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Effects of Triiodothyronine in Schizophrenic Patients: Correlations of Changes in Basal Metabolism with Urinary Creatine and Cholesterol and Tocopherol Levels in the Blood

Effects of Triiodothyronine in Schizophrenic Patients: Correlations of Changes in Basal... Abstract In a previous paper, the effects of triiodothyronine on the psychiatric status, serum copper, basal metabolism, erythrocyte sedimentation rate, and C-reactive protein in schizophrenic subjects were described.1 Changes in serum cholesterol, plasma tocopherol, and urinary creatine-to-creatinine ratio with respect to the basal metabolic rate (B. M. R.) in chronic schizophrenic subjects treated with triiodothyronine are reported here. At present, there is no reasonable evidence to indicate that metabolic data from these subjects would be different from those obtained from nonschizophrenic subjects. Elevated creatine excretion and B. M. R. and decreased creatinine in the urine, as well as corresponding changes in the serum level of these substances, have been observed in cases of hyperthyroidism.2,4 Both serum cholesterol and tocopherol levels are increased in clinical states of hypothyroidism, and there appears to be an indirect relationship between B. M. R. and blood cholesterol.5,6 References 1. Meyer, B. J.; Meyer, A. C., and Horwitt, M. K.: Effects of Triiodothyronine on Serum Copper and Basal Metabolism in Schizophrenics , Arch. Gen. Psychiat. 1:372, 1959.Crossref 2. Zierler, K. L.; Folk, B. P.; Magladery, J. W., and Lilienthal, J. L., Jr.: On Creatinuria in Man: The Roles of the Renal Tubule and of Muscle Mass , Bull. Johns Hopkins Hosp. 85:370, 1949. 3. Staehelin, A., and Kind, A.: Über den praktisch-diagnostischen Wert der Kreatinstoffwechseluntersuchungen bei den Hyperthyreosen , Praxis 44:351, 1955. 4. Kuhlbäck, B.: Creatine and Creatinine Metabolism in Thyrotoxicosis and Hypothyroidism: A Clinical Study , Acta med. scandinav. ( (Suppl. 331) ) 159:1-70, 1957. 5. Means, J. H.: Thyroid and Its Diseases , Ed. 2, Philadelphia, J. B. Lippincott Company, 1948. 6. Postel, S.: Total Free Tocopherols in the Serum of Patients with Thyroid Disease , J. Clin. Invest. 35:1345, 1956.Crossref 7. Horwitt, M. K.; Harvey, C. C.; Duncan, G. D., and Wilson, W. C.: Effects of Limited Tocopherol Intake in Man with Relationships to Erythrocyte Hemolysis and Lipid Oxidation , Am. J. Clin. Nutrition 4:408, 1956. 8. Bonsnes, R. W., and Taussky, H. H.: On the Colorimetric Determination of Creatinine by the Jaffe Reaction , J. Biol. Chem. 158:581, 1945. 9. Sperry, W. M., and Webb, M.: A Revision of the Schoenheimer-Sperry Method for Cholesterol Determination , J. Biol. Chem. 187:97, 1950. 10. Emmerie, A., and Engle, C.: Colorimetric Determination of dl-α-Tocopherol (Vitamin E) , Nature, London 142:873, 1938.Crossref 11. Quaife, M. L., and Harris, P. L.: Chemical Estimation of Tocopherols in Blood Plasma , J. Biol. Chem. 156:499, 1944. 12. Byrom, F. B.: The Nature of Myxoedema , Clin. Sc. 1:273, 1934. 13. Selenkow, H. A., and Asper, S. P., Jr.: The Effectiveness of Triiodothyronine or Thyroxine Administered Orally in the Treatment of Myxedema , J. Clin. Endocrinol. 15:285, 1955.Crossref 14. Munro, D. S.; Renschler, H., and Wilson, G. M.: Exchangeable Potassium and Sodium in Hyperthyroidism and Hypothyroidism , Metabolism 7:124, 1958. 15. Brøchner-Mortensen, K., and Møller, E.: On Creatinuria and Cholesterolemia in Thyrotoxicosis , Acta med. scandinav. (Supp. 123) , p. 180, 1941. 16. Treusch, J. W.; Kepler, E. J.; Power, M. H., and Haines, S. F.: Creatinuria in Hyperthyroidism and in Essential Hypertension , Am. J.M. Sc. 208:310, 1944.Crossref 17. Peters, J. P., and Man, E. B.: The Interrelations of Serum Lipids in Patients with Thyroid Disease , J. Clin. Invest. 22:715, 1943.Crossref 18. Strisower, E. H.; Gofman, J. W.; Strisower, B., and Delalla, O.: Physiologic Effects of I-Triiodothyronine , J. Clin. Endocrinol. 18:721, 1958.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of General Psychiatry American Medical Association

Effects of Triiodothyronine in Schizophrenic Patients: Correlations of Changes in Basal Metabolism with Urinary Creatine and Cholesterol and Tocopherol Levels in the Blood

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References (19)

Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0375-8532
DOI
10.1001/archpsyc.1960.03590110052006
Publisher site
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Abstract

Abstract In a previous paper, the effects of triiodothyronine on the psychiatric status, serum copper, basal metabolism, erythrocyte sedimentation rate, and C-reactive protein in schizophrenic subjects were described.1 Changes in serum cholesterol, plasma tocopherol, and urinary creatine-to-creatinine ratio with respect to the basal metabolic rate (B. M. R.) in chronic schizophrenic subjects treated with triiodothyronine are reported here. At present, there is no reasonable evidence to indicate that metabolic data from these subjects would be different from those obtained from nonschizophrenic subjects. Elevated creatine excretion and B. M. R. and decreased creatinine in the urine, as well as corresponding changes in the serum level of these substances, have been observed in cases of hyperthyroidism.2,4 Both serum cholesterol and tocopherol levels are increased in clinical states of hypothyroidism, and there appears to be an indirect relationship between B. M. R. and blood cholesterol.5,6 References 1. Meyer, B. J.; Meyer, A. C., and Horwitt, M. K.: Effects of Triiodothyronine on Serum Copper and Basal Metabolism in Schizophrenics , Arch. Gen. Psychiat. 1:372, 1959.Crossref 2. Zierler, K. L.; Folk, B. P.; Magladery, J. W., and Lilienthal, J. L., Jr.: On Creatinuria in Man: The Roles of the Renal Tubule and of Muscle Mass , Bull. Johns Hopkins Hosp. 85:370, 1949. 3. Staehelin, A., and Kind, A.: Über den praktisch-diagnostischen Wert der Kreatinstoffwechseluntersuchungen bei den Hyperthyreosen , Praxis 44:351, 1955. 4. Kuhlbäck, B.: Creatine and Creatinine Metabolism in Thyrotoxicosis and Hypothyroidism: A Clinical Study , Acta med. scandinav. ( (Suppl. 331) ) 159:1-70, 1957. 5. Means, J. H.: Thyroid and Its Diseases , Ed. 2, Philadelphia, J. B. Lippincott Company, 1948. 6. Postel, S.: Total Free Tocopherols in the Serum of Patients with Thyroid Disease , J. Clin. Invest. 35:1345, 1956.Crossref 7. Horwitt, M. K.; Harvey, C. C.; Duncan, G. D., and Wilson, W. C.: Effects of Limited Tocopherol Intake in Man with Relationships to Erythrocyte Hemolysis and Lipid Oxidation , Am. J. Clin. Nutrition 4:408, 1956. 8. Bonsnes, R. W., and Taussky, H. H.: On the Colorimetric Determination of Creatinine by the Jaffe Reaction , J. Biol. Chem. 158:581, 1945. 9. Sperry, W. M., and Webb, M.: A Revision of the Schoenheimer-Sperry Method for Cholesterol Determination , J. Biol. Chem. 187:97, 1950. 10. Emmerie, A., and Engle, C.: Colorimetric Determination of dl-α-Tocopherol (Vitamin E) , Nature, London 142:873, 1938.Crossref 11. Quaife, M. L., and Harris, P. L.: Chemical Estimation of Tocopherols in Blood Plasma , J. Biol. Chem. 156:499, 1944. 12. Byrom, F. B.: The Nature of Myxoedema , Clin. Sc. 1:273, 1934. 13. Selenkow, H. A., and Asper, S. P., Jr.: The Effectiveness of Triiodothyronine or Thyroxine Administered Orally in the Treatment of Myxedema , J. Clin. Endocrinol. 15:285, 1955.Crossref 14. Munro, D. S.; Renschler, H., and Wilson, G. M.: Exchangeable Potassium and Sodium in Hyperthyroidism and Hypothyroidism , Metabolism 7:124, 1958. 15. Brøchner-Mortensen, K., and Møller, E.: On Creatinuria and Cholesterolemia in Thyrotoxicosis , Acta med. scandinav. (Supp. 123) , p. 180, 1941. 16. Treusch, J. W.; Kepler, E. J.; Power, M. H., and Haines, S. F.: Creatinuria in Hyperthyroidism and in Essential Hypertension , Am. J.M. Sc. 208:310, 1944.Crossref 17. Peters, J. P., and Man, E. B.: The Interrelations of Serum Lipids in Patients with Thyroid Disease , J. Clin. Invest. 22:715, 1943.Crossref 18. Strisower, E. H.; Gofman, J. W.; Strisower, B., and Delalla, O.: Physiologic Effects of I-Triiodothyronine , J. Clin. Endocrinol. 18:721, 1958.Crossref

Journal

A.M.A. Archives of General PsychiatryAmerican Medical Association

Published: May 1, 1960

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