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Effects of Propranolol Therapy on Renal Function and Body Fluid Composition

Effects of Propranolol Therapy on Renal Function and Body Fluid Composition Abstract • Fourteen hypertensive men underwent assessment of renal function and body fluid composition following short-term (three to six weeks), long-term (five to six months), and withdrawal (two weeks) of propranolol hydrochloride mono-therapy for the treatment of hypertension. Results indicate that propranolol had little effect on glomerular filtration rate (<10% decrease); changes that did occur were directly correlated with changes in effective renal plasma flow. Propranolol therapy decreased effective renal plasma flow 14% and renal blood flow 15% during long-term therapy; decreases in renal perfusion persisted following withdrawal of therapy. Propranolol therapy was neither antidiuretic nor antinatriuretic; propranolol had no effect on urine osmolality, free water clearance, sodium clearance, or fractional sodium excretion. Furthermore, propranolol therapy did not expand plasma volume, extracellular fluid volume, or total body water. Finally, propranolol therapy had no effect on the renal handling of potassium or on serum potassium concentration. (Arch Intern Med 1983;143:927-931) References 1. Bauer JH, Brooks CS: The long-term effect of propranolol therapy on renal function. Am J Med 1979;66:405-410.Crossref 2. Weber MA, Drayer JIM: Renal effects of beta-adrenoceptor blockade. Kidney Int 1980;18:686-699.Crossref 3. Wilkinson R: Beta blockers and renal function. Drugs 1982;23:195-206.Crossref 4. Bauer JH, Willis LR, Burt RW, et al: Volume studies: II. Simultaneous determination of plasma volume, red cell mass, extracellular fluid, and total body water before and after volume expansion in dog and man. J Lab Clin Med 1975;86:1009-1017. 5. Walser M, Davidson DG, Orloff J: The renal clearance of alkali-stable inulin. J Clin Invest 1955;34:1520-1523.Crossref 6. Smith HW, Finklestein N, Aliminosa L, et al: The renal clearance of substituted hippuric acid derivatives and other aromatic acids in dog and man. J Clin Invest 1945;24:388-404.Crossref 7. Owen JA, Iggo B, Scandrett PJ, et al: The determination of creatinine in plasma or serum and in urine: A critical examination. Biochem J 1954;58:426-437. 8. Roisters G, Schalekamp MADH, Birkenhager WH, et al: Renin and renal function in benign essential hypertension: Evidence for a renal abnormality , in Berglund G, Hanssen L, Werke L (eds): Pathophysiology and Management of Arterial Hypertension . Möhndal, Sweden, Astra Pharmaceuticals AB, 1975, pp 54-65 9. Nies AS, McNeil JS, Schrier RW: Mechanism of increased sodium reabsorption during propranolol administration. Circulation 1971;44: 596-604.Crossref 10. Schirmeister VH, Decot M, Hallower W, et al: Beta-receptoren und renale Hamodynamik des Meuschen. ArzneimittelForsch 1966;16:847-850. 11. Sullivan JM, Adams DF, Hollenberg NK: Beta-adrenergic blockade in essential hypertension. Cire Res 1976;39:532-536.Crossref 12. Falch DK, Odegaard AE, Norman N: Renal plasma flow and cardiac output during hydralazine and propranolol treatment in essential hypertension. Scand J Clin Lab Invest 1978;38:143-146. 13. O'Connor DT, Preston RA, Sasso EH: Renal perfusion changes during treatment of essential hypertension: Prazosin vs propranolol. J Cardiovasc Pharmacol 1979;l( (suppl) ):38-42.Crossref 14. Warren SE, O'Connor DT, Cohen IM, et al: Renal hemodynamic changes during long-term antihypertensive therapy. Clin Pharm Ther 1981;29:310-317.Crossref 15. O'Connor DT, Preston RA: Urinary kallikrein activity, renal hemodynamics, and electrolyte handling during chronic beta blockade with propranolol in hypertension. Hypertension 1982;4:742-749.Crossref 16. Ibsen H, Sederberg-Olsen P: Changes in glomerular filtration rate during long-term treatment with propranolol in patients with arterial hypertension. Clin Sci 1973;44:129-134. 17. Falch DK, Odegaard AE, Norman N: Decreased renal plasma flow during propranolol treatment in essential hypertension. Acta Med Scand 1979;205:91-95.Crossref 18. Pitts RF: Renal circulation , in Pitts RF (ed): Physiology of the Kidney and Body Fluids , ed 3. Chicago, Year Book Medical Publishers, 1976, pp 167-174. 19. Pederson FB: Abnormal renal hemodynamics during exercise in young patients with mild essential hypertension without treatment and during long-term propranolol therapy. Scand J Clin Lab Invest 1978;38: 567-571.Crossref 20. Sederberg-Olsen P, Ibsen H: Plasma volume and extracellular fluid volume during long-term treatment with propranolol in essential hypertension. Clin Sci 1972;43:165-170. 21. Buhler FR, Laragh JH, Baer L, et al: Propranolol inhibition of renin secretion. JV Engl J Med 1972;287:1209-1214.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Effects of Propranolol Therapy on Renal Function and Body Fluid Composition

Archives of Internal Medicine , Volume 143 (5) – May 1, 1983

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1983.00350050085016
Publisher site
See Article on Publisher Site

Abstract

Abstract • Fourteen hypertensive men underwent assessment of renal function and body fluid composition following short-term (three to six weeks), long-term (five to six months), and withdrawal (two weeks) of propranolol hydrochloride mono-therapy for the treatment of hypertension. Results indicate that propranolol had little effect on glomerular filtration rate (<10% decrease); changes that did occur were directly correlated with changes in effective renal plasma flow. Propranolol therapy decreased effective renal plasma flow 14% and renal blood flow 15% during long-term therapy; decreases in renal perfusion persisted following withdrawal of therapy. Propranolol therapy was neither antidiuretic nor antinatriuretic; propranolol had no effect on urine osmolality, free water clearance, sodium clearance, or fractional sodium excretion. Furthermore, propranolol therapy did not expand plasma volume, extracellular fluid volume, or total body water. Finally, propranolol therapy had no effect on the renal handling of potassium or on serum potassium concentration. (Arch Intern Med 1983;143:927-931) References 1. Bauer JH, Brooks CS: The long-term effect of propranolol therapy on renal function. Am J Med 1979;66:405-410.Crossref 2. Weber MA, Drayer JIM: Renal effects of beta-adrenoceptor blockade. Kidney Int 1980;18:686-699.Crossref 3. Wilkinson R: Beta blockers and renal function. Drugs 1982;23:195-206.Crossref 4. Bauer JH, Willis LR, Burt RW, et al: Volume studies: II. Simultaneous determination of plasma volume, red cell mass, extracellular fluid, and total body water before and after volume expansion in dog and man. J Lab Clin Med 1975;86:1009-1017. 5. Walser M, Davidson DG, Orloff J: The renal clearance of alkali-stable inulin. J Clin Invest 1955;34:1520-1523.Crossref 6. Smith HW, Finklestein N, Aliminosa L, et al: The renal clearance of substituted hippuric acid derivatives and other aromatic acids in dog and man. J Clin Invest 1945;24:388-404.Crossref 7. Owen JA, Iggo B, Scandrett PJ, et al: The determination of creatinine in plasma or serum and in urine: A critical examination. Biochem J 1954;58:426-437. 8. Roisters G, Schalekamp MADH, Birkenhager WH, et al: Renin and renal function in benign essential hypertension: Evidence for a renal abnormality , in Berglund G, Hanssen L, Werke L (eds): Pathophysiology and Management of Arterial Hypertension . Möhndal, Sweden, Astra Pharmaceuticals AB, 1975, pp 54-65 9. Nies AS, McNeil JS, Schrier RW: Mechanism of increased sodium reabsorption during propranolol administration. Circulation 1971;44: 596-604.Crossref 10. Schirmeister VH, Decot M, Hallower W, et al: Beta-receptoren und renale Hamodynamik des Meuschen. ArzneimittelForsch 1966;16:847-850. 11. Sullivan JM, Adams DF, Hollenberg NK: Beta-adrenergic blockade in essential hypertension. Cire Res 1976;39:532-536.Crossref 12. Falch DK, Odegaard AE, Norman N: Renal plasma flow and cardiac output during hydralazine and propranolol treatment in essential hypertension. Scand J Clin Lab Invest 1978;38:143-146. 13. O'Connor DT, Preston RA, Sasso EH: Renal perfusion changes during treatment of essential hypertension: Prazosin vs propranolol. J Cardiovasc Pharmacol 1979;l( (suppl) ):38-42.Crossref 14. Warren SE, O'Connor DT, Cohen IM, et al: Renal hemodynamic changes during long-term antihypertensive therapy. Clin Pharm Ther 1981;29:310-317.Crossref 15. O'Connor DT, Preston RA: Urinary kallikrein activity, renal hemodynamics, and electrolyte handling during chronic beta blockade with propranolol in hypertension. Hypertension 1982;4:742-749.Crossref 16. Ibsen H, Sederberg-Olsen P: Changes in glomerular filtration rate during long-term treatment with propranolol in patients with arterial hypertension. Clin Sci 1973;44:129-134. 17. Falch DK, Odegaard AE, Norman N: Decreased renal plasma flow during propranolol treatment in essential hypertension. Acta Med Scand 1979;205:91-95.Crossref 18. Pitts RF: Renal circulation , in Pitts RF (ed): Physiology of the Kidney and Body Fluids , ed 3. Chicago, Year Book Medical Publishers, 1976, pp 167-174. 19. Pederson FB: Abnormal renal hemodynamics during exercise in young patients with mild essential hypertension without treatment and during long-term propranolol therapy. Scand J Clin Lab Invest 1978;38: 567-571.Crossref 20. Sederberg-Olsen P, Ibsen H: Plasma volume and extracellular fluid volume during long-term treatment with propranolol in essential hypertension. Clin Sci 1972;43:165-170. 21. Buhler FR, Laragh JH, Baer L, et al: Propranolol inhibition of renin secretion. JV Engl J Med 1972;287:1209-1214.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: May 1, 1983

References