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EFFECTS ON THE THROAT AND CONJUNCTIVA OF THE HYGROSCOPIC AGENT USED IN CIGARETS

EFFECTS ON THE THROAT AND CONJUNCTIVA OF THE HYGROSCOPIC AGENT USED IN CIGARETS Abstract Some work has been done on the composition of cigaret smoke and the effect of the various constituents of the smoke on the mucosa of the respiratory tract and on the conjunctival sac. Little investigation has been done on the possible irritative effects of the glycerin or diethylene glycol used as a moistener, or binder, in cigarets on the mucosa exposed to the smoke. Mulinos and Osborne1 found the smoke from cigarets moistened with glycerin more irritating to the conjunctival sac of rabbits than that from those in which diethylene glycol was used, or from those in which no hygroscopic agent was employed. A mechanical smoker was used, in which the smoke was passed through water. Two or three drops of this water was instilled into the conjunctival sac of rabbits. The irritation was determined by the degree of edema produced. Flinn,2 in a clinical investigation on human subjects, obtained References 1. Mulinos, M. G., and Osborne, R. L.: Pharmacology of Inflammation: III. Influence of Hygroscopic Agents on Irritation from Cigarette Smoke , Proc. Soc. Exper. Biol. & Med. 32:241-245 ( (Oct.) ) 1934 2. Irritating Properties of Cigarette Smoke as Influenced by Hygroscopic Agents , New York State J. Med. 35:590-592 ( (June 1) ) 1935. 3. Flinn, F. B.: Some Clinical Observations on the Influence of Certain Hygroscopic Agents in Cigarettes , Laryngoscope 45:149-154 ( (Feb.) ) 1935. 4. Bogen, Emil: The Composition of Cigarets and Cigaret Smoke , J. A. M. A. 93:1110-1114 ( (Oct. 12) ) 1929. 5. Dixon, W. E.: The Physiological Effects of Smoking , Practitioner 118:20-28 ( (Jan.) ) 1927 6. The Tobacco Habit , Brit. M. J. 2:719-725 ( (Oct. 22) ) 1927 7. Lancet 2:881-885 ( (Oct. 22) ) 1927. 8. Rolleston, Humphry: Medical Aspects of Tobacco , Lancet 1:961-965 ( (May 22) ) 1926. 9. Flury, F., and Wirth, W.: Zur Toxikologie der Lösungsmittel (Verschiedene Ester, Aceton, Methylalkohol) , Arch. f. Gewerbepath. u. Gewerbehyg. 5:1-90, 1933. 10. von Oettingen, W. F., and Jirouch, E. A.: Pharmacology of Ethylene Glycol and Some of Its Derivatives in Relation to Their Chemical Constitution and Physical Chemical Properties , J. Pharmacol. & Exper. Therap. 42:355-372, 1931. 11. Brekke, A.: Two Cases of Ethylene Glycol Poisoning , Chem. Abstr. 26:1772, 1932. 12. Hanzlik, P. J., and Hunt, Reid: Toxicity of Ethylene and Propylene Glycol , Indust. & Engin. Chem. 24:836-837 ( (July) ) 1932. 13. Hamilton, Alice: Industrial Toxicology , New York, Harper & Brothers, 1934, p. 201. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

EFFECTS ON THE THROAT AND CONJUNCTIVA OF THE HYGROSCOPIC AGENT USED IN CIGARETS

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Publisher
American Medical Association
Copyright
Copyright © 1937 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1937.00650010083010
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Abstract

Abstract Some work has been done on the composition of cigaret smoke and the effect of the various constituents of the smoke on the mucosa of the respiratory tract and on the conjunctival sac. Little investigation has been done on the possible irritative effects of the glycerin or diethylene glycol used as a moistener, or binder, in cigarets on the mucosa exposed to the smoke. Mulinos and Osborne1 found the smoke from cigarets moistened with glycerin more irritating to the conjunctival sac of rabbits than that from those in which diethylene glycol was used, or from those in which no hygroscopic agent was employed. A mechanical smoker was used, in which the smoke was passed through water. Two or three drops of this water was instilled into the conjunctival sac of rabbits. The irritation was determined by the degree of edema produced. Flinn,2 in a clinical investigation on human subjects, obtained References 1. Mulinos, M. G., and Osborne, R. L.: Pharmacology of Inflammation: III. Influence of Hygroscopic Agents on Irritation from Cigarette Smoke , Proc. Soc. Exper. Biol. & Med. 32:241-245 ( (Oct.) ) 1934 2. Irritating Properties of Cigarette Smoke as Influenced by Hygroscopic Agents , New York State J. Med. 35:590-592 ( (June 1) ) 1935. 3. Flinn, F. B.: Some Clinical Observations on the Influence of Certain Hygroscopic Agents in Cigarettes , Laryngoscope 45:149-154 ( (Feb.) ) 1935. 4. Bogen, Emil: The Composition of Cigarets and Cigaret Smoke , J. A. M. A. 93:1110-1114 ( (Oct. 12) ) 1929. 5. Dixon, W. E.: The Physiological Effects of Smoking , Practitioner 118:20-28 ( (Jan.) ) 1927 6. The Tobacco Habit , Brit. M. J. 2:719-725 ( (Oct. 22) ) 1927 7. Lancet 2:881-885 ( (Oct. 22) ) 1927. 8. Rolleston, Humphry: Medical Aspects of Tobacco , Lancet 1:961-965 ( (May 22) ) 1926. 9. Flury, F., and Wirth, W.: Zur Toxikologie der Lösungsmittel (Verschiedene Ester, Aceton, Methylalkohol) , Arch. f. Gewerbepath. u. Gewerbehyg. 5:1-90, 1933. 10. von Oettingen, W. F., and Jirouch, E. A.: Pharmacology of Ethylene Glycol and Some of Its Derivatives in Relation to Their Chemical Constitution and Physical Chemical Properties , J. Pharmacol. & Exper. Therap. 42:355-372, 1931. 11. Brekke, A.: Two Cases of Ethylene Glycol Poisoning , Chem. Abstr. 26:1772, 1932. 12. Hanzlik, P. J., and Hunt, Reid: Toxicity of Ethylene and Propylene Glycol , Indust. & Engin. Chem. 24:836-837 ( (July) ) 1932. 13. Hamilton, Alice: Industrial Toxicology , New York, Harper & Brothers, 1934, p. 201.

Journal

Archives of Otolaryngology – American Medical Association

Published: Jan 1, 1937

References

  • Pharmacology of Inflammation: III. Influence of Hygroscopic Agents on Irritation from Cigarette Smoke
    Mulinos , M. G., and Osborne, R. L.
  • Irritating Properties of Cigarette Smoke as Influenced by Hygroscopic Agents
  • Some Clinical Observations on the Influence of Certain Hygroscopic Agents in Cigarettes
    Flinn , F. B.
  • The Composition of Cigarets and Cigaret Smoke
    Bogen , Emil
  • The Physiological Effects of Smoking
    Dixon , W. E.
  • The Tobacco Habit
  • Medical Aspects of Tobacco
    Rolleston , Humphry
  • Zur Toxikologie der Lösungsmittel (Verschiedene Ester, Aceton, Methylalkohol)
    Flury , F., and Wirth, W.
  • Pharmacology of Ethylene Glycol and Some of Its Derivatives in Relation to Their Chemical Constitution and Physical Chemical Properties
    von Oettingen , W. F., and Jirouch, E. A.
  • Two Cases of Ethylene Glycol Poisoning
    Brekke , A.
  • Toxicity of Ethylene and Propylene Glycol
    Hanzlik , P. J., and Hunt, Reid
  • Industrial Toxicology
    Hamilton , Alice