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Effects of Two Mineralocorticoids on Ocular Tension

Effects of Two Mineralocorticoids on Ocular Tension Abstract Introduction The effects of corticosteroids on ocular tension have received considerable attention of late, since exogenous steroids have been reported to produce ocular tension increases. Certain topical glucocorticoids, after varying periods of time, have caused ocular tension rises in both glaucomatous and normal individuals.1-3 Minimal ocular tension increases have also been noted in some patients after long-term usage of systemic glucocorticoids.4 The tension elevations after both topical and systemic steroids were secondary to reduced facility of outflow.It is difficult to be certain of the metabolic basis for the ocular tension effects of these steroids. The uncertainty is due to the multiple metabolic effects (eg, anti-inflammatory, glycogenic, catabolic, osteoporotic, and electrolytic) of glucocorticoids. The only adrenal cortical hormones available with predominantly one mode of action (electrolytic) are the mineralocorticoids. Any ocular tension effects of these hormones might elucidate similar effects of other adrenal hormones.This study was undertaken References 1. Becker, B., and Mills, D. W.: Corticosteroids and Intraocular Pressure , Arch Ophthal 70:500, 1963.Crossref 2. Armaly, M. D.: Effect of Corticosteroids on Intraocular Pressure and Fluid Dynamics: I , Arch Ophthal 70:482, 1963.Crossref 3. Armaly, M. D.: Effect of Corticosteroids on Intraocular Pressure and Fluid Dynamics: II , Arch Ophthal 70:492, 1963.Crossref 4. Bernstein, H. N., and Schwartz, B.: Effect of Long-Term Systemic Steroids on Ocular Pressure and Tonographic Values , Arch Ophthal 68:742, 1962.Crossref 5. Ross, E. J., et al: Effect of Intravenous Infusion of dl-Aldosterone Acetate on Sodium and Potassium Excretion in Man , J Clin Endocr 19:289, 1959.Crossref 6. Hechter, O., and Lester, G.: Cell Permeability and Hormonal Action , Recent Progr Hormone Res 16:139, 1960. 7. Duncan, L. E., Jr., et al: Effect of Changes in Body Sodium on Extracellular Fluid Volume and Aldosterone and Sodium Excretion by Normal and Edematous Men , J Clin Invest 35:1299, 1956.Crossref 8. Crabbe, J., et al: Significance of the Secretion of Aldosterone During Dietary Sodium Deprivation in Normal Subjects , J Clin Endocr 18:1159, 1959.Crossref 9. Cole, D. F.: Reduction in Aqueous Humor Formation as Caused by Iodate, Spirolactone, and Polyphloretin Phosphate , Brit J Ophthal 46:291, 1962.Crossref 10. Waitzman, M. B.: Aldosterone and Aqueous Humor Dynamics, Acta Ophthal (Kobenhavn) 41:111, 1963. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Effects of Two Mineralocorticoids on Ocular Tension

Archives of Ophthalmology , Volume 72 (3) – Sep 1, 1964

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Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1964.00970020315004
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction The effects of corticosteroids on ocular tension have received considerable attention of late, since exogenous steroids have been reported to produce ocular tension increases. Certain topical glucocorticoids, after varying periods of time, have caused ocular tension rises in both glaucomatous and normal individuals.1-3 Minimal ocular tension increases have also been noted in some patients after long-term usage of systemic glucocorticoids.4 The tension elevations after both topical and systemic steroids were secondary to reduced facility of outflow.It is difficult to be certain of the metabolic basis for the ocular tension effects of these steroids. The uncertainty is due to the multiple metabolic effects (eg, anti-inflammatory, glycogenic, catabolic, osteoporotic, and electrolytic) of glucocorticoids. The only adrenal cortical hormones available with predominantly one mode of action (electrolytic) are the mineralocorticoids. Any ocular tension effects of these hormones might elucidate similar effects of other adrenal hormones.This study was undertaken References 1. Becker, B., and Mills, D. W.: Corticosteroids and Intraocular Pressure , Arch Ophthal 70:500, 1963.Crossref 2. Armaly, M. D.: Effect of Corticosteroids on Intraocular Pressure and Fluid Dynamics: I , Arch Ophthal 70:482, 1963.Crossref 3. Armaly, M. D.: Effect of Corticosteroids on Intraocular Pressure and Fluid Dynamics: II , Arch Ophthal 70:492, 1963.Crossref 4. Bernstein, H. N., and Schwartz, B.: Effect of Long-Term Systemic Steroids on Ocular Pressure and Tonographic Values , Arch Ophthal 68:742, 1962.Crossref 5. Ross, E. J., et al: Effect of Intravenous Infusion of dl-Aldosterone Acetate on Sodium and Potassium Excretion in Man , J Clin Endocr 19:289, 1959.Crossref 6. Hechter, O., and Lester, G.: Cell Permeability and Hormonal Action , Recent Progr Hormone Res 16:139, 1960. 7. Duncan, L. E., Jr., et al: Effect of Changes in Body Sodium on Extracellular Fluid Volume and Aldosterone and Sodium Excretion by Normal and Edematous Men , J Clin Invest 35:1299, 1956.Crossref 8. Crabbe, J., et al: Significance of the Secretion of Aldosterone During Dietary Sodium Deprivation in Normal Subjects , J Clin Endocr 18:1159, 1959.Crossref 9. Cole, D. F.: Reduction in Aqueous Humor Formation as Caused by Iodate, Spirolactone, and Polyphloretin Phosphate , Brit J Ophthal 46:291, 1962.Crossref 10. Waitzman, M. B.: Aldosterone and Aqueous Humor Dynamics, Acta Ophthal (Kobenhavn) 41:111, 1963.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Sep 1, 1964

References

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