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EFOCAINE IN CONTROL OF PRURITUS

EFOCAINE IN CONTROL OF PRURITUS Abstract My interest in the use of procaine to control pruritus has extended over a long period. Recently my colleagues and I1 reported on the use of intravenous procaine hydrochloride and are now studying the effects of orally administered procaine-ascorbic-acid combination. This present report deals with the use of a new local anesthetic solution, Efocaine. This product is a combination of procaine base and butyl p-aminobenzoate, which are insoluble in water, but are soluble in the aqueous miscible nontoxic organic solvents, propylene glycol and polyethylene glycol. This solution is at saturation limits, so that when injected into the tissue the contact with aqueous tissue fluids causes the complete precipitation of the active ingredients. The inert solvents are rapidly absorbed and excreted, leaving a microcrystalline drug repository along the lines of injection. The anesthetic depot is slowly absorbed, its effects continuing for a prolonged period. The mechanism of action References 1. Beinhauer, L. G.; Thomas, G. J., and Perrin, S. R.: Intravenous Use of Procaine Hydrochloride in Control of Pruritus , A. M. A. Arch. Dermat. & Syph. 65:39, 1952. 2. Ansbro, F. P.; Iason, A. H.; Shaftel, H. E.; Halpern, A.; Latteri, F., and Bodell, B.: The Development of Efocaine: A New Approach to Prolonged Local Anesthesia , Anesthesiology 13:306, 1952. 3. Iason, A. H., and Shaftel, H. E.: A New Approach to the Problem of Postoperative Pain , Am. J. Surg. 83:549, 1952. 4. Deaton, W. R., Jr., and Bradshaw, H. H.: A Long-Lasting Local Anesthetic Solution: Use in Thoracic Surgery , Am. Surgeon 18:616, 1952. 5. Tucker, C. C.: The Control of Postoperative Pain in Ano-Rectal Surgery , J. Kansas M. Soc. 53:230, 1952. 6. Gross, J. M., and Shaftel, H. E.: The Role of Efocaine in Anorectal Anesthesia and Analgesia , New York J. Med. 52:1413, 1952. 7. Yeomans, F. C.; Gorsch, R. V., and Mathesheimer, J. L.: Benacol in Treatment of Pruritus Ani: Preliminary Report , M. Rec. 127:19, 1928. 8. Kelly, M.: Failure of Oil-Soluble Anesthetics to Give Prolonged Analgesia , Lancet 1:710, 1947. 9. Duncan, D., and Jarvis, W. H.: A Comparison of the Actions on Nerve Fibers of Certain Anesthetic Mixtures and Substances in Oil , Anesthesiology 4:465, 1943. 10. Brown, W. E.; Wilder, V. M., and Schwartz, P.: A Study of Oils Used for Intramuscular Injections: Study of Physical, Chemical, and Biologic Factors , J. Lab. & Clin. Med. 29:259, 1944. 11. Emery, F. E., and Matthews, C. S.: Note on Cysts and Abscesses Induced in Rat by Injection of Oils , J. Lab. & Clin. Med. 28:1795, 1943. 12. Freyberg, R. H.: Gold Salts in Treatment of Chronic Arthritis: Metabolic and Clinical Studies , Proc. Staff Meet., Mayo Clin. 17:534, 1942. 13. Smith, T. E.: Relief of Pain Following Anorectal Surgery , South. M. J. 36:650, 1943. 14. Weinberg, T.: Personal communication to the author. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology & Syphilology American Medical Association

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1953 American Medical Association. All Rights Reserved.
ISSN
0096-5979
DOI
10.1001/archderm.1953.01540080085009
Publisher site
See Article on Publisher Site

Abstract

Abstract My interest in the use of procaine to control pruritus has extended over a long period. Recently my colleagues and I1 reported on the use of intravenous procaine hydrochloride and are now studying the effects of orally administered procaine-ascorbic-acid combination. This present report deals with the use of a new local anesthetic solution, Efocaine. This product is a combination of procaine base and butyl p-aminobenzoate, which are insoluble in water, but are soluble in the aqueous miscible nontoxic organic solvents, propylene glycol and polyethylene glycol. This solution is at saturation limits, so that when injected into the tissue the contact with aqueous tissue fluids causes the complete precipitation of the active ingredients. The inert solvents are rapidly absorbed and excreted, leaving a microcrystalline drug repository along the lines of injection. The anesthetic depot is slowly absorbed, its effects continuing for a prolonged period. The mechanism of action References 1. Beinhauer, L. G.; Thomas, G. J., and Perrin, S. R.: Intravenous Use of Procaine Hydrochloride in Control of Pruritus , A. M. A. Arch. Dermat. & Syph. 65:39, 1952. 2. Ansbro, F. P.; Iason, A. H.; Shaftel, H. E.; Halpern, A.; Latteri, F., and Bodell, B.: The Development of Efocaine: A New Approach to Prolonged Local Anesthesia , Anesthesiology 13:306, 1952. 3. Iason, A. H., and Shaftel, H. E.: A New Approach to the Problem of Postoperative Pain , Am. J. Surg. 83:549, 1952. 4. Deaton, W. R., Jr., and Bradshaw, H. H.: A Long-Lasting Local Anesthetic Solution: Use in Thoracic Surgery , Am. Surgeon 18:616, 1952. 5. Tucker, C. C.: The Control of Postoperative Pain in Ano-Rectal Surgery , J. Kansas M. Soc. 53:230, 1952. 6. Gross, J. M., and Shaftel, H. E.: The Role of Efocaine in Anorectal Anesthesia and Analgesia , New York J. Med. 52:1413, 1952. 7. Yeomans, F. C.; Gorsch, R. V., and Mathesheimer, J. L.: Benacol in Treatment of Pruritus Ani: Preliminary Report , M. Rec. 127:19, 1928. 8. Kelly, M.: Failure of Oil-Soluble Anesthetics to Give Prolonged Analgesia , Lancet 1:710, 1947. 9. Duncan, D., and Jarvis, W. H.: A Comparison of the Actions on Nerve Fibers of Certain Anesthetic Mixtures and Substances in Oil , Anesthesiology 4:465, 1943. 10. Brown, W. E.; Wilder, V. M., and Schwartz, P.: A Study of Oils Used for Intramuscular Injections: Study of Physical, Chemical, and Biologic Factors , J. Lab. & Clin. Med. 29:259, 1944. 11. Emery, F. E., and Matthews, C. S.: Note on Cysts and Abscesses Induced in Rat by Injection of Oils , J. Lab. & Clin. Med. 28:1795, 1943. 12. Freyberg, R. H.: Gold Salts in Treatment of Chronic Arthritis: Metabolic and Clinical Studies , Proc. Staff Meet., Mayo Clin. 17:534, 1942. 13. Smith, T. E.: Relief of Pain Following Anorectal Surgery , South. M. J. 36:650, 1943. 14. Weinberg, T.: Personal communication to the author.

Journal

A.M.A. Archives of Dermatology & SyphilologyAmerican Medical Association

Published: Aug 1, 1953

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