Abstract • The effects of oral zinc sulfate (corresponding to 135 mg of zinc daily) alone and in combination with vitamin A (300,000 international units) daily on acne lesions have been compared with those of vitamin A alone and of a placebo. The number of comedones, papules, pustules, and infiltrates were counted at each visit. After four weeks, there was a significant decrease in the number of papules, pustules, and infiltrates in the zinc-treated groups. The effect of zinc plus vitamin A was not better than zinc alone. After 12 weeks of treatment, the mean acne score had decreased from 100% to 15%. The mechanism for the effect of zinc therapy in acne, to our knowledge, is not presently known. (Arch Dermatol 113-31-36, 1977) References 1. Moynahan EF: Acrodermatitis enteropathica: A lethal inherited human zinc deficiency disorder . Lancet 2:399-400, 1974.Crossref 2. Michaëlsson G: Zinc therapy in acrodermatitis enteropathica . Acta Derm Venereol 54:377-381, 1974. 3. Thyresson N: Acrodermatitis enteropathica . Acta Derm Venereol 54:383-385, 1974. 4. Smith JE, Brown ED, Smith JC Jr: The effect of zinc deficiency on the metabolism of retinol-binding protein in the rat . J Lab Clin Med 84:692-697, 1974. 5. Straumfjord JV: Vitamin A: Its effect on acne . Northwest Med 42:219-225, 1943. 6. Sulzberger MB, Wolf J, Witten VH, et al: Dermatology: Diagnosis and Treatment , ed 2. Chicago, Year Book Medical Publishers, Inc, 1961, p 266. 7. Pillsbury DM, Shelley WB, Kligman AM: A Manual of Cutaneous Medicine , Philadelphia, WB Saunders Co., 1961, pp 273-276. 8. Plewig G, Petrozzi JW, Berendes U: Doubleblind study of doxycycline in acne vulgaris . Arch Dermatol 101:435-438, 1970.Crossref 9. Germeraad WF, Vasbinder H, Verbeek AMTA, et al: De behandeling van acne vulgaris met vitamine A . Ned Tijdschr Geneeskd 99:2358-2363, 1955. 10. Anderson JAD, Stokoe JH: Vitamin A in acne vulgaris . Br Med J 2:294-296, 1963.Crossref 11. Kligman AM, Fulton JE, Plewig G: Topical vitamin A acid in acne vulgaris . Arch Dermatol 99:469-476, 1969.Crossref 12. Andersson K-E, Bratt L, Dencker H, et al: Inhibition of tetracycline absorption by zinc . Eur J Clin Pharmacol 10:59-62, 1976.Crossref 13. Reith JF, Engelsma J, Ditmarsch M, et al: Lead and zinc contents of food and diets in the Netherlands . Z Lebensm Unters-Forsch 156:271-278, 1974.Crossref 14. Spencer H: Intake, excretion and retention of zinc in man . Read before the Symposium on Trace Elements and Human Disease, Detroit, July 10 to 12, 1974 . 15. Nordén A, Abdulla M: Zink i kosten . Symposium om zink , Zederfeldt B (ed). Tika, Lund, Sweden, 1974. 16. Sandstead HH: Zinc nutrition in the United States . Am J Clin Nutr 26:1251-1260, 1973. 17. Halsted J, Smith JC, Irwin MJ: A conspectus of research on zinc requirements in man . J Nutr 104:347-378, 1974. 18. Schraer KK, Calloway DH: Zinc balance in pregnant teenagers . Nutr Metab 17:205-212, 1974.Crossref 19. Parisi AF, Valee BL: Zinc metalloenzymes: Characteristics and significance in biology and medicine . Am J Clin Nutr 22:1222-1239, 1969. 20. Calman KC, Muir AV, Milne JA, et al: Survey of the distribution of steroid dehydrogenases in sebaceous glands of human skin . Br J Dermatol 82:567-571, 1970.Crossref 21. Calman KC: Androgens in acne: A new method for the screening of antiandrogens in human skin . Br J Dermatol 82( (suppl 6) ):26-32, 1970.Crossref 22. Chvapil M: New aspects in the biological role of zinc: A stabilizer of macromolecules and biological membranes . Life Sci 13:1041-1049, 1973.Crossref 23. Kazimierczak W, Maśliński C: The effect of zinc ions on selective and nonselective histamine release in vivo . Agents Actions 4:1-6, 1974.Crossref
Archives of Dermatology – American Medical Association
Published: Jan 1, 1977
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