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Deaton Wr, Bradshaw Hh (1952)
A long-lasting local anesthetic solution use in thoracic surgery.American Surgeon, 18
Tucker Cc (1952)
The control of postoperative pain in ano-rectal surgery.The Journal of the Kansas Medical Society, 53
W. E. Brown , V. M. Wilder (1944)
A Study of Oils Used for Intramuscular Injections: Study of Physical, Chemical, and Biologic FactorsJ. Lab. & Clin. Med., 29
F. C. Yeomans , R. V. Gorsch (1928)
Benacol in Treatment of Pruritus Ani: Preliminary ReportM. Rec., 127
A. Iason, H. Shaftel (1952)
A new approach to the problem of postoperative pain.American journal of surgery, 83 4
M. Kelly (1947)
Failure of oil-soluble anaesthetics to give prolonged analgesia.Lancet, 1 6456
L. G. Beinhauer , G. J. Thomas (1952)
Intravenous Use of Procaine Hydrochloride in Control of PruritusA. M. A. Arch. Dermat. & Syph., 65
D. Duncan, W. Jarvis (1943)
A COMPARISON OP THE ACTIONS ON NERVE FIBERS OF CERTAIN ANESTHETIC MIXTURES AND SUBSTANCES IN OILAnesthesiology, 4
T. E. Smith (1943)
Relief of Pain Following Anorectal SurgerySouth. M. J., 36
Gross Jm, Shaftel He (1952)
The role of efocaine in anorectal anesthesia and analgesia.New York state journal of medicine, 52
F. E. Emery (1943)
Note on Cysts and Abscesses Induced in Rat by Injection of OilsJ. Lab. & Clin. Med., 28
R. H. Freyberg (1942)
Gold Salts in Treatment of Chronic Arthritis: Metabolic and Clinical StudiesProc. Staff Meet., Mayo Clin., 17
L. Beinhauer, G. Thomas, S. Perrin (1952)
Intravenous use of procaine hydrochloride in control of pruritus.A.M.A. archives of dermatology and syphilology, 65 1
F. Ansbro, A. Iason, H. Shaftel, A. Halpern, F. Latteri, B. Bodell (1952)
THE DEVELOPMENT OF EFOCAINE, A NEW APPROACH TO PROLONGED LOCAL ANESTHESIAAnesthesiology, 13
Abstract My interest in the use of procaine to control pruritus has extended over a long period. Recently my colleagues and I1 reported on the use of intravenous procaine hydrochloride and are now studying the effects of orally administered procaine-ascorbic-acid combination. This present report deals with the use of a new local anesthetic solution, Efocaine. This product is a combination of procaine base and butyl p-aminobenzoate, which are insoluble in water, but are soluble in the aqueous miscible nontoxic organic solvents, propylene glycol and polyethylene glycol. This solution is at saturation limits, so that when injected into the tissue the contact with aqueous tissue fluids causes the complete precipitation of the active ingredients. The inert solvents are rapidly absorbed and excreted, leaving a microcrystalline drug repository along the lines of injection. The anesthetic depot is slowly absorbed, its effects continuing for a prolonged period. The mechanism of action References 1. Beinhauer, L. G.; Thomas, G. J., and Perrin, S. R.: Intravenous Use of Procaine Hydrochloride in Control of Pruritus , A. M. A. Arch. Dermat. & Syph. 65:39, 1952. 2. Ansbro, F. P.; Iason, A. H.; Shaftel, H. E.; Halpern, A.; Latteri, F., and Bodell, B.: The Development of Efocaine: A New Approach to Prolonged Local Anesthesia , Anesthesiology 13:306, 1952. 3. Iason, A. H., and Shaftel, H. E.: A New Approach to the Problem of Postoperative Pain , Am. J. Surg. 83:549, 1952. 4. Deaton, W. R., Jr., and Bradshaw, H. H.: A Long-Lasting Local Anesthetic Solution: Use in Thoracic Surgery , Am. Surgeon 18:616, 1952. 5. Tucker, C. C.: The Control of Postoperative Pain in Ano-Rectal Surgery , J. Kansas M. Soc. 53:230, 1952. 6. Gross, J. M., and Shaftel, H. E.: The Role of Efocaine in Anorectal Anesthesia and Analgesia , New York J. Med. 52:1413, 1952. 7. Yeomans, F. C.; Gorsch, R. V., and Mathesheimer, J. L.: Benacol in Treatment of Pruritus Ani: Preliminary Report , M. Rec. 127:19, 1928. 8. Kelly, M.: Failure of Oil-Soluble Anesthetics to Give Prolonged Analgesia , Lancet 1:710, 1947. 9. Duncan, D., and Jarvis, W. H.: A Comparison of the Actions on Nerve Fibers of Certain Anesthetic Mixtures and Substances in Oil , Anesthesiology 4:465, 1943. 10. Brown, W. E.; Wilder, V. M., and Schwartz, P.: A Study of Oils Used for Intramuscular Injections: Study of Physical, Chemical, and Biologic Factors , J. Lab. & Clin. Med. 29:259, 1944. 11. Emery, F. E., and Matthews, C. S.: Note on Cysts and Abscesses Induced in Rat by Injection of Oils , J. Lab. & Clin. Med. 28:1795, 1943. 12. Freyberg, R. H.: Gold Salts in Treatment of Chronic Arthritis: Metabolic and Clinical Studies , Proc. Staff Meet., Mayo Clin. 17:534, 1942. 13. Smith, T. E.: Relief of Pain Following Anorectal Surgery , South. M. J. 36:650, 1943. 14. Weinberg, T.: Personal communication to the author.
A.M.A. Archives of Dermatology & Syphilology – American Medical Association
Published: Aug 1, 1953
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