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EFFECTS OF RESIN OF PODOPHYLLUM ON NORMAL SKIN, CONDYLOMATA ACUMINATA AND VERRUCAE VULGARES

EFFECTS OF RESIN OF PODOPHYLLUM ON NORMAL SKIN, CONDYLOMATA ACUMINATA AND VERRUCAE VULGARES Abstract PODOPHYLLUM consists of the dried rhizome and roots of Podophyllum peltatum Linneé, the May apple or mandrake, a perennial plant of northern and middle United States.1 The extract and active principle of podophyllum is a complex mixture of resinous substances known as podophyllin, resina podophylli or resin of podophyllum2; it is an amorphous powder varying from light brown to greenish yellow and turning darker when exposed to temperatures exceeding 25 C. or when exposed to light. Resin of podophyllum is soluble in normal solutions of potassium and sodium hydroxide. In alcohol it forms a slightly opalescent and faintly acid solution. Undiluted resin of podophyllum is irritating to mucous membrane, especially that of the eye, where it may produce extensive damage.3 In the past resin of podophyllum was frequently prescribed, as it is an ingredient of the erstwhile popular and official vegetable cathartic pill the formula for which References 1. Blumgarten, A. F.: Text Book of Materia Medica , Pharmacology and Therapeutics , ed. 7, New York, The Macmillan Company, 1937, pp. 220 and 223. 2. Pharmacopoeia of the United States , ed. 11, Easton, Pa., Mack Printing Company, 1936, pp. 294 and 319. 3. Hutchinson, J.: Severe Ulceration of the Corneae Caused by the Dust Given Off by Podophyllin Root Whilst Being Ground , M. Times & Gaz. 2:516, 1872. 4. Chiari, M.: Podophyllinvergiftung , Zentralbl. f. Biochem. Biophysik. 12: 557, 1911-1912 5. La podofillina causa di disturbi oculari , Clin. ocul. 110347, 1910. 6. Viehover, A., and Mack, H.: Biochemistry of May Apple Root (Podophyllum Peltatum) , J. Am. Pharm. A. 27:632, 1938. 7. Pharmacopoeia of the United States , ed. 12, Easton, Pa., Mack Printing Company, 1942, p. lxxxvi. 8. Ivy, A. C.; DeHoog, H., and Gutmann, M.: The Effects of Aloes and Podophyllum (Resin) (Carter's Little Liver Pills) on the Output of Bilirubin and Cholic Acid in Canine Duodenal Drainage Fluid , Quart. Bull. Northwestern Univ. M. School 19:102, 1945. 9. Kittredge, W. E.: Personal communication to the authors. 10. Kaplan, I. W.: Condylomata Acuminata , New Orleans M. & S. J. 94: 338, 1942. 11. Culp, O. S.; Magid, M. A., and Kaplan, I. W.: Podophyllin Treatment of Condylomata Acuminata , J. Urol. 51:655, 1944. 12. Culp, O. S., and Kaplan, I. W.: Condylomata Acuminata: Two Hundred Cases Treated with Podophyllin , Ann. Surg. 120:251, 1944. 13. MacGregor, J. V.: Treatment of Soft Warts with Podophyllin , Brit. M. J. 1:593, 1945. 14. O'Donovan, W. J.: Dermatitis Due to Podophyllin Resin Brit. J. Dermat. 47:13, 1935. 15. Webster, D.: A Case of Poisoning by Contact of the Powder of Resin of Podophyllin , M. Rec. 12:357, 1877. 16. Winterburn, G. A.: Louisville M. News 8:187, 1882. 17. Bentley, R.: Pharm. J. 3:462, 1861 18. Pillsbury, D.; Sulzberger, M., and Livingood, C.: Manual of Dermatology , Military Medical Manuals, Division of Medical Science, Committee on Medicine, National Research Council, Philadelphia, W. B. Saunders Company, 1942, p. 379. 19. King, L. S., and Sullivan, M.: The Similarity of Podophyllin and Colchicine Effects and the Use of These Drugs in the Treatment of Condylomata Acuminata , Science 104:244, 1946. 20. Ludford, R. J.: The Action of Toxic Substances upon the Division of Normal and Malignant Cells in Vitro and in Vivo , Arch. f. exper. Zellforsch. 18:411, 1936 21. Colchicine in the Experimental Chemotherapy of Cancer , J. Nat. Cancer Inst. 6:89, 1945. 22. Lits, F. J.: Recherches sur les reactions cellulaires provoques par la colchicine , Arch. internat. de méd. expér. 11:811, 1936. 23. Dustin, A. P.: Contribution à l'étude de l'action des poisons caryoclasiques sur les tumeurs animales; action du colchicine sure le sarcome greffe; type Crocker, de la souris , Bull. Acad. roy. de méd. de Belgique 14:487, 1934. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

EFFECTS OF RESIN OF PODOPHYLLUM ON NORMAL SKIN, CONDYLOMATA ACUMINATA AND VERRUCAE VULGARES

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Publisher
American Medical Association
Copyright
Copyright © 1947 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1947.01520070033004
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Abstract

Abstract PODOPHYLLUM consists of the dried rhizome and roots of Podophyllum peltatum Linneé, the May apple or mandrake, a perennial plant of northern and middle United States.1 The extract and active principle of podophyllum is a complex mixture of resinous substances known as podophyllin, resina podophylli or resin of podophyllum2; it is an amorphous powder varying from light brown to greenish yellow and turning darker when exposed to temperatures exceeding 25 C. or when exposed to light. Resin of podophyllum is soluble in normal solutions of potassium and sodium hydroxide. In alcohol it forms a slightly opalescent and faintly acid solution. Undiluted resin of podophyllum is irritating to mucous membrane, especially that of the eye, where it may produce extensive damage.3 In the past resin of podophyllum was frequently prescribed, as it is an ingredient of the erstwhile popular and official vegetable cathartic pill the formula for which References 1. Blumgarten, A. F.: Text Book of Materia Medica , Pharmacology and Therapeutics , ed. 7, New York, The Macmillan Company, 1937, pp. 220 and 223. 2. Pharmacopoeia of the United States , ed. 11, Easton, Pa., Mack Printing Company, 1936, pp. 294 and 319. 3. Hutchinson, J.: Severe Ulceration of the Corneae Caused by the Dust Given Off by Podophyllin Root Whilst Being Ground , M. Times & Gaz. 2:516, 1872. 4. Chiari, M.: Podophyllinvergiftung , Zentralbl. f. Biochem. Biophysik. 12: 557, 1911-1912 5. La podofillina causa di disturbi oculari , Clin. ocul. 110347, 1910. 6. Viehover, A., and Mack, H.: Biochemistry of May Apple Root (Podophyllum Peltatum) , J. Am. Pharm. A. 27:632, 1938. 7. Pharmacopoeia of the United States , ed. 12, Easton, Pa., Mack Printing Company, 1942, p. lxxxvi. 8. Ivy, A. C.; DeHoog, H., and Gutmann, M.: The Effects of Aloes and Podophyllum (Resin) (Carter's Little Liver Pills) on the Output of Bilirubin and Cholic Acid in Canine Duodenal Drainage Fluid , Quart. Bull. Northwestern Univ. M. School 19:102, 1945. 9. Kittredge, W. E.: Personal communication to the authors. 10. Kaplan, I. W.: Condylomata Acuminata , New Orleans M. & S. J. 94: 338, 1942. 11. Culp, O. S.; Magid, M. A., and Kaplan, I. W.: Podophyllin Treatment of Condylomata Acuminata , J. Urol. 51:655, 1944. 12. Culp, O. S., and Kaplan, I. W.: Condylomata Acuminata: Two Hundred Cases Treated with Podophyllin , Ann. Surg. 120:251, 1944. 13. MacGregor, J. V.: Treatment of Soft Warts with Podophyllin , Brit. M. J. 1:593, 1945. 14. O'Donovan, W. J.: Dermatitis Due to Podophyllin Resin Brit. J. Dermat. 47:13, 1935. 15. Webster, D.: A Case of Poisoning by Contact of the Powder of Resin of Podophyllin , M. Rec. 12:357, 1877. 16. Winterburn, G. A.: Louisville M. News 8:187, 1882. 17. Bentley, R.: Pharm. J. 3:462, 1861 18. Pillsbury, D.; Sulzberger, M., and Livingood, C.: Manual of Dermatology , Military Medical Manuals, Division of Medical Science, Committee on Medicine, National Research Council, Philadelphia, W. B. Saunders Company, 1942, p. 379. 19. King, L. S., and Sullivan, M.: The Similarity of Podophyllin and Colchicine Effects and the Use of These Drugs in the Treatment of Condylomata Acuminata , Science 104:244, 1946. 20. Ludford, R. J.: The Action of Toxic Substances upon the Division of Normal and Malignant Cells in Vitro and in Vivo , Arch. f. exper. Zellforsch. 18:411, 1936 21. Colchicine in the Experimental Chemotherapy of Cancer , J. Nat. Cancer Inst. 6:89, 1945. 22. Lits, F. J.: Recherches sur les reactions cellulaires provoques par la colchicine , Arch. internat. de méd. expér. 11:811, 1936. 23. Dustin, A. P.: Contribution à l'étude de l'action des poisons caryoclasiques sur les tumeurs animales; action du colchicine sure le sarcome greffe; type Crocker, de la souris , Bull. Acad. roy. de méd. de Belgique 14:487, 1934.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Jul 1, 1947

References