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EFFECTS UPON THE LUNG OF VARYING PERIODS OF TEMPORARY OCCLUSION OF THE PULMONARY ARTERY

EFFECTS UPON THE LUNG OF VARYING PERIODS OF TEMPORARY OCCLUSION OF THE PULMONARY ARTERY Abstract THE EXACT sensitivity of pulmonary tissue to ischemia is not known. The purpose of the present investigation was to determine the sensitivity of the lung to varying periods of ischemia produced by temporary complete occlusion of one pulmonary artery. Temporary occlusion of the pulmonary artery may be indicated in certain circumstances; for example, to control bleeding during partial resection of the lung or following injuries to the lung. The data which will be presented in this paper indicate that the lung is relatively less sensitive to ischemia than are many other tissues, notably the central nervous system and the heart. MATERIALS AND METHODS Monkeys (Macacus rhesus) were used. Ether anesthesia was administered by means of an intratracheal tube. All our observations were made on the left lung. In this way the technical procedures could be standardized. The left lung was exposed through an incision made over the left fifth rib. References 1. Schlaepfer, K.: Ligation of Pulmonary Artery of One Lung With and Without Resection of Phrenic Nerve , Arch. Surg. 9:25-94 ( (July) ) 1924Crossref 2. Effect of Ligation of Pulmonary Artery of One Lung Without and With Resection of Phrenic Nerve , Schlaepfer Arch. Surg. 13:623-629 ( (Nov.) ) 1926.Crossref 3. Penrod, K. E., and Hegnauer, A. H.: Effect of Pentothal Sodium on Blood Gas Transport , Am. J. Physiol. 153:81-86 ( (April) ) 1948. 4. Bloomer, W. E.; Harrison, W.; Lindskog, G. E., and Liebow, A. A.: Respiratory Function and Blood Flow in Bronchial Artery After Ligation of Pulmonary Artery , Am. J. Physiol. 157:317-328 ( (May) ) 1949. 5. Kisch, B.; Goldbloom, A. A., and Zucker, G.: Electrocardiographic Changes After Occlusion of Pulmonary Artery or Aorta , Cardiologia 6:83-94, 1942.Crossref 6. Semisch, C. W., III, and Merves, L.: Electrocardiographic Studies on Artificially Produced Pulmonary Artery Occlusion in Human Beings , Arch. Int. Med. 69:417-429 ( (March) ) 1942.Crossref 7. Brock, R. C.: Experiences in Pulmonary Artery Ligation , Guy's Hosp. Rep. 90:217-229, 1940-1941. 8. Ghoreyeb, A. A., and Karsner, H. T.: A Study of the Relation of Pulmonary and Bronchial Circulation , J. Exper. Med. 18:500-506 ( (Nov.) ) 1913.Crossref 9. Mathes, M. E.; Holman, E., and Reichert, F. L.: Study of Bronchial, Pulmonary, and Lymphatic Circulations of Lung Under Various Pathologic Conditions Experimentally Produced , J. Thoracic Surg. 1:339-362 ( (April) ) 1932. 10. Miller, W. S.: Vascular Supply of Bronchial Tree , Am. Rev. Tuberc. 12:87-94 ( (Oct.) ) 1925. 11. Berry, J. L., and de Burgh Daly, I.: Relation Between Pulmonary and Bronchial Vascular Systems , Proc. Roy. Soc., London, s. B 109:319-336 ( (Dec. 2) ) 1931.Crossref 12. Ghoreyeb, A. A., and Karsner, H. T.: A Study of the Relation of Pulmonary and Bronchial Circulation , J. Exper. Med. 18:500-506 ( (Nov.) ) 1913.Crossref 13. Davis, H. A.: Shock and Allied Forms of Failure of the Circulation , New York, Grune & Stratton, Inc., 1949. 14. Mestci, Z.: Die Unterbindung des Pulmonalishauptastes zur Therapie schwerer Hämoptysen , Zentralbl. Chir. 65:1294-1295 ( (June 4) ) 1938. 15. Armand Ugón, C. V.; de Estable, M. C., and Lockhart, J.: Ligadura de la rama izquierda de la arteria pulmonar por hemoptisis grave , Arch. urug. med. 25:230-236 ( (Aug.) ) 1944. 16. Davis, H. A.: A Method of Surgical Management of the Difficult Patent Ductus Arteriosus: A Preliminary Experimental Study, M. Arts & Sc., to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives Surgery American Medical Association

EFFECTS UPON THE LUNG OF VARYING PERIODS OF TEMPORARY OCCLUSION OF THE PULMONARY ARTERY

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Publisher
American Medical Association
Copyright
Copyright © 1952 American Medical Association. All Rights Reserved.
ISSN
0096-6908
DOI
10.1001/archsurg.1952.01260010480006
Publisher site
See Article on Publisher Site

Abstract

Abstract THE EXACT sensitivity of pulmonary tissue to ischemia is not known. The purpose of the present investigation was to determine the sensitivity of the lung to varying periods of ischemia produced by temporary complete occlusion of one pulmonary artery. Temporary occlusion of the pulmonary artery may be indicated in certain circumstances; for example, to control bleeding during partial resection of the lung or following injuries to the lung. The data which will be presented in this paper indicate that the lung is relatively less sensitive to ischemia than are many other tissues, notably the central nervous system and the heart. MATERIALS AND METHODS Monkeys (Macacus rhesus) were used. Ether anesthesia was administered by means of an intratracheal tube. All our observations were made on the left lung. In this way the technical procedures could be standardized. The left lung was exposed through an incision made over the left fifth rib. References 1. Schlaepfer, K.: Ligation of Pulmonary Artery of One Lung With and Without Resection of Phrenic Nerve , Arch. Surg. 9:25-94 ( (July) ) 1924Crossref 2. Effect of Ligation of Pulmonary Artery of One Lung Without and With Resection of Phrenic Nerve , Schlaepfer Arch. Surg. 13:623-629 ( (Nov.) ) 1926.Crossref 3. Penrod, K. E., and Hegnauer, A. H.: Effect of Pentothal Sodium on Blood Gas Transport , Am. J. Physiol. 153:81-86 ( (April) ) 1948. 4. Bloomer, W. E.; Harrison, W.; Lindskog, G. E., and Liebow, A. A.: Respiratory Function and Blood Flow in Bronchial Artery After Ligation of Pulmonary Artery , Am. J. Physiol. 157:317-328 ( (May) ) 1949. 5. Kisch, B.; Goldbloom, A. A., and Zucker, G.: Electrocardiographic Changes After Occlusion of Pulmonary Artery or Aorta , Cardiologia 6:83-94, 1942.Crossref 6. Semisch, C. W., III, and Merves, L.: Electrocardiographic Studies on Artificially Produced Pulmonary Artery Occlusion in Human Beings , Arch. Int. Med. 69:417-429 ( (March) ) 1942.Crossref 7. Brock, R. C.: Experiences in Pulmonary Artery Ligation , Guy's Hosp. Rep. 90:217-229, 1940-1941. 8. Ghoreyeb, A. A., and Karsner, H. T.: A Study of the Relation of Pulmonary and Bronchial Circulation , J. Exper. Med. 18:500-506 ( (Nov.) ) 1913.Crossref 9. Mathes, M. E.; Holman, E., and Reichert, F. L.: Study of Bronchial, Pulmonary, and Lymphatic Circulations of Lung Under Various Pathologic Conditions Experimentally Produced , J. Thoracic Surg. 1:339-362 ( (April) ) 1932. 10. Miller, W. S.: Vascular Supply of Bronchial Tree , Am. Rev. Tuberc. 12:87-94 ( (Oct.) ) 1925. 11. Berry, J. L., and de Burgh Daly, I.: Relation Between Pulmonary and Bronchial Vascular Systems , Proc. Roy. Soc., London, s. B 109:319-336 ( (Dec. 2) ) 1931.Crossref 12. Ghoreyeb, A. A., and Karsner, H. T.: A Study of the Relation of Pulmonary and Bronchial Circulation , J. Exper. Med. 18:500-506 ( (Nov.) ) 1913.Crossref 13. Davis, H. A.: Shock and Allied Forms of Failure of the Circulation , New York, Grune & Stratton, Inc., 1949. 14. Mestci, Z.: Die Unterbindung des Pulmonalishauptastes zur Therapie schwerer Hämoptysen , Zentralbl. Chir. 65:1294-1295 ( (June 4) ) 1938. 15. Armand Ugón, C. V.; de Estable, M. C., and Lockhart, J.: Ligadura de la rama izquierda de la arteria pulmonar por hemoptisis grave , Arch. urug. med. 25:230-236 ( (Aug.) ) 1944. 16. Davis, H. A.: A Method of Surgical Management of the Difficult Patent Ductus Arteriosus: A Preliminary Experimental Study, M. Arts & Sc., to be published.

Journal

A.M.A. Archives SurgeryAmerican Medical Association

Published: Apr 1, 1952

References

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