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Efficacy of Ivermectin in the Therapy of Cutaneous Larva Migrans

Efficacy of Ivermectin in the Therapy of Cutaneous Larva Migrans Abstract To the Editor.— Cutaneous larva migrans (creeping eruption) is a chronic serpiginous cutaneous eruption caused by penetration of the skin by infective larvae of animal hookworms (usually Ancylostoma braziliense). Spontaneous migration of larvae usually continues for several weeks and may very rarely persist for up to a year. Recommended therapy is tiabendazole (orally or topically).1 It has recently been reported that oral albendazole shows excellent efficacy.2-4 We report our experience with oral ivermectin, the current drug of choice for treating onchocerciasis.5 Patients and Methods.— Since December 1, 1990, all patients with cutaneous larva migrans have been treated with a single 12-mg oral dose (200 μg/kg) of ivermectin in an open prospective study. Twelve patients have been enrolled (Table). They had returned from the Caribbean, West Africa, Thailand, Burundi, or the Gulf of Mexico. In four patients, the creeping eruption appeared during their stay abroad. In the others, the lag time between return and the onset of References 1. Chaudhry AZ, Longworth DL. Cutaneous manifestations of intestinal helminthic infections . Dermatol Clin. 1989;7:275-290. 2. Jones SK, Reynolds NJ, Oliwiecki S, Harman RRM. Oral albendazole for the treatment of cutaneous larva migrans . Br J Dermatol. 1990;122:99-101.Crossref 3. Orihuela AR, Torres JR. Single dose of albendazole in the treatment of cutaneous larva migrans . Arch Dermatol. 1990;126:398-399.Crossref 4. Williams HC, Monk B. Creeping eruption stopped in its tracks by albendazole . Clin Exp Dermatol. 1989;14:355-356.Crossref 5. Goa KL, McTavish D, Clissold SP. Ivermectin: a review of its antifilarial activity, pharmacokinetic properties and clinical efficacy in onchocerciasis . Drugs . 1991;42:640-658.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Efficacy of Ivermectin in the Therapy of Cutaneous Larva Migrans

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Publisher
American Medical Association
Copyright
Copyright © 1992 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1992.01680170130027
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Cutaneous larva migrans (creeping eruption) is a chronic serpiginous cutaneous eruption caused by penetration of the skin by infective larvae of animal hookworms (usually Ancylostoma braziliense). Spontaneous migration of larvae usually continues for several weeks and may very rarely persist for up to a year. Recommended therapy is tiabendazole (orally or topically).1 It has recently been reported that oral albendazole shows excellent efficacy.2-4 We report our experience with oral ivermectin, the current drug of choice for treating onchocerciasis.5 Patients and Methods.— Since December 1, 1990, all patients with cutaneous larva migrans have been treated with a single 12-mg oral dose (200 μg/kg) of ivermectin in an open prospective study. Twelve patients have been enrolled (Table). They had returned from the Caribbean, West Africa, Thailand, Burundi, or the Gulf of Mexico. In four patients, the creeping eruption appeared during their stay abroad. In the others, the lag time between return and the onset of References 1. Chaudhry AZ, Longworth DL. Cutaneous manifestations of intestinal helminthic infections . Dermatol Clin. 1989;7:275-290. 2. Jones SK, Reynolds NJ, Oliwiecki S, Harman RRM. Oral albendazole for the treatment of cutaneous larva migrans . Br J Dermatol. 1990;122:99-101.Crossref 3. Orihuela AR, Torres JR. Single dose of albendazole in the treatment of cutaneous larva migrans . Arch Dermatol. 1990;126:398-399.Crossref 4. Williams HC, Monk B. Creeping eruption stopped in its tracks by albendazole . Clin Exp Dermatol. 1989;14:355-356.Crossref 5. Goa KL, McTavish D, Clissold SP. Ivermectin: a review of its antifilarial activity, pharmacokinetic properties and clinical efficacy in onchocerciasis . Drugs . 1991;42:640-658.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1992

References