. Da Fano, C.: The Histo-Pathology of Epidemic (Lethargic) Encephalitis , Brit. M. J. 1:153, 1921. 9. Meleney, H. E.: Degeneration Granules in Brain Cells in Epidemic Encephalitis , Arch. Neurol. & Psychiat. 5:146 ( (Feb.) ) 1921. 10. Leyaditi, C.: Les ultravirus provocateurs des ectodermoses neurotropes , Ann. Inst. Pasteur 45:673, 1930. 11. Muckenfuss, R. S.: Epidemic Encephalitis , Bull. New York Acad. Med. 17:487, 1941. 12. Foster, H. E., and Cockrill, J. R.: Cerebrospinal Fluid in Encephalitis Lethargica , Am. J. M. Sc. 167:696, 1924. 13. Greenfield, J. G., and Carmichael, E. A.: The Cerebro-Spinal Fluid in Clinical Diagnosis , New York, The Macmillan Company, 1925, p. 170. 14. Fulton, J. F.: Spasticity and the Frontal Lobes: A Review , New England J. Med. 217:1017, 1937. 15. Fulton, J. F., and Kennard, M. A.: A Study of Flaccid and Spastic Paralyses Produced by Lesions of the Cerebral Cortex in Primates , A. Research Nerv. & Ment. Dis., Proc. (1932) 13:158, 1934. 16. Cowdry, E. V.: The Problem of Intranuclear Inclusions in Virus Diseases , Arch. Path. 18:527 ( (Oct.) ) 1934.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Mar 1, 1942

References