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ELEVATED LESIONS OF THE MACULAR AREA: A Histopathologic Study Emphasizing Lesions Similar to Disciform Degeneration of the Macula

ELEVATED LESIONS OF THE MACULAR AREA: A Histopathologic Study Emphasizing Lesions Similar to... Abstract DIFFICULTIES encountered in the differential diagnosis, in the eyes of two patients, of almost identical unilateral elevated macular lesions, one benign, the other malignant, provided the stimulus for this paper. Both eyes were enucleated, with a clinical diagnosis of malignant melanoma of the macula. Because one proved to be a disciform degeneration with an unusual degree of elevation, a study of non-neoplastic lesions of the macula was undertaken with the hope of gaining information which might help to avoid such errors in the future. Permission was obtained from the Armed Forces Institute of Pathology to study sections of 23 eyes coded as disciform degeneration of the macula in the Registry of Ophthalmic Pathology. The differential diagnosis of macular lesions producing elevation is primarily concerned with malignant melanoma and senile disciform degeneration of the macula. Other lesions which occur considerably less frequently include (1) choroidal or subretinal hemorrhage, (2) metastatic carcinoma, References 1. Reese,3 p. 276. 2. Adler, F. H.: Personal communication to the author. 3. References 5 to 12. 4. Pagenstecher and Genth,13 cited by Junius and Kuhnt.15 5. Reese,3 p. 257. 6. Reese,3 p. 250. 7. Verhoeff, F. H., and Grossman, H. P.: Pathogenesis of Disciform Degeneration of the Macula , Arch. Ophth. 18:561-585 ( (Oct.) ) 1937.Crossref 8. Duke-Elder, W. S.: Text-Book of Ophthalmology , Vol. III, St. Louis, C. V. Mosby Company, 1945, p. 2121. 9. Reese, A. B.: Tumors of the Eye , New York, Paul B. Hoeber, Inc., 1951. 10. Bedell, A. J.: The Macula in the Elderly , Am. J. Ophth. 33:1681-1737 ( (Nov.) ) 1950. 11. François, J.: La dégénérescence maculaire par sclérose du réseau choroïdien , Bull. Soc. belg. opht. , No. (72) , pp. 74-81, 1936. 12. Rizzi, C.: Degenerazione maculare senile della retina , Arch. ottal. 43:149-170 ( (April) ) 1936. 13. Sandoz, Y. V.: Beidseitiger histologischer Befund bei senilem Maculopseudotumor, der zu einer neuen Auffassung dieser Altersveränderung führt , von Graefes Arch. Ophth. 140:725-747, 1939.Crossref 14. Mauas, J.: Pseudotumeur de la région maculaire , Bull. et mém. Soc. franç. opht. 52:218-220, 1939. 15. Magitot, A.: Dégénérescence maculaire pseudotumorale (disciforme): Étude anatomique , Ann. ocul. 176:721-728 ( (Oct.) ) 1939. 16. Brown, E. V. L.: Retroretinal Tissue from the Choroid in Kuhnt-Junius Degeneration of the Macula: Anatomic Study , Arch. Ophth. 23:1157-1168 ( (June) ) 1940.Crossref 17. Holm, S.: Macular Proliferation (Pseudotumour) and Closely Related Pictures of Disease (Retinitis Circinata, Coats's Disease, etc.) , Acta ophth. , (Supp. 19) , 1941. 18. Maxwell, E.: Disciform Degeneration of the Macula , Am. J. Ophth. 34:1000-1003 ( (June) ) 1951. 19. Pagenstecher, H., and Genth, G. P.: Atlas der pathologischen Anatomie des Augapfels , Wiesbaden, C. W. Kreidel, 1875. 20. Adler, F. H.: Disciform Degeneration of the Macula (Junius and Kuhnt): Review of the Literature Since the Appearance of Junius and Kuhnt's Paper, 1926 , Arch. Ophth. 10:379-386 ( (Sept.) ) 1933.Crossref 21. Junius, P., and Kuhnt, H.: Die scheibenförmige Entartung der Netzhautmitte , Berlin, S. Karger, 1926. 22. Michel, J.: Über Geschwülste des Uvealtractus , Arch. f. Ophth. 24:131-147, 1878. 23. Behr, C.: Ein weiterer Beitrag zur Anatomie und zur Pathogenese der scheibenförmigen Degeneration am hinteren Augenpol , Ztschr. Augenh. 75:216-237 ( (Oct.) ) 1931. 24. Klien, B. A.: Macular Lesions of Vascular Origin , Am. J. Ophth. 34:1279-1289 ( (Sept.) ) 1951. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Ophthalmology American Medical Association

ELEVATED LESIONS OF THE MACULAR AREA: A Histopathologic Study Emphasizing Lesions Similar to Disciform Degeneration of the Macula

A.M.A. Archives of Ophthalmology , Volume 53 (1) – Jan 1, 1955

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Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-6339
DOI
10.1001/archopht.1955.00930010084008
Publisher site
See Article on Publisher Site

Abstract

Abstract DIFFICULTIES encountered in the differential diagnosis, in the eyes of two patients, of almost identical unilateral elevated macular lesions, one benign, the other malignant, provided the stimulus for this paper. Both eyes were enucleated, with a clinical diagnosis of malignant melanoma of the macula. Because one proved to be a disciform degeneration with an unusual degree of elevation, a study of non-neoplastic lesions of the macula was undertaken with the hope of gaining information which might help to avoid such errors in the future. Permission was obtained from the Armed Forces Institute of Pathology to study sections of 23 eyes coded as disciform degeneration of the macula in the Registry of Ophthalmic Pathology. The differential diagnosis of macular lesions producing elevation is primarily concerned with malignant melanoma and senile disciform degeneration of the macula. Other lesions which occur considerably less frequently include (1) choroidal or subretinal hemorrhage, (2) metastatic carcinoma, References 1. Reese,3 p. 276. 2. Adler, F. H.: Personal communication to the author. 3. References 5 to 12. 4. Pagenstecher and Genth,13 cited by Junius and Kuhnt.15 5. Reese,3 p. 257. 6. Reese,3 p. 250. 7. Verhoeff, F. H., and Grossman, H. P.: Pathogenesis of Disciform Degeneration of the Macula , Arch. Ophth. 18:561-585 ( (Oct.) ) 1937.Crossref 8. Duke-Elder, W. S.: Text-Book of Ophthalmology , Vol. III, St. Louis, C. V. Mosby Company, 1945, p. 2121. 9. Reese, A. B.: Tumors of the Eye , New York, Paul B. Hoeber, Inc., 1951. 10. Bedell, A. J.: The Macula in the Elderly , Am. J. Ophth. 33:1681-1737 ( (Nov.) ) 1950. 11. François, J.: La dégénérescence maculaire par sclérose du réseau choroïdien , Bull. Soc. belg. opht. , No. (72) , pp. 74-81, 1936. 12. Rizzi, C.: Degenerazione maculare senile della retina , Arch. ottal. 43:149-170 ( (April) ) 1936. 13. Sandoz, Y. V.: Beidseitiger histologischer Befund bei senilem Maculopseudotumor, der zu einer neuen Auffassung dieser Altersveränderung führt , von Graefes Arch. Ophth. 140:725-747, 1939.Crossref 14. Mauas, J.: Pseudotumeur de la région maculaire , Bull. et mém. Soc. franç. opht. 52:218-220, 1939. 15. Magitot, A.: Dégénérescence maculaire pseudotumorale (disciforme): Étude anatomique , Ann. ocul. 176:721-728 ( (Oct.) ) 1939. 16. Brown, E. V. L.: Retroretinal Tissue from the Choroid in Kuhnt-Junius Degeneration of the Macula: Anatomic Study , Arch. Ophth. 23:1157-1168 ( (June) ) 1940.Crossref 17. Holm, S.: Macular Proliferation (Pseudotumour) and Closely Related Pictures of Disease (Retinitis Circinata, Coats's Disease, etc.) , Acta ophth. , (Supp. 19) , 1941. 18. Maxwell, E.: Disciform Degeneration of the Macula , Am. J. Ophth. 34:1000-1003 ( (June) ) 1951. 19. Pagenstecher, H., and Genth, G. P.: Atlas der pathologischen Anatomie des Augapfels , Wiesbaden, C. W. Kreidel, 1875. 20. Adler, F. H.: Disciform Degeneration of the Macula (Junius and Kuhnt): Review of the Literature Since the Appearance of Junius and Kuhnt's Paper, 1926 , Arch. Ophth. 10:379-386 ( (Sept.) ) 1933.Crossref 21. Junius, P., and Kuhnt, H.: Die scheibenförmige Entartung der Netzhautmitte , Berlin, S. Karger, 1926. 22. Michel, J.: Über Geschwülste des Uvealtractus , Arch. f. Ophth. 24:131-147, 1878. 23. Behr, C.: Ein weiterer Beitrag zur Anatomie und zur Pathogenese der scheibenförmigen Degeneration am hinteren Augenpol , Ztschr. Augenh. 75:216-237 ( (Oct.) ) 1931. 24. Klien, B. A.: Macular Lesions of Vascular Origin , Am. J. Ophth. 34:1279-1289 ( (Sept.) ) 1951.

Journal

A.M.A. Archives of OphthalmologyAmerican Medical Association

Published: Jan 1, 1955

References

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