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Elevated Threshold for Thyrotropin Suppression in Congenital Hypothyroidism

Elevated Threshold for Thyrotropin Suppression in Congenital Hypothyroidism Abstract • Five infants with congenital hypothyroidism were found to have persistently elevated levels of serum thyrotropin (TSH) for six to 24 months after administration of adequate doses of thyroxine. In these infants, the hypothalamic-pituitary threshold for TSH suppression by thyroxine seems to be unusually high. These observations suggest that serum TSH levels should not be the sole criterion for evaluating adequacy of thyroid hormone replacement during the initial months of therapy for congenital hypothyroidism. (Am J Dis Child 134:19-20, 1980) References 1. Fisher DA: Thyroid function in the fetus , in Fisher DA, Burrow GN (eds): Perinatal Thyroid Physiology and Disease , Kroc Foundation Symposia Series vol 3. New York, Raven Press, 1975, pp 21-32. 2. Sato T, Suzuki Y, Taketani T, et al: Age-related change in pituitary threshold for TSH release during thyroxine replacement therapy for cretinism . J Clin Endocrinol 44:553-559, 1977.Crossref 3. Segal S, Cohen SN, Freeman J, et al: Treatment of congenital hypothyroidism . Pediatrics 62:413-417, 1978. 4. Abassi V, Aldige C: Evaluation of sodium L-thyroxine (T4) requirement in replacement therapy of hypothyroidism . J Pediatr 90:298-301, 1977.Crossref 5. Rezvani I, DiGeorge AM: Reassessment of the daily dose of oral thyroxine for replacement therapy in hypothyroid children . J Pediatr 90:291-297, 1977.Crossref 6. Cotton GE, Gorman CA, Mayberry WE: Suppression of thyrotropin (h-TSH) in serums of patients with myxedema of varying etiology treated with thyroid hormones . N Engl J Med 285:529-533, 1971.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Elevated Threshold for Thyrotropin Suppression in Congenital Hypothyroidism

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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1980.02130130011004
Publisher site
See Article on Publisher Site

Abstract

Abstract • Five infants with congenital hypothyroidism were found to have persistently elevated levels of serum thyrotropin (TSH) for six to 24 months after administration of adequate doses of thyroxine. In these infants, the hypothalamic-pituitary threshold for TSH suppression by thyroxine seems to be unusually high. These observations suggest that serum TSH levels should not be the sole criterion for evaluating adequacy of thyroid hormone replacement during the initial months of therapy for congenital hypothyroidism. (Am J Dis Child 134:19-20, 1980) References 1. Fisher DA: Thyroid function in the fetus , in Fisher DA, Burrow GN (eds): Perinatal Thyroid Physiology and Disease , Kroc Foundation Symposia Series vol 3. New York, Raven Press, 1975, pp 21-32. 2. Sato T, Suzuki Y, Taketani T, et al: Age-related change in pituitary threshold for TSH release during thyroxine replacement therapy for cretinism . J Clin Endocrinol 44:553-559, 1977.Crossref 3. Segal S, Cohen SN, Freeman J, et al: Treatment of congenital hypothyroidism . Pediatrics 62:413-417, 1978. 4. Abassi V, Aldige C: Evaluation of sodium L-thyroxine (T4) requirement in replacement therapy of hypothyroidism . J Pediatr 90:298-301, 1977.Crossref 5. Rezvani I, DiGeorge AM: Reassessment of the daily dose of oral thyroxine for replacement therapy in hypothyroid children . J Pediatr 90:291-297, 1977.Crossref 6. Cotton GE, Gorman CA, Mayberry WE: Suppression of thyrotropin (h-TSH) in serums of patients with myxedema of varying etiology treated with thyroid hormones . N Engl J Med 285:529-533, 1971.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jan 1, 1980

References