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Electron-Irradiated Ox Fascia and Lyophilized Dura Mater: Tissue Reactions

Electron-Irradiated Ox Fascia and Lyophilized Dura Mater: Tissue Reactions Abstract Electron-Beam-Irradiated Ox Fascia When ox fascia was introduced some years ago,1,2 one of the great difficulties was its sterilization. It was impossible to remove it from animals in slaughter houses under aseptic conditions. Also it could not be heated without altering the collagen fibrils. It, therefore, had to be sterilized by chemical sterilization. It was found that an alcohol-acetone-aqueous solution of mercurochrome (Scott's solution) would do this satisfactorily. Laboratory tests showed that this solution would kill the spores of anthrax, tetanus, or gas bacillus in a comparatively short time. However, some quirk in the Federal law prevented the producers (Ethicon) from using this solution. It was then found difficult to find an adequate sterilizing solution which was not also irritant to the tissues, causing an unfavorable reaction when the material was implanted. Finally one was found which was fairly suitable, but even this solution had to be washed out References 1. Koontz, A. R.: Experimental Results in the Use of Dead Fascia Grafts for Hernia Repair , Ann. Surg. 83:523-536 ( (April) ) 1926.Crossref 2. Koontz, A. R.: Dead (Preserved) Fascia Grafts for Hernia Repair: Clinical Results , J.A.M.A. 89:1230-1235 ( (Oct. 8) ) 1927.Crossref 3. Usher, F. C.: Use of Freeze Dried Human Fascia Lata in the Repair of Incisional Hernias , Am. Surgeon 21:364-369 ( (April) ) 1955. 4. Usher, F. C.: Use of Lyophilized Homografts of Dura Mater in the Repair of Inguinal Hernias , Am. Surgeon 23:281-285 ( (March) ) 1957. 5. Usher, F. C.: Personal communication to the authors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Electron-Irradiated Ox Fascia and Lyophilized Dura Mater: Tissue Reactions

Archives of Surgery , Volume 82 (2) – Feb 1, 1961

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Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1961.01300080146014
Publisher site
See Article on Publisher Site

Abstract

Abstract Electron-Beam-Irradiated Ox Fascia When ox fascia was introduced some years ago,1,2 one of the great difficulties was its sterilization. It was impossible to remove it from animals in slaughter houses under aseptic conditions. Also it could not be heated without altering the collagen fibrils. It, therefore, had to be sterilized by chemical sterilization. It was found that an alcohol-acetone-aqueous solution of mercurochrome (Scott's solution) would do this satisfactorily. Laboratory tests showed that this solution would kill the spores of anthrax, tetanus, or gas bacillus in a comparatively short time. However, some quirk in the Federal law prevented the producers (Ethicon) from using this solution. It was then found difficult to find an adequate sterilizing solution which was not also irritant to the tissues, causing an unfavorable reaction when the material was implanted. Finally one was found which was fairly suitable, but even this solution had to be washed out References 1. Koontz, A. R.: Experimental Results in the Use of Dead Fascia Grafts for Hernia Repair , Ann. Surg. 83:523-536 ( (April) ) 1926.Crossref 2. Koontz, A. R.: Dead (Preserved) Fascia Grafts for Hernia Repair: Clinical Results , J.A.M.A. 89:1230-1235 ( (Oct. 8) ) 1927.Crossref 3. Usher, F. C.: Use of Freeze Dried Human Fascia Lata in the Repair of Incisional Hernias , Am. Surgeon 21:364-369 ( (April) ) 1955. 4. Usher, F. C.: Use of Lyophilized Homografts of Dura Mater in the Repair of Inguinal Hernias , Am. Surgeon 23:281-285 ( (March) ) 1957. 5. Usher, F. C.: Personal communication to the authors.

Journal

Archives of SurgeryAmerican Medical Association

Published: Feb 1, 1961

References

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